N,N-Dibutyl-