N-(3-Aminopropyl)morpholine supplier

Name
N-(3-Aminopropyl)morpholine
EINECS 204-590-2
CAS No. 123-00-2
Article Data44
CAS DataBase
Density 0.985 g/cm³
Solubility Soluble
Melting Point -15 °C(lit.)
Formula C₇H₁₆N₂O
Boiling Point 227.8 °C at 760 mmHg
Molecular Weight 144.217
Flash Point 98.9 °C
Transport Information UN 2735 8/PG 2
Appearance Clear liquid
Safety 26-36/37/39-45
Risk Codes 21-34-21/22-36/37
Molecular Structure
Hazard Symbols Xi, C
Synonyms Morpholine,4-(3-aminopropyl)- (6CI,7CI,8CI);1-Amino-3-morpholinopropane;1-Morpholino-3-aminopropane;3-(4-Morpholino)propylamine;3-(4-Morpholinyl)-1-propanamine;3-(4-Morpholinyl)-1-propylamine;3-(4-Morpholinyl)propanamine;3-(4-Morpholinyl)propylamine;3-(Morpholin-4-yl)propylamine;3-(Morpholino)-n-propylamine;3-(N-Morpholino)-1-aminopropane;3-Amino-1-(morpholino)propane;3-Morpholinopropanamine;3-Morpholinopropylamine;4-(3-Aminopropyl)morpholine;4-(g-Aminopropyl)morpholine;4-Morpholinepropanamine;NSC 1081;[3-(4-Morpholinyl)propan-1-yl]amine;[3-(Morpholino)propan-1-yl]amine;g-Morpholinopropylamine;
PSA 38.49000
LogP 0.30560

Synthetic route

: 106018-95-5
2-Trimethylsilanyl-ethanesulfonic acid (3-morpholin-4-yl-propyl)-amide

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 40h;	90%

: 110-91-8
morpholine

Argopore Wang resin-bound 3-amino-1-propanol: Argopore Wang resin-bound 3-amino-1-propanol

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
Stage #1: Argopore Wang resin-bound 3-amino-1-propanol With 1H-imidazole; iodine; triphenylphosphine In N,N-dimethyl-formamide for 16h; Stage #2: morpholine In N,N-dimethyl-formamide at 50℃; for 6h; Stage #3: With trifluoroacetic acid In dichloromethane for 1h;	86%

: 6820-95-7
2-(3-morpholinylpropyl)-1H-isoindole-1,3(2H)-dione

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 24h; Reflux;	86%
With hydrazine hydrate In ethanol at 20℃; Reflux;	85%
With hydrazine hydrate In ethanol Reflux;
With hydrazine hydrate In ethanol for 0.75h; Reflux;
With hydrazine hydrate In ethanol Reflux;

: 4542-47-6
3-Morpholin-4-yl-propionitrile

A: 110-91-8
morpholine

B: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With sodium tetrahydroborate; hydrogen; nickel dichloride In tert-butyl alcohol at 70℃; under 760.051 Torr; for 8h;	A 22% B 59%

: 110-91-8
morpholine

: 42251-84-3
N-(3-chloropropyl)phthalimide

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With xylene Erhitzen des Reaktionsprodukts mit konz. wss. HCl;

: 110-91-8
morpholine

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
Erhitzen des Reaktionsprodukts mit wss. HCl;

: 23159-07-1
3-(1-pyrrolidinyl)propylamine

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With diazene In ethanol for 3h;

: 110-91-8
morpholine

: 6276-54-6
3-chloropropylamine hydrochloride

: 123-00-2
4-(3-Aminopropyl)morpholine

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile at 30℃; for 8h;

: 123-00-2
4-(3-Aminopropyl)morpholine

: 63875-01-4
2-methyl-pyridine-4-carbaldehyde

: 2-methylpyridine-4-carboxaldehyde [3-(4-morpholinyl)propyl]imine

Conditions

Conditions	Yield
With magnesium sulfate	100%
With magnesium sulfate In toluene for 18h;
With magnesium sulfate

