Conditions | Yield |
---|---|
With hydrogen; sodium hydroxide In ethanol at 90℃; under 15001.5 Torr; Autoclave; Green chemistry; | 85% |
With sodium; butan-1-ol | |
With ammonia; nickel at 100℃; under 73550.8 Torr; Hydrogenation; |
Bis(2-cyanoethyl)methylamine
A
1-methyl-[1,5]diazocane
B
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
With ammonia; nickel at 90 - 100℃; under 73550.8 Torr; Hydrogenation; |
3,3'-Diamino-N-methyldipropylamine
1-methyl-4-nitro-2-trichloroacetylpyrrole
1-methyl-N-[3-[methyl-[3-[(1-methyl-4-nitro-pyrrole-2-carbonyl)amino]propyl]amino]propyl]-4-nitro-pyrrole-2-carboxamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 100% |
N-(Benzyloxycarbonyloxy)succinimide
3,3'-Diamino-N-methyldipropylamine
C23H31N3O4
Conditions | Yield |
---|---|
In chloroform at 20℃; for 16h; | 100% |
In chloroform at 20℃; for 16h; | |
In chloroform at 20℃; for 16h; |
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; | 100% |
3,3'-Diamino-N-methyldipropylamine
2-chloro-3-methyl-4-quinolinecarboxylic acid chloride
C29H31Cl2N5O2
Conditions | Yield |
---|---|
With triethylamine In chloroform at 20℃; for 48h; | 98% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 98% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 98% |
3,3'-Diamino-N-methyldipropylamine
(1,1-dimethyl-2-phenylethyl) hydrogen benzene-1,2-dicarboxylate
Conditions | Yield |
---|---|
With TEA; chloroformic acid ethyl ester In dichloromethane | 97% |
3,3'-Diamino-N-methyldipropylamine
sodium nitrite
[Cu(3,3'-diamino-N-methyldipropylamine)(ONO)(H2O)]ClO4
Conditions | Yield |
---|---|
In methanol soln. of Cu salt added to soln. of org. compd., hot soln. of NaNO2 addeddropwise, heated for 10 min; hot filtered, allowed to crystallize at room temp., filtered, washed with ether, air-dried; elem. anal.; | 97% |
ethanol
3,3'-Diamino-N-methyldipropylamine
1,2-bis(4-tert-butyl-2,6-diformylphenylsulfanyl)ethane
Conditions | Yield |
---|---|
Stage #1: ethanol; 3,3'-Diamino-N-methyldipropylamine; 1,2-bis(4-tert-butyl-2,6-diformylphenylsulfanyl)ethane In dichloromethane at 0 - 20℃; for 18h; Stage #2: With sodium tetrahydroborate at 20℃; for 4h; | 97% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 97% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 97% |
3,3'-Diamino-N-methyldipropylamine
di-tert-butyl dicarbonate
N-(3-aminopropyl)-N-(3-tert-butyloxycarbonyl-aminopropyl)-N-methylamine
Conditions | Yield |
---|---|
In tetrahydrofuran | 96% |
In tetrahydrofuran | 96% |
In tetrahydrofuran | 83% |
3,3'-Diamino-N-methyldipropylamine
(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoic acid
Conditions | Yield |
---|---|
96% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In methanol soln. of NH4CNS added dropwise to mixt. of soln. of Cu salt and of org. compd., heated for 5 min; hot filtered, allowed to crystallize at room temp., filtered, washed with ether, air-dried; elem. anal.; | 96% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 96% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 96% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol for 5h; Reflux; | 96% |
(E)-3-(5,6-dimethoxy-1,1-dimethyl-2-indenyl)-2-propenoic acid
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
95% |
3,3'-Diamino-N-methyldipropylamine
Co(OCHOC6H2Cl2)2
Co((CH2)3NCHC6H2Cl2O)2NCH3
Conditions | Yield |
---|---|
In methanol under N2 soln. was refluxed for 30 min; soln. was concd. in vac., allowed to stand at room temp., prisms were collected by suction, washed with methanol, dried in vac. dessicator; elem. anal.; | 95% |
3,3'-Diamino-N-methyldipropylamine
molybdenum hexacarbonyl
fac-[(H2N(CH2)3NMe(CH2)3NH2)Mo(CO)3]
Conditions | Yield |
---|---|
In dibutyl ether N2-atmosphere; slight excess metal carbonyl, refluxing for 2 h (returning sublimed hexacarbonyl into reaction vessel); cooling to room temp., collection of ppt., washing (hexane), drying (vac., 50°C); | 95% |
3,3'-Diamino-N-methyldipropylamine
11-((3-((3-aminopropyl)(methyl)amino)propyl)amino)-7-methoxy-5-methylbenzofuro[3,2-b]quinolin-5-ium iodide
Conditions | Yield |
---|---|
at 120℃; for 0.5h; | 95% |
In 2-methoxy-ethanol at 120℃; for 0.5h; | 1.36 g |
3,3'-Diamino-N-methyldipropylamine
3,5-di-tert-butyl-2-hydroxybenzaldehyde
Conditions | Yield |
---|---|
In methanol at 20℃; for 2h; Inert atmosphere; Schlenk technique; | 94% |
In ethanol for 1h; Heating; | |
