The Morphine sulfate, with the CAS registry number 64-31-3,is also known as Astramorph. It belongs to the product categories of Organic matters. This chemical's molecular formula is C34H40N2O10S and molecular weight is 668.75.Its EINECS number is 200-582-8.What's more,Its systematic name is Morphine sulphate.The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Most morphine produced for pharmaceutical use around the world is actually converted into codeine as the concentration of the latter in both raw opium and poppy straw is much lower than that of morphine.Whilst strains of poppies have been engineered to produce much higher yields of the other useful opioid pharmaceutical precursors thebaine and oripavine, no known strain of P. somniferum will produce more codeine than morphine under most or all possible conditions.
Physical properties about Morphine sulfate are:
(1)ACD/LogP: 0.43; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 4; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 2; (6)Flash Point: 241.8 °C; (7)Enthalpy of Vaporization: 77.95 kJ/mol ; (8)Boiling Point: 476.2 °C at 760 mmHg; (9)Vapour Pressure: 7.06E-10 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:[O-]S([O-])(=O)=O.O[C@H]1\C=C/[C@H]5[C@@H]4[NH+](C)CC[C@@]52c3c(O[C@@H]12)c(O)ccc3C4.O[C@H]4\C=C/[C@H]2[C@H]3Cc5c1c(O[C@@H]4[C@]12CC[NH+]3C)c(O)cc5;
(2)Std. InChI:InChI=1S/2C17H19NO3.H2O4S/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t2*10-,11+,13-,16-,17-;/m00./s1;
(3)Std. InChIKey:USAHOPJHPJHUNS-IFCNUISUSA-N.
Safety Information of Morphine sulfate:
The Morphine sulfate is danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .And it is highly flammable.So it need Keep away from sources of ignition. When you use it ,you should wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).After use ,keep container tightly closed.
The toxicity data of Morphine sulfate are as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LDLo | intravenous | 125mg/kg (125mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
dog | LD50 | intravenous | 316mg/kg (316mg/kg) | BEHAVIORAL: SLEEP BEHAVIORAL: ANALGESIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
duck | LD50 | intravenous | 213mg/kg (213mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
frog | LD50 | parenteral | 678mg/kg (678mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
frog | LD50 | subcutaneous | 677mg/kg (677mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948. | |
guinea pig | LD50 | subcutaneous | 391mg/kg (391mg/kg) | Annals of the New York Academy of Sciences. Vol. 51, Pg. 83, 1948. | |
guinea pig | LDLo | intramuscular | 400mg/kg (400mg/kg) | JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914. | |
guinea pig | LDLo | oral | 1gm/kg (1000mg/kg) | JAMA, Journal of the American Medical Association. Vol. 63, Pg. 469, 1914. | |
hamster | LD50 | subcutaneous | 1250mg/kg (1250mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 54, Pg. 339, 1943. | |
man | TDLo | oral | 12mg/kg/4W-I (12mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 397, 1988. |
mouse | LD50 | intracrebral | 5100ug/kg (5.1mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 155, 1963. |
mouse | LD50 | intramuscular | 334mg/kg (334mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971. |
mouse | LD50 | intraperitoneal | 275mg/kg (275mg/kg) | BEHAVIORAL: ANALGESIA | Journal of Medicinal Chemistry. Vol. 10, Pg. 627, 1967. |
mouse | LD50 | intravenous | 156mg/kg (156mg/kg) | BEHAVIORAL: REGIDITY BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 157, Pg. 185, 1967. |
mouse | LD50 | oral | 600mg/kg (600mg/kg) | BEHAVIORAL: ANALGESIA | Journal of Pharmacology and Experimental Therapeutics. Vol. 133, Pg. 400, 1961. |
mouse | LD50 | subcutaneous | 180mg/kg (180mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Australian Veterinary Journal. Vol. 49, Pg. 525, 1973. |
pigeon | LD50 | intravenous | 321mg/kg (321mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 79, Pg. 282, 1949. |
rat | LD50 | intramuscular | 78mg/kg (78mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 190, Pg. 124, 1971. |
rat | LD50 | intraperitoneal | 235mg/kg (235mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 241, 1965. |
rat | LD50 | intravenous | 70mg/kg (70mg/kg) | Toxicology and Applied Pharmacology. Vol. 17, Pg. 250, 1970. | |
rat | LD50 | oral | 461mg/kg (461mg/kg) | British Journal of Pharmacology and Chemotherapy. Vol. 30, Pg. 11, 1967. | |
rat | LD50 | subcutaneous | 108mg/kg (108mg/kg) | ENDOCRINE: OTHER CHANGES | British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 260, 1955. |
women | TDLo | oral | 8mg/kg (8mg/kg) | BEHAVIORAL: ANALGESIA | Lancet. Vol. 1, Pg. 573, 1987. |
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