: 123-00-2
4-(3-Aminopropyl)morpholine

: 938455-56-2
C17H17F3O3

: 74124-79-1
di(succinimido) carbonate

: C25H31F3N2O5

Conditions

Conditions	Yield
Stage #1: C17H17F3O3; di(succinimido) carbonate With triethylamine In acetonitrile at 20℃; for 1h; Stage #2: 4-(3-Aminopropyl)morpholine In acetonitrile at 20℃; for 0.25h; Further stages.;	100%

...Expand

: 123-00-2
4-(3-Aminopropyl)morpholine

: 314034-08-7
5-methyl 2-(2-chloroethoxy)methyl-4-(3-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

: 314034-14-5
3-methyl-6-(2-chloroethoxy)methyl-4-(3-chlorophenyl)-2-methyl-5-(3-(N-morpholino)propylcarbamoyl)-1,4-dihydropyridine-3-carboxylate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h;	100%
In dichloromethane; ethyl acetate

: 123-00-2
4-(3-Aminopropyl)morpholine

: 98-61-3
4-iodobenzenesulfonyl chloride

: 403793-23-7
N-(3-Morpholinopropyl)-4-iodobenzenesulphonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 16588-16-2
ethyl 4-chloro-3-nitrobenzoate

: 310451-70-8
C16H23N3O5

Conditions

Conditions	Yield
With triethylamine In ethanol at 60℃; for 12h;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 911299-74-6
3-chloro-6,7,8,9-tetrahydronaphto[2,3-e][1,2,4]triazine 1-oxide

: N-[3-(4-morpholinyl)propyl]-6,7,8,9-tetrahydronaphto[2,3-e][1,2,4]triazin-3-amine 1-oxide

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 8h; Reflux;	100%
In 1,2-dimethoxyethane for 0.5h; Heating / reflux;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 52313-46-9
ethyl 2-acetyl-4-oxo-4-phenylbutanoate

: ethyl 2-methyl-1-(3-morpholinopropyl)-5-phenyl-1H-pyrrole-3-carboxylate

Conditions

Conditions	Yield
With 3-hydroxy-4-methylbenzenesulfonic acid In ethanol for 16h; Inert atmosphere; Reflux;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carboxylic acid

: N-(3-morpholinopropyl) 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carboxamide

Conditions

Conditions	Yield
Stage #1: 1-(3,4-dichlorophenyl)-1H-1,2,3-triazole-4-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 2h; Reflux; Stage #2: 4-(3-Aminopropyl)morpholine In tetrahydrofuran at 20℃;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 5231-87-8
3,4-diethoxy-3-cyclobuten-1,2-dione

: 3-ethoxy-4-((3-morpholinopropyl)amino)cyclobut-3-ene-1,2-dione

Conditions

Conditions	Yield
In tetrahydrofuran at -78 - 20℃;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 95-92-1
oxalic acid diethyl ester

: 25148-90-7
N,N'-bis(3-dimethylaminopropyl)oxalamide

Conditions

Conditions	Yield
In ethanol Inert atmosphere; Flow reactor;	100%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 6-bromo-2-(3-morpholinopropyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

Conditions

Conditions	Yield
In ethanol at 90℃; for 12h;	99%
In ethanol at 60℃; for 6h;	87%
In ethanol Reflux;	78.4%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 78287-30-6
(S)-11-cyclohexyl-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

: C33H42N4O5

Conditions

Conditions	Yield
at 60℃; Inert atmosphere;	99%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 2,4-bis(3-formylphenyl)quinoline

: 2,4-bis{3-[(3-morpholinopropyl)iminomethyl]phenyl}quinoline

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	99%

: N-[(E)-dimethylaminomethylideneamino]acetamide

: 123-00-2
4-(3-Aminopropyl)morpholine

: 4-(3-N-morpholine-propyl)-3-methyl-1,2,4-triazole

Conditions

Conditions	Yield
With acetic acid microwave irradiation;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 54448-50-9
3-Chloro-7-methylbenzo-1,2,4-triazine 1-Oxide

