N-(4-Aminobenzoyl)-beta-alanine supplier

Name
N-(4-Aminobenzoyl)-beta-alanine
EINECS 616-017-7
CAS No. 7377-08-4
Article Data7
CAS DataBase
Density 1.303 g/cm³
Solubility
Melting Point 152-154 °C(lit.)
Formula C₁₀H₁₂N₂O₃
Boiling Point 519.4 °C at 760 mmHg
Molecular Weight 208.217
Flash Point 267.9 °C
Transport Information
Appearance white to light orange-brown crystalline powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms b-Alanine, N-(p-aminobenzoyl)-(6CI,7CI,8CI);3-(4-Aminobenzoylamino)propionic acid;3-[(4-Aminobenzoyl)amino]propanoic acid;p-Amino-N-benzoyl-b-alanine;
PSA 92.42000
LogP 1.44540

Synthetic route

: 59642-21-6
N-(4-nitrobenzoyl)-beta-alanine

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

Conditions

Conditions	Yield
With 1% Pd/C; hydrogen In methanol at 20℃;	98%
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; under 750.075 Torr; for 3h; Inert atmosphere;	89%
With palladium on activated carbon; hydrogen In methanol at 20℃; under 750.075 Torr; for 3h;	75%

: 122-04-3
4-nitro-benzoyl chloride

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH solution 2: zinc; acid View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / 2.5 h / 0 - 20 °C 2: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C / 750.08 Torr / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 3 h / 5 °C 2: hydrogen / water / 20 °C / 760.05 Torr 3: hydrogenchloride / water / 0.17 h / pH 1 - 2 View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / 0.5 h / 0 °C 2: palladium on activated carbon; hydrogen / methanol / 3 h / 20 °C / 750.08 Torr View Scheme

: Na(1+)*C10H9N2O5(1-)

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / water / 20 °C / 760.05 Torr 2: hydrogenchloride / water / 0.17 h / pH 1 - 2 View Scheme

: Na(1+)*C10H11N2O3(1-)

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

Conditions

Conditions	Yield
With hydrogenchloride In water for 0.166667h; pH=1 - 2;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 108-95-2
phenol

: (E)-3-(4-((4-hydroxyphenyl)diazenyl)benzamido)propanoic acid

Conditions

Conditions	Yield
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Stage #2: phenol With sodium carbonate; sodium hydroxide In water at 0℃; pH=8;	97%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 69-72-7
salicylic acid

: balsalazide

Conditions

Conditions	Yield
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: salicylic acid With sodium carbonate; sodium hydroxide In water at 0 - 5℃; for 1h;	95%
Stage #1: N-(4-aminobenzoyl)-B-alanine With methanesulfonic acid; sodium nitrite In water at 10 - 12℃; for 0.5h; Stage #2: salicylic acid With sodium hydroxide; sodium carbonate In water at 7 - 12℃; for 3h; Stage #3: With hydrogenchloride; water at 60 - 65℃; for 3h; pH=4.0 - 4.5; Product distribution / selectivity;	90%
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Stage #2: salicylic acid With sodium carbonate; sodium hydroxide In water at 0℃; pH=8;	85%
Stage #1: N-(4-aminobenzoyl)-B-alanine With sodium nitrite In water at -5 - 0℃; for 1.5h; Stage #2: salicylic acid With sodium carbonate; sodium hydroxide In water at -5 - 0℃; for 3h; pH=7.5 - 8.5;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 64-17-5
ethanol

: C12H16N2O3*ClH

Conditions

Conditions	Yield
With thionyl chloride at 0℃; for 5h; Inert atmosphere; Reflux;	93%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 99-96-7
4-hydroxy-benzoic acid

: 3-[4-(4-hydroxy-phenyl-azo)-benzoyl-amino]propionic acid

Conditions

Conditions	Yield
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride In water at 20 - 25℃; Stage #2: With sodium nitrite In water at -2 - 2℃; Stage #3: 4-hydroxy-benzoic acid Further stages;	91%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 108-24-7
acetic anhydride

: 212198-64-6
3-(4-acetylamino-benzoylamino)propionic acid

Conditions

Conditions	Yield
With acetic acid In water at 30 - 45℃;	90%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 884-12-8
β-(N,N-diethylamino)propiophenone hydrochloride

