Product Name

  • Name

    Metoprolol

  • EINECS 253-483-7
  • CAS No. 37350-58-6
  • Article Data47
  • CAS DataBase
  • Density 1.033 g/cm3
  • Solubility
  • Melting Point
  • Formula C15H25NO3
  • Boiling Point 398.6 °C at 760 mmHg
  • Molecular Weight 267.37
  • Flash Point 194.9 °C
  • Transport Information
  • Appearance powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 37350-58-6 (Metoprolol)
  • Hazard Symbols
  • Synonyms 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-;1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol;Corvitol;Minax;Presolol;Seroken;Toprol;UNII-GEB06NHM23;
  • PSA 50.72000
  • LogP 2.00410

Metoprolol Chemical Properties


IUPAC Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
Molecular Formula: C15H25NO3
Molecular Weight: 267.36 g/mol
Product Categories: Cardiovascular
EINECS: 253-483-7
Classification Code: Adrenergic Agents; Adrenergic Antagonists; Adrenergic beta-antagonists; Anti-adrenergic [beta-receptor]; Anti-arrhythmia agents; Antihypertensive agents; Autonomic Agents; Cardiovascular Agents; Drug / Therapeutic Agent; Human Data; Neurotransmitter Agents; Peripheral Nervous System Agents; Reproductive Effect; Sympatholytics
Index of Refraction: 1.507
Molar Refractivity: 77.07 cm3
Molar Volume: 258.7 cm3
Surface Tension: 37 dyne/cm
Density: 1.033 g/cm3
Flash Point: 194.9 °C
Enthalpy of Vaporization: 68.47 kJ/mol
Boiling Point: 398.6 °C at 760 mmHg
Vapour Pressure of Metoprolol (CAS NO.37350-58-6): 4.52E-07 mmHg at 25 °C 

Metoprolol Uses

 Metoprolol (CAS NO.37350-58-6) is used as a treatment for high blood pressure drugs, mainly the use of its tartaric acid salt. It also used its hydrochloride. Metoprolol right selective β1 adrenergic receptor blocking effect on the role of β2 receptor is weak, a larger dose of blood vessels and bronchial smooth muscle contraction can, and have a weak role of membrane stabilizing agent, without intrinsic sympathomimetic activity. Can slow down the heart rate, reduce cardiac output and myocardial oxygen consumption, as well as lower blood pressure. Primarily used to treat angina and hypertension. Used to treat high blood pressure and angina pectoris.

Metoprolol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 60mg/kg (60mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 186, 1979.
mouse LD50 intraperitoneal > 200mg/kg (200mg/kg)   Farmaco, Edizione Scientifica. Vol. 41, Pg. 80, 1986.
mouse LD50 intravenous 62mg/kg (62mg/kg)   United States Patent Document. Vol. #4252984,
mouse LD50 oral 1050mg/kg (1050mg/kg)   United States Patent Document. Vol. #4252984,
mouse LD50 subcutaneous > 600mg/kg (600mg/kg)   Collection of Czechoslovak Chemical Communications. Vol. 50, Pg. 2289, 1985.
rat LD50 intravenous 71900ug/kg (71.9mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977.
rat LD50 oral 3470mg/kg (3470mg/kg)   Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 14, Pg. 321, 1977.
women TDLo oral 17mg/kg/17D-I (17mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: EXCITEMENT		 Annals of Internal Medicine. Vol. 108, Pg. 67, 1988.
women TDLo oral 150mg/kg (150mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SLEEP

CARDIAC: CHANGE IN FORCE OF CONTRACTION		 Acta Medica Scandinavica. Vol. 218, Pg. 525, 1985.

Metoprolol Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: cardiac, eye, and behavioral effects. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Metoprolol Specification

  Metoprolol (CAS NO.37350-58-6), its Synonyms are (RS)-Metoprolol ; 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol ; 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)- ; Beatrolol ; Preblok ; Presolol ; Spesicor ; dl-Metoprolol .

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View