: 763131-85-7
7-methyl-N-[3-(4-morpholinyl)propyl]-1,2,4-benzotriazin-3-amine 1-oxide

Conditions

Conditions	Yield
In methanol; 1,2-dimethoxyethane	98%
In 1,2-dimethoxyethane for 8h; Heating / reflux;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 911299-29-1
3-chloro-7-methyl-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1-oxide

: 7-methyl-N-[3-(4-morpholinyl)propyl]-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazin-3-amine 1-oxide

Conditions

Conditions	Yield
With triethylamine In 1,2-dimethoxyethane for 8h; Reflux;	98%
With triethylamine In 1,2-dimethoxyethane for 8h; Heating / reflux;	98%

: 910105-60-1
3-chloro-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazin-3-amine 1-oxide

: 123-00-2
4-(3-Aminopropyl)morpholine

: N-[3-(4-morpholinyl)propyl]-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazin-3-amine 1-oxide

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 8h; Reflux;	98%
In 1,2-dimethoxyethane for 3h; Reflux;	98%
In 1,2-dimethoxyethane for 3h; Heating / reflux;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 57-11-4
stearic acid

: 55852-13-6
N-(3-morpholinopropyl) stearamide

Conditions

Conditions	Yield
With nano sulfated-TiO2 at 115℃; under 760.051 Torr; for 1h; Neat (no solvent);	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 3289-75-6
2-chloro-N-(4-chlorophenyl)acetamide

: N-(4-chlorophenyl)-2-((3-morpholinopropyl)amino)acetamide

Conditions

Conditions	Yield
With triethylamine In acetonitrile Reflux;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 2,4-bis(3-formylphenyl)quinazoline

: 2,4-bis{3-[(3-morpholinopropyl)iminomethyl]phenyl}quinazoline

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 2,4-bis(4-formylphenyl)quinoline

: 2,4-bis{4-[(3-morpholinopropyl)iminomethyl]phenyl}quinoline

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 2-ethoxycarbonyl-3-(p-methoxyphenylamino)quinoxaline

: 3-((4-methoxyphenyl)amino)-N-(3-morpholinopropyl)quinoxaline-2-carboxamide

Conditions

Conditions	Yield
In ethanol at 80℃;	98%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 872-85-5
pyridine-4-carbaldehyde

: (3-Morpholin-4-yl-propyl)-[1-pyridin-4-yl-meth-(E)-ylidene]-amine

Conditions

Conditions	Yield
With magnesium sulfate In toluene for 18h;	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 872-85-5
pyridine-4-carbaldehyde

: 165806-86-0
pyridine-4-carboxaldehyde [4-morpholinylprop-3-yl]imine

Conditions

Conditions	Yield
With magnesium sulfate In toluene for 18h;	97%
With magnesium sulfate In toluene for 18h;	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 221461-77-4
1-<(carbonylazido)-methyl>-4-phenyl-1H-1,2,3-triazole

: N-(3-morpholin-4-yl-propyl)-2-(4-phenyl-[1,2,3]triazol-1-yl)-acetamide

Conditions

Conditions	Yield
In benzene for 6h; Heating;	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 863973-47-1
3-chloro-6-ethoxy-1,2,4-benzotriazine 1-oxide

: 6-ethoxy-N-[3-(4-morpholinyl)propyl]-1,2,4-benzotriazin-3-amine 1-oxide

Conditions

Conditions	Yield
In 1,2-dimethoxyethane for 8h; Heating;	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 224789-27-9
4-propoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

: 3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]triazin-2-yl)-N-(3-morpholin-4-yl-propyl)-4-propoxy-benzenesulfonamide

Conditions

Conditions	Yield
	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 13544-44-0
2,4-dichloro-5-iodopyrimidine