: 3-[4-(3-oxo-3-phenylpropylamino)benzamido]-propanoic acid

Conditions

Conditions	Yield
In water Heating;	87%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 14003-96-4
8-formyl-4-methyl-7-hydroxycoumarin

: 7-hydroxy-4-methyl-8-(4'-(N-carboxyethylformamido)phenylimino)methyl-2H-1-benzopyran-2-one

Conditions

Conditions	Yield
In ethanol Reflux;	85.1%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

A: 773838-08-7
3-(4-hydroxybenzamido)propanoic acid

B: 4-((2-carboxyethyl)carbamoyl)benzenediazonium chloride

Conditions

Conditions	Yield
With hydrogenchloride; nitric acid; sodium nitrite In water at 20℃; for 1h; Reagent/catalyst;	A 7% B 84%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

A: 773838-08-7
3-(4-hydroxybenzamido)propanoic acid

B: 4-((2-carboxyethyl)carbamoyl)benzenediazonium chloride

C: 440341-75-3
3-[(4-chlorobenzoyl)amino]propionic acid

Conditions

Conditions	Yield
With hydrogenchloride; nitric acid; sodium nitrite In water at 20℃; for 1h; Reagent/catalyst;	A 10% B 80% C 3%

...Expand

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 101356-82-5
1-(4-ethoxy-phenyl)-3-diethylamino-propan-1-one; hydrochloride

: 3-{4-[3-(4-ethoxyphenyl)-3-oxopropylamino]-benzamido}propanoic acid

Conditions

Conditions	Yield
In water Heating;	79%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 4300-97-4
3-Chloropivaloyl chloride

: 3-[4-(3-Chloro-2,2-dimethyl-propionylamino)-benzoylamino]-propionic acid

Conditions

Conditions	Yield
With pyridine In 1,4-dioxane for 1h; Heating;	70%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 3-Diethylamino-1-(4-isopropoxy-phenyl)-propan-1-one; hydrochloride

: 3-{4-[3-oxo-3-(4-propan-2-yloxyphenyl)propylamino]-benzamido}propanoic acid

Conditions

Conditions	Yield
In water Heating;	68%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 99-96-7
4-hydroxy-benzoic acid

: 2,4-bis[[4[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-3-[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]phenol

Conditions

Conditions	Yield
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride In water at 20 - 25℃; Stage #2: With sodium nitrite In water at -2 - 2℃; Stage #3: 4-hydroxy-benzoic acid Further stages;	36%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 5409-52-9
β-(N,N-diethylamino)-p-chloropropiophenone hyrdochloride

: 3-{4-[3-(4-chlorophenyl)-3-oxopropylamino]-benzamido}propanoic acid

Conditions

Conditions	Yield
In water Heating;	36%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 69-72-7
salicylic acid

3-[[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxybenzoic acid: 3-[[4-[[(2-carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride In water at 20 - 25℃; Stage #2: With sodium nitrite In water at 0 - 2℃; Stage #3: salicylic acid Further stages;	7%

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 1004-75-7
2,5,6-triamino-3,4-dihydro-4-pyrimidinone

: 5221-17-0
2,3-dibromopropanal

: 15677-93-7
N-pteroyl-β-alanine

Conditions

Conditions	Yield
With sodium dichromate
With iodine

...Expand

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 17832-99-4
3-(hydroxymethyl)benzo[d]oxazol-2(3H)-one

N-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-β-alanine: 67726-28-7
N-{4-[(2-oxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-β-alanine

Conditions

Conditions	Yield
In ethanol Heating;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 3161-58-8
3-(Hydroxymethyl)-2-benzoxazolinethione

: 67726-31-2
N-{4-[(2-thioxo-benzooxazol-3-ylmethyl)-amino]-benzoyl}-β-alanine

Conditions

Conditions	Yield
In ethanol Heating;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 3161-57-7
3-hydroxymethyl-3H-benzothiazole-2-thione

: 67726-34-5
N-{4-[(2-thioxo-benzothiazol-3-ylmethyl)-amino]-benzoyl}-β-alanine

Conditions

Conditions	Yield
In ethanol Heating;

: 2,5-bis-[4-(5-oxo-2-trifluoromethyl-4,5-dihydro-oxazol-4-yl)-phenoxymethyl]-benzoyl chloride

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 3-(4-{2,5-bis-[4-(5-oxo-2-trifluoromethyl-4,5-dihydro-oxazol-4-yl)-phenoxymethyl]-benzoylamino}-benzoylamino)-propionic acid

Conditions

Conditions	Yield
In dichloromethane at 4℃;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 762-42-5
dimethyl acetylenedicarboxylate

: C16H18N2O7

Conditions

Conditions	Yield
at 5 - 20℃;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: C16H16N2O6

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 5 - 20 °C 2: 75 percent / Eaton's reagent / 50 °C View Scheme

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 3-[4-(3,3-Dimethyl-2-oxo-azetidin-1-yl)-benzoylamino]-propionic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 70 percent / pyridine / dioxane / 1 h / Heating 2: 87 percent / sodium carbonate / dimethylformamide / 1 h / 160 °C View Scheme

: 50886-34-5
5-methylpyrazine-2-carbonyl chloride

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 894786-97-1
(2R,4'R,8a'R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-6'-oxotetrahydro-2'H-spiro[pyrrolidine-2,7'-pyrrole[2,1-b][1,3]thiazine]-4'-carboxylic acid

: 894787-31-6
C27H31N7O5S

Conditions

Conditions	Yield
Multistep reaction.;	5.5 mg

...Expand

: 5121-00-6
naphthalen-1-yl-acetyl chloride

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 894786-80-2
{(5S)-1-[(9H-fluoren-9-yl-methoxy)carbonyl]-6-oxo-1,7-diazaspiro[4,5]dec-7-yl}acetic acid

: 894787-21-4
N-{3-[(5R)-7-(2-amino-2-oxoethyl)-6-oxo-1,7-diazaspiro[4,5]dec-1-yl]-3-oxopropyl}-4-[(1-naphthylacetyl)amino]benzamide

Conditions

Conditions	Yield
Multistep reaction.;	3.5 mg

...Expand

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

Reaxys ID: 19845716: Reaxys ID: 19845716

Reaxys ID: 19845715: Reaxys ID: 19845715

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 4411-25-0
1-adamantyl isocyanate

: C21H27N3O4

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60 - 80℃; for 12h;

: 7377-08-4
N-(4-aminobenzoyl)-B-alanine

: 69-72-7
salicylic acid

: 5-[2-[4',5-bis[(2-carboxyethyl)carbamoyl]biphenyl-2-yl]diazenyl]-2-hydroxybenzoic acid

Conditions

Conditions	Yield
Stage #1: N-(4-aminobenzoyl)-B-alanine With hydrogenchloride In water at 20 - 25℃; Stage #2: With sodium nitrite In water at -2 - 2℃; Stage #3: salicylic acid Further stages;

N-(4-Aminobenzoyl)-beta-alanine Chemical Properties

Empirical Formula: C₁₀H₁₂N₂O₃
Molecular Weight: 208.2139 g/mol
Index of Refraction: 1.604
Density: 1.303 g/cm³
Flash Point: 267.9 °C
Enthalpy of Vaporization: 83.4 kJ/mol
Boiling Point: 519.4 °C at 760 mmHg
Vapour Pressure: 1.29E-11 mmHg at 25 °C
Melting point: 152-154 °C(lit.)
Appearance: White to light orange-brown crystalline powder
Structure of N-(4-Aminobenzoyl)-beta-alanine (CAS NO.7377-08-4):

Product Category of N-(4-Aminobenzoyl)-beta-alanine (CAS NO.7377-08-4): Balsalazide

N-(4-Aminobenzoyl)-beta-alanine Toxicity Data With Reference

N-(4-Aminobenzoyl)-beta-alanine (CAS NO.7377-08-4) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65.

N-(4-Aminobenzoyl)-beta-alanine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.

N-(4-Aminobenzoyl)-beta-alanine Specification

N-(4-Aminobenzoyl)-beta-alanine , its cas register number is 7377-08-4. It also can be called 3-(4-Amino-benzoylamino)-propionic acid ; and beta-Alanine, N-(4-aminobenzoyl)- . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
In addition, N-(4-Aminobenzoyl)-beta-alanine (CAS NO.7377-08-4) could be stable under normal temperatures and pressures, and you must not take it with strong oxidants. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases.

Product Name

N-(4-Aminobenzoyl)-beta-alanine

Synthetic route

N-(4-Aminobenzoyl)-beta-alanine Chemical Properties

N-(4-Aminobenzoyl)-beta-alanine Toxicity Data With Reference

N-(4-Aminobenzoyl)-beta-alanine Safety Profile

N-(4-Aminobenzoyl)-beta-alanine Specification

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