Product Name

  • Name

    N-Hydroxymaleimide

  • EINECS 225-385-4
  • CAS No. 4814-74-8
  • Article Data6
  • CAS DataBase
  • Density 1.793 g/cm3
  • Solubility
  • Melting Point 130-133 °C (dec.)(lit.)
  • Formula C4H3NO3
  • Boiling Point 276.8 °C at 760 mmHg
  • Molecular Weight 113.073
  • Flash Point 121.2 °C
  • Transport Information UN 3261 8/PG 3
  • Appearance yellow to brown crystalline powder
  • Safety 26-36/37/39-45
  • Risk Codes 34-20/21/22
  • Molecular Structure Molecular Structure of 4814-74-8 (N-Hydroxymaleimide)
  • Hazard Symbols CorrosiveC
  • Synonyms Maleimide,N-hydroxy- (7CI,8CI);
  • PSA 57.61000
  • LogP -0.76150

N-Hydroxymaleimide Chemical Properties


IUPAC Name: 1-Hydroxypyrrole-2,5-dione 
Empirical Formula: C4H3NO3
Molecular Weight: 113.0715
Canonical SMILES: C1=CC(=O)N(C1=O)O
InChI: InChI=1S/C4H3NO3/c6-3-1-2-4(7)5(3)8/h1-2,8H
InChIKey: BUXKULRFRATXSI-UHFFFAOYSA-N
XLogP3-AA: -1
H-Bond Donor: 1
H-Bond Acceptor: 3 
EINECS: 225-385-4 
Index of Refraction: 1.666
Molar Refractivity: 23.46 cm3
Molar Volume: 63 cm3
Surface Tension: 104.9 dyne/cm
Density: 1.793 g/cm3
Flash Point: 121.2 °C
Enthalpy of Vaporization: 59.83 kJ/mol
Boiling Point: 276.8 °C at 760 mmHg
Vapour Pressure: 0.000581 mmHg at 25 °C
Product Categories: Miscellaneous; Heterocyclic Compounds; Heterocycles; Active Esters/Additives; Active Esters/AdditivesSynthetic Reagents; Coupling; Peptide Synthesis
Melting Point of 1H-Pyrrole-2,5-dione,1-hydroxy- (CAS NO.4814-74-8): 130-133 °C (dec.)(lit.)

N-Hydroxymaleimide Safety Profile

Hazard Codes: CorrosiveC
Risk Statements: 34-20/21/22 
R34:Causes burns. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/37/39-45 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3261 8/PG 3
WGK Germany: 3
F: 10-21
HazardClass: 8
PackingGroup of 1H-Pyrrole-2,5-dione,1-hydroxy- (CAS NO.4814-74-8): III

N-Hydroxymaleimide Specification

 1H-Pyrrole-2,5-dione,1-hydroxy- (CAS NO.4814-74-8), its Synonyms are 1-Hydroxy-1H-pyrrole-2,5-dione ; N-Hydroxymaleimide ; 1-Hydroxy-2,5-dihydro-1H-pyrrole-2,5-dione . It is yellow to brown crystalline powder.

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