2,3-bis(hydroxyamino)-2,3-dimethylbutane monosulfate
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 2h; Cooling with ice; Inert atmosphere; | 79.1% |
2,3-dimethyl-2,3-dinitrobutane
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
With aluminum amalgam In tetrahydrofuran; water at -7 - -2℃; for 0.75h; | 79% |
With aluminum amalgam In tetrahydrofuran; water at 0℃; for 0.333333h; | 76% |
With ammonium chloride; zinc In tetrahydrofuran at 4 - 6℃; for 16.5h; | 68% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4,4'-diformylbiphenyl
2,2'-(biphenyl-4,4'-diyl)bis(4,4,5,5-tetramethylimidazolidine-1,3-diol)
Conditions | Yield |
---|---|
In toluene for 3h; Reflux; Inert atmosphere; | 100% |
In toluene Inert atmosphere; Reflux; | 95% |
diethyl 3-formyl-1H-pyrazole-4,5-dicarboxylate
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
diethyl 3-(1,3-dihydroxy-4,4,5,5-tetramethylimidazolidin-2-yl)-1H-pyrazole-4,5-dicarboxylate
Conditions | Yield |
---|---|
In methanol for 5h; | 98% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4-hydroxy-3-nitrobenzaldehyde
2-(4-hydroxy-3-nitrophenyl)-4,4,5,5-tetramethylimidazolidine-1,3-diol
Conditions | Yield |
---|---|
In methanol at 20℃; for 3h; | 98% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
tolan-4,4'-dicarbaldehyde
Conditions | Yield |
---|---|
In toluene at 110℃; Inert atmosphere; | 98% |
In toluene Inert atmosphere; Reflux; | 98% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
In methanol at 20℃; for 48h; Sealed tube; Schlenk technique; Inert atmosphere; Darkness; | 97% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4,4'-(buta-1,3-diyne-1,4-diyl)dibenzaldehyde
Conditions | Yield |
---|---|
In toluene at 110℃; for 3h; Inert atmosphere; | 97% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
In toluene at 110℃; Inert atmosphere; | 97% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
5-formyl-2-hydroxybenzaldehyde
Conditions | Yield |
---|---|
In benzene for 21h; Heating; | 96% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
benzaldehyde
1,3-dihydroxyl-2-phenyl-4,4,5,5-tetramethylimidazolidine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol at 20℃; for 48h; | 96% |
In methanol at 20℃; for 1h; | 85% |
In methanol at 20℃; for 16h; | 85% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
o-carboxybenzaldehyde
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; Cycloaddition; | 95% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
5-bromobenzene-1,3-dicarbaldehyde
1,3-bis(1,3-dihydroxy-4,4,5,5-tetramethylimidazolin-2-yl)-5-bromobenzene
Conditions | Yield |
---|---|
In methanol at 20℃; for 72h; Condensation; | 95% |
In methanol for 72h; | 94% |
2-(4,5-dibromo-[1,3]dithiol-2-ylidene)-1,3-benzodithiol-5-carbaldehyde
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
2,3-bis(hydroxyamino)-2,3-dimethylbutane monosulfate
2-[2-(4,5-dibromo-[1,3]dithiol-2-ylidene)-1,3-benzodithiol-5-yl]-4,4,5,5-tetramethylimidazolidine-1,3-diol
Conditions | Yield |
---|---|
In methanol; benzene for 3h; Inert atmosphere; Reflux; | 95% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
With sodium periodate In dichloromethane; water at 0℃; | 94% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4-chloro-benzoyl chloride
N,N'-(1,1,2,2-Tetramethylethylen)-bis
Conditions | Yield |
---|---|
With triethylamine In benzene at 50℃; for 1h; | 94% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4-dimethylamino-benzaldehyde
1,3-dihydroxy-2-(4'-N,N-dimethylaminophenyl)-4,4,5,5-tetramethylimidazolidine
Conditions | Yield |
---|---|
With 2,3-bis(hydroxyamino)-2,3-dimethylbutane monosulfate In ethanol Heating; | 94% |
With toluene-4-sulfonic acid at 25℃; for 48h; | 73% |
In methanol at 20℃; for 16h; | 31% |
m-iodobenzaldehyde
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
1,3-dihydroxy-2-(3-iodophenyl)-4,4,5,5-tetramethylimidazolidine
Conditions | Yield |
---|---|
In methanol at 20℃; for 120h; | 94% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4-(hydroxylmethyl)benzaldehyde
Conditions | Yield |
---|---|
Stage #1: N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine; 4-(hydroxylmethyl)benzaldehyde In water at 20℃; for 24h; Stage #2: With lead dioxide In water for 2h; | 93% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
phenyl isocyanate
N,N'-(1,1,2,2-Tetramethylethylen)-bis(O-phenylcarbamoylhydroxylamin)