In ethanol Reflux; |
3,3'-Diamino-N-methyldipropylamine
3,4-diethoxy-3-cyclobuten-1,2-dione
3,3'-[N,N'-[(methylimino)di-3,1-propanediyldiimino]]bis(4-ethoxy-3-cyclobutene-1,2-dione)
Conditions | Yield |
---|---|
In diethyl ether at 20℃; for 12h; | 94% |
In diethyl ether at 20℃; | 74% |
In diethyl ether | |
In diethyl ether at 20℃; | |
In diethyl ether at 20℃; for 12h; Inert atmosphere; |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In ethanol | 94% |
1-chloro-7-methoxy-4-nitro-10H-acridin-9-one
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
With triethylamine In dimethyl sulfoxide at 80℃; for 3h; | 93% |
Conditions | Yield |
---|---|
In methanol at 25℃; under 759.826 Torr; | 92% |
Conditions | Yield |
---|---|
In methanol; N,N-dimethyl-formamide at 20℃; for 4h; | 91% |
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In methanol hot suspn. of NaN3 in methanol added dropwise to soln. of Cu salt and triamine in methanol; soln. quickly filtered, filtrate heated in steam bath for 5 min, soln. kept at room temp. for 1 h; crystals filtered off; washed with ether; air dried; elem. anal.; | 91% |
In water aq. soln. of NaN3 added dropwise to soln. of Cu salt and triamine in H2O; stirred for 10 min, left to crystallize at room temp.; crystals filtered off; washed with EtOH and ether; air dried; further crop of crystals from mother liquor which was kept at room temp. for 4 d; | 86% |
2,6-Bis(2-formylphenoxymethyl)pyridine
3,3'-Diamino-N-methyldipropylamine
Conditions | Yield |
---|---|
In not given 2,6-bis(2-formylphenoxymethyl)pyridine and Ho(NO3)3*nH2O were dissolved in hot MeOH or EtOH, soln. N,N-bis(3-aminopropyl)methylamine in MeOH or EtOH was added dropwise and refluxed for 3-4 h; react. mixt. was allowed to cool to room temp. and concd., Et2O was added, ppt. was filtered and dried in vacuo; elem. anal.; | 91% |
3,3'-Diamino-N-methyldipropylamine
[Co(5-methyl-1,5,9-triazanonane)(NO2)3]
Conditions | Yield |
---|---|
In water aq. soln. of ligand was added dropwise to hot aq. soln. of Co complex; filtered; heated on steam bath with stirring for 15 min; after 2 h filtered; washed (H2O, MeOH, ether); air-dried; elem. anal.; | 91% |
Reported in EPA TSCA Inventory.
The N,N-Bis(3-aminopropyl)methylamine with CAS registry number of 105-83-9 is also called 1,3-Propanediamine,N1-(3-aminopropyl)-N1-methyl-. Its EINECS registry number is 203-336-8. The IUPAC name is N'-(3-aminopropyl)-N'-methylpropane-1,3-diamine. In addition, the molecular formula is C7H19N3 and the molecular weight is 145.24. It belongs to the classes of Pharmaceutical Raw Materials; Nitrogen Compounds; Organic Building Blocks; Polyamines.
Physical properties about this chemical are: (1)ACD/LogP: -0.65; (2)ACD/LogD (pH 5.5): -5.55; (3)ACD/LogD (pH 7.4): -4.78; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 8; (11)Polar Surface Area: 9.72 Å2; (12)Index of Refraction: 1.482; (13)Molar Refractivity: 45.27 cm3; (14)Molar Volume: 158.6 cm3; (15)Polarizability: 17.94 ×10-24cm3; (16)Surface Tension: 38.1 dyne/cm; (17)Density: 0.915 g/cm3; (18)Flash Point: 102.8 °C; (19)Enthalpy of Vaporization: 49.03 kJ/mol; (20)Boiling Point: 252.9 °C at 760 mmHg; (21)Vapour Pressure: 0.0188 mmHg at 25°C.
Uses of N,N-Bis(3-aminopropyl)methylamine: it can react with 3-Anilinomethylen-2,4-chromandion to get N,N'-Bis-[(2,4-dioxochroman-3-yliden)-methylen]-1,7-diamino-4-methyl-4-aza-heptan. This reaction will need solvent dimethylformamide. The reaction time is 30 minutes at reaction temperature of 80 °C. The yield is about 86%.
When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed and can cause burns. And it is toxic by inhalation and in contact with skin During using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).
You can still convert the following datas into molecular structure:
(1)SMILES: NCCCN(CCCN)C
(2)InChI: InChI=1/C7H19N3/c1-10(6-2-4-8)7-3-5-9/h2-9H2,1H3
(3)InChIKey: KMBPCQSCMCEPMU-UHFFFAOYAW
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
rabbit | LD50 | skin | 140uL/kg (0.14mL/kg) | Union Carbide Data Sheet. Vol. 2/28/1967, | |
rat | LC50 | inhalation | 70mg/m3/4H (70mg/m3) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER | National Technical Information Service. Vol. OTS0559686, |
rat | LD50 | oral | 1540uL/kg (1.54mL/kg) | Union Carbide Data Sheet. Vol. 2/28/1967, |
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