: (2-chloro-5-iodopyrimidine-4-yl)-(3-morpholin-4-yl-propyl)-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at -35 - 20℃; for 72h;	97%
With N-ethyl-N,N-diisopropylamine In acetonitrile at -35 - 20℃; for 73h;	97%
With N-ethyl-N,N-diisopropylamine In acetonitrile at -35 - 20℃; for 73h;	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 3-chloroindeno[1,2-c]isochromene-5,11-dione

: 3-chloro-5,6-dihydro-6-(3-morpholinopropyl)-5,11-dioxo-11H-indeno[1,2-c]isoquinoline

Conditions

Conditions	Yield
In chloroform for 22h; Reflux;	97%

: 123-00-2
4-(3-Aminopropyl)morpholine

: 17669-01-1, 56190-51-3, 15853-98-2
(+)-usnic acid

: (2R,4E)-10-acetyl-11,13-dihydroxy-2,12-dimethyl-4-(1-{[2-(morpholin-4-yl)propyl]amino}ethylidene)-8-oxatricyclo[7.4.0.02,7]trideca-1(9),6,10,12-tetraene-3,5-dione

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	97%

N-(3-Aminopropyl)morpholine Chemical Properties

IUPAC Name: 3-Morpholin-4-ylpropan-1-amine
Synonyms: 3-(Morpholin-4-yl)propan-1-amine ; 4-(Gamma.-Aminopropyl)morpholine ; 4-Morpholinepropanamine ; Morpholine, 4- (3-aminopropyl)-
Molecular Structure of 4-Aminopropylmorpholine (CAS NO.123-00-2) :
Molecular Formula of 4-Aminopropylmorpholine (CAS NO.123-00-2) : C₇H₁₆N₂O
Molecular Weight of 4-Aminopropylmorpholine (CAS NO.123-00-2) : 144.21
CAS NO: 123-00-2
EINECS : 204-590-2
Index of Refraction: 1.473
Surface Tension: 35.5 dyne/cm
Density: 0.985 g/cm³
Flash Point: 98.9 °C
Enthalpy of Vaporization: 46.44 kJ/mol
Boiling Point: 227.8 °C at 760 mmHg
Vapour Pressure: 0.0761 mmHg at 25°C
Melting point: -15 ºC
Water solubility: soluble
Appearance:Clear liquid

N-(3-Aminopropyl)morpholine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	1230uL/kg (1.23mL/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	oral	3560mg/kg (3560mg/kg)		Union Carbide Data Sheet. Vol. 3/25/1970,

N-(3-Aminopropyl)morpholine Consensus Reports

Reported in EPA TSCA Inventory.

N-(3-Aminopropyl)morpholine Safety Profile

A corrosive material. Moderately toxic by several routes. A severe skin and eye irritant. Combustible. Can react with oxidizing materials. To fight fire, use alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NO_x.
Hazard CodesC,Xi
Risk Statements 34-21/22-36/37
R20/21:Harmful by inhalation and in contact with skin.
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system.
Safety Statements 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2735 8/PG 2
WGK Germany 2
RTECS QD7700000
F 10-34
HazardClass 8
PackingGroup II

N-(3-Aminopropyl)morpholine Specification

1.General Description: A colorless liquid with a faint, fishlike odor. Burns, but requires some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.
2.Air & Water Reactions :Soluble in water.
3.Reactivity Profile :N-(3-Aminopropyl)morpholine behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
4.Health Hazard :TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
5.Fire Hazard: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Product Name

N-(3-Aminopropyl)morpholine

Synthetic route

N-(3-Aminopropyl)morpholine Chemical Properties

N-(3-Aminopropyl)morpholine Toxicity Data With Reference

N-(3-Aminopropyl)morpholine Consensus Reports

N-(3-Aminopropyl)morpholine Safety Profile

N-(3-Aminopropyl)morpholine Specification

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