Metolazone supplier | CasNO.17560-51-9

Name
Metolazone
EINECS 241-539-3
CAS No. 17560-51-9
Density 1.4 g/cm³
Solubility 60.3mg/L(25 oC)
Melting Point 252-254°C
Formula C₁₆H₁₆ClN₃O₃S
Boiling Point 613.6 °C at 760 mmHg
Molecular Weight 365.84
Flash Point 324.9 °C
Transport Information
Appearance Crystalline solid
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Metenix;Diulo;6-Quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);2-Methyl-3-(o-tolyl)-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;Metozalone;Mykrox;Normelan;Oldren;SR 720-22;Xuret;Zaroxolyn;
PSA 100.88000
LogP 4.69820

Metolazone Chemical Properties

Molecular Structure:

Molecular Formula: C₁₆H₁₆ClN₃O₃S
Molecular Weight: 365.8345
IUPAC Name: 7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide
Synonyms of Zaroxolyn (CAS NO.17560-51-9): 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone ; 5-25-09-00212 (Beilstein Handbook Reference) ; 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- ; 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- ; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide ; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide ; BRN 0965506 ; Diulo ; EINECS 241-539-3 ; HSDB 3367 ; Metalozone ; Metenix ; Metolazona ; Metolazone ; Metolazonum ; Metolazonum [INN-Latin] ; Microx ; Mykrox ; Oldren ; SR 720-22 ; UNII-TZ7V40X7VX
CAS NO: 17560-51-9
Classification Code: Antihypertensive ; Antihypertensive agents ; Cardiovascular Agents ; Diuretic ; Diuretics ; Drug / Therapeutic Agent ; Human Data ; Natriuretic Agents ; Reproductive Effect
Melting point: 252-254°C
Index of Refraction: 1.629
Molar Refractivity: 92.81 cm³
Molar Volume: 261.2 cm³
Surface Tension: 53.7 dyne/cm
Density: 1.4 g/cm³
Flash Point: 324.9 °C
Enthalpy of Vaporization: 91.06 kJ/mol
Boiling Point: 613.6 °C at 760 mmHg
Vapour Pressure: 5.43E-15 mmHg at 25°C

Metolazone Uses

Zaroxolyn (CAS NO.17560-51-9) is used as a diruetic and an antihypertensive.

Metolazone Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	2mg/kg/2W-I (2mg/kg)	VASCULAR: STRICTIRA; CJAMGES OM VESSE;S	Postgraduate Medical Journal. Vol. 67, Pg. 860, 1991.
mouse	LD50	intraperitoneal	> 1500mg/kg (1500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	United States Patent Document. Vol. #3360518,
mouse	LD50	oral	> 5gm/kg (5000mg/kg)		United States Patent Document. Vol. #3360518,
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982.
rat	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982.
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. 6, Pg. APP-20, 1982.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 261, 1982.
women	TDLo	oral	150ug/kg (0.15mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	British Medical Journal. Vol. 1, Pg. 1381, 1976.

Metolazone Safety Profile

Human systemic effects by ingestion: general anesthesia, convulsions, and muscle contractions. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits Cl⁻, SO_x, and NO_x
RTECS of Zaroxolyn (CAS NO.17560-51-9): VA1700000

Product Name

Metolazone

Metolazone Chemical Properties

Metolazone Uses

Metolazone Toxicity Data With Reference

Metolazone Safety Profile

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