Conditions | Yield |
---|---|
In benzene for 0.166667h; Heating; | 92% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4-Ethynylbenzaldehyde
4-ethynyl-1-(1,3-dihydroxy-4,4,5,5-tetramethylimidazolin-2-yl)benzene
Conditions | Yield |
---|---|
In methanol at 20℃; Condensation; | 91% |
In methanol for 24h; Heating; | 78% |
In methanol for 12h; Reflux; Inert atmosphere; |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
3-tert-butyl-4,5-dimethoxybenzaldehyde
2-(3-tert-butyl-4,5-dimethoxy-phenyl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol
Conditions | Yield |
---|---|
In methanol for 12h; Heating; | 91% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol at 60 - 65℃; | 91% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
5-formyl-2-nitrophenol
2-(3-hydroxy-4-nitrophenyl)-4,4,5,5-tetramethylimidazolidine-1,3-diol
Conditions | Yield |
---|---|
In methanol at 20℃; for 3h; | 91% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
4-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-yl]-benzaldehyde
2-{4-[2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5-methylsulfanyl-[1,3]dithiol-4-yl]-phenyl}-4,4,5,5-tetramethyl-imidazolidine-1,3-diol
Conditions | Yield |
---|---|
With sulfuric acid In hexane; dichloromethane Cycloaddition; Heating; | 90% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
m,m'-bisformylbenzene-4-ethynyl-benzaldehyde
C35H52N6O6
Conditions | Yield |
---|---|
In methanol at 20℃; for 72h; Condensation; | 90% |
In methanol for 72h; | 90% |
Isophthalaldehyde
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
In methanol at 20℃; for 24h; | 90% |
5,17-diformyl-11,23-dibromo-25,26,27,28-tetrakis(2-methoxyethoxy)calix[4]arene
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
5,17-bis(1,3-dihydroxy-4,4,5,5-tetramethylimidazolidin-2-yl)-11,23-dibromo-25,26,27,28-tetrakis(2-methoxyethoxy)calix[4]arene
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol at 55 - 60℃; | 90% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Cyclohexyl isocyanate
N,N'-(1,1,2,2-Tetramethylethylen)-bis(O-cyclohexylcarbamoylhydroxylamin)
Conditions | Yield |
---|---|
In benzene for 0.166667h; Heating; | 88% |
2,5-Dihydroxybenzaldehyde
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
Conditions | Yield |
---|---|
With 2,3-dimethyl-2,3-(dihydroxylaminium)butane sulfonate; 3 A molecular sieve In methanol; benzene for 96h; | 88% |
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
2,2′-bipyridine-5,5′-dicarbaldehyde
Conditions | Yield |
---|---|
In toluene Inert atmosphere; Reflux; | 88% |
In methanol at 20℃; for 72h; Condensation; | 85% |
2-iodobenzaldehyde
N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine
1,3-dihydroxy-2-(2-iodophenyl)-4,4,5,5-tetramethylimidazolidine
Conditions | Yield |
---|---|
In methanol at 20℃; for 120h; | 88% |
The N,N'-Dihydroxy-2,3-dimethyl-2,3-butanediamine, with the CAS registry number 14384-45-3, is also known as 2,3-Di(hydroxylamino)-2,3-dimethylbutane. It belongs to the product category of Pharmacetical. This chemical's molecular formula is C6H16N2O2 and molecular weight is 148.20344. Its IUPAC name is called N-[3-(hydroxyamino)-2,3-dimethylbutan-2-yl]hydroxylamine.
Physical properties of N,N'-Dihydroxy-2,3-dimethyl-2,3-butanediamine: (1)ACD/LogP: 0.54; (2)ACD/LogD (pH 5.5): -0.96; (3)ACD/LogD (pH 7.4): 0.39; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1.09; (6)ACD/KOC (pH 5.5): 1.48; (7)ACD/KOC (pH 7.4): 33.69; (8)#H bond acceptors: 4; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 5; (11)Index of Refraction: 1.482; (12)Molar Refractivity: 40.03 cm3; (13)Molar Volume: 140.3 cm3; (14)Surface Tension: 38.9 dyne/cm; (15)Density: 1.056 g/cm3; (16)Flash Point: 123.1 °C; (17)Enthalpy of Vaporization: 59.55 kJ/mol; (18)Boiling Point: 274.6 °C at 760 mmHg; (19)Vapour Pressure: 0.000679 mmHg at 25°C.
Uses of N,N'-Dihydroxy-2,3-dimethyl-2,3-butanediamine: it can be used to produce 2,3-Di(pivaloyloxyamino)-2,3-dimethylbutan at ambient temperature. This reaction will need reagent Et3N and solvent tetrahydrofuran with reaction time of 8 hours. The yield is about 68%.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(C(C)(C)NO)NO
(2)InChI: InChI=1S/C6H16N2O2/c1-5(2,7-9)6(3,4)8-10/h7-10H,1-4H3
(3)InChIKey: INKQNCNEVLUBQP-UHFFFAOYSA-N
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