Product Name

  • Name

    PROTRIPTYLINE

  • EINECS 207-119-9
  • CAS No. 438-60-8
  • Density 1.026 g/cm3
  • Solubility
  • Melting Point
  • Formula C19H21 N
  • Boiling Point 407.7 °C at 760 mmHg
  • Molecular Weight 263.382
  • Flash Point 198.3 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 438-60-8 (PROTRIPTYLINE)
  • Hazard Symbols
  • Synonyms 5H-Dibenzo[a,d]cycloheptene-5-propylamine,N-methyl- (7CI,8CI); 5-(3-Methylaminopropyl)-5H-dibenzo[a,d]cycloheptene;7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene; Amimetilina; MK 240;N-3-(5H-Dibenzo[a,d]cyclohepten-5-yl)propyl-N-methylamine;N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine; Protriptyline;Protryptyline; Triptil
  • PSA 12.03000
  • LogP 4.69280

N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine Chemical Properties

Chemistry informtion about N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) is:
Synonyms: Protriptyline ; 3-(5h-Dibenzo[A,D]Cyclohepten-5-Yl)-N-Methyl-1-Propanamine ; 5-(3-Methylaminopropyl)-5h-Dibenzo[A,D]Cycloheptene ; 5h-Dibenzo[A,D]Cycloheptene-5-Propanamine, N-Methyl- ; 5h-Dibenzo[A,D]Cycloheptene-5-Propylamine, N-Methyl- ; 7-(3-Methylaminopropyl)-1,2:5,6-Dibenzocycloheptatriene ; Amimetilina ; N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine
MF: C19H21N
MW: 263.38
EINECS: 207-119-9 
Density: 1.026 g/cm3
Flash Point: 198.3 °C Boiling Point: 407.7 °C at 760 mmHg
Vapour Pressure: 7.41E-07 mmHg at 25°C
Enthalpy of Vaporization: 65.96 kJ/mol
Following is the molecular structure of N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) is:

N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine Uses

  N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain. This drug can also be used for sleep apnea treatment along with a carbonic anhydrase inhibitor.

N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 67mg/kg (67mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intravenous 30mg/kg (30mg/kg) behavioral: changes in motor activity (specific assay) Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974.
mouse LD50 oral 269mg/kg (269mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 subcutaneous 192mg/kg (192mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit LD50 intravenous 8200mg/kg (8200mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit LD50 oral 310mg/kg (310mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intraperitoneal 42mg/kg (42mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 oral 240mg/kg (240mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.

N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.

N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine Specification

N-3-(5h-Dibenzo(A,D)Cyclohepten-5-Yl)Propyl-N-Methylamine (CAS NO.438-60-8) (Vivactil) is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, and it is sometimes used in narcolepsy to achieve a wakefulness-promoting effect.[citation needed] (the other TCAs tend to be sedating and therefore are often taken in the evening).

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