Product Name

  • Name

    miporamicin

  • EINECS
  • CAS No. 73684-69-2
  • Article Data2
  • CAS DataBase
  • Density 1.22g/cm3
  • Solubility
  • Melting Point 104°C
  • Formula C37H61 N O13
  • Boiling Point 843.2°C at 760 mmHg
  • Molecular Weight 727.89
  • Flash Point 463.7°C
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 73684-69-2 (miporamicin)
  • Hazard Symbols
  • Synonyms MycinamicinI, 14-hydroxy-; 4,17-Dioxabicyclo[14.1.0]heptadecane, mycinamicin I deriv.;Antibiotic A 11725II; Antibiotic AR 5-2; Miporamicin; Mirosamicin; Mirosamycin;Mycinamicin II; Mycinomycin II
  • PSA 175.21000
  • LogP 1.76370

Synthetic route

mycinamicin II 3'-N-oxide
122825-79-0

mycinamicin II 3'-N-oxide

mycinamicin II
73684-69-2

mycinamicin II

Conditions
ConditionsYield
With triphenylphosphine In dichloromethane at 55℃; for 67h;56%
mycinamicin-IV

mycinamicin-IV

A

C36H59NO11

C36H59NO11

B

mycinamicin-I

mycinamicin-I

C

mycinamicin-III
73684-71-6

mycinamicin-III

D

mycinamicin V
73684-72-7

mycinamicin V

E

mycinamicin II
73684-69-2

mycinamicin II

Conditions
ConditionsYield
With multifunctional biosynthetic P450 monooxygenase; rhodococcus reductase domain; NADPH In aq. buffer at 28℃; for 2h; pH=7.3; Kinetics; Reagent/catalyst; Enzymatic reaction;A 18.5%
B n/a
C n/a
D n/a
E n/a
...Expand
mycinamicin V
73684-72-7

mycinamicin V

mycinamicin II
73684-69-2

mycinamicin II

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 39 percent / MCPBA, disodium hydrogen phosphate / CH2Cl2 / 23 h / 60 °C
2: 56 percent / triphenylphosphine / CH2Cl2 / 67 h / 55 °C
View Scheme

Mirosamicin Chemical Properties

The IUPAC name of Mirosamicin (CAS NO.73684-69-2):
(1R,2S,3R,6E,8S,9S,10S,12R,14E,16R)-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-2-hydroxy-2-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-8,10,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione
Synonyms: Miporamicin;A-11725II ; Antibiotic A-11725II ; Antibiotic AR-5-2 ; AR-5-2 ; Mycinamicin II
CAS: 73684-69-2 
Molecular formula:C37H61NO13
Molecular Structure:

Molecular Weight 727.87914 g/mol
Index of Refraction: 1.545 
Density: 1.22 g/cm3 
Flash Point: 463.7 °C 
Boiling Point: 843.2 °C at 760 mmHg

Mirosamicin Toxicity Data With Reference

The toxicity of  Mirosamicin (CAS NO.73684-69-2):

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 363mg/kg (363mg/kg)   Journal of Antibiotics. Vol. 33, Pg. 364, 1980.
mouse LD50 oral 2gm/kg (2000mg/kg)   British UK Patent Application. Vol. #2020647A,
mouse LD50 subcutaneous 465mg/kg (465mg/kg)   Journal of Antibiotics. Vol. 33, Pg. 364, 1980.

Mirosamicin Safety Profile

The safety information of  Mirosamicin (CAS NO.73684-69-2):
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.

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