N-Methylpropionamide

Reported in EPA TSCA Inventory.

The N-Methylpropionamide is an organic compound with the formula C₄H₉NO. The IUPAC name of this chemical is N-methylpropanamide. With the CAS registry number 1187-58-2, it is also named as propanamide, N-methyl-. The product's categories are Amides; Carbonyl Compounds; Organic Building Blocks. Besides, it is a clear colourless liquid, which used as a solvent.

Physical properties about N-Methylpropionamide are: (1)ACD/LogP: -0.52; (2)ACD/LogD (pH 5.5): -0.52; (3)ACD/LogD (pH 7.4): -0.52; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 12.44; (7)ACD/KOC (pH 7.4): 12.44; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 1; (11)Polar Surface Area: 20.31 Å²; (12)Index of Refraction: 1.397; (13)Molar Refractivity: 24.2 cm³; (14)Molar Volume: 100.4 cm³; (15)Polarizability: 9.59×10^-24cm³; (16)Surface Tension: 24.8 dyne/cm; (17)Density: 0.866 g/cm³; (18)Flash Point: 105.4 °C; (19)Enthalpy of Vaporization: 45.42 kJ/mol; (20)Boiling Point: 217.8 °C at 760 mmHg; (21)Vapour Pressure: 0.13 mmHg at 25°C.

Preparation: this chemical can be prepared by propionyl chloride and methylamine. This reaction will need reagent KOH and solvent H₂O.

Uses of N-Methylpropionamide: it can be used to produce N-methylthiopropanamide by heating. It will need reagent P₂S₅ and solvent benzene.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(NC)CC
(2)InChI: InChI=1/C4H9NO/c1-3-4(6)5-2/h3H2,1-2H3,(H,5,6)
(3)InChIKey: QJQAMHYHNCADNR-UHFFFAOYAI
(4)Std. InChI: InChI=1S/C4H9NO/c1-3-4(6)5-2/h3H2,1-2H3,(H,5,6)
(5)Std. InChIKey: QJQAMHYHNCADNR-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD50	unreported	1700mg/kg (1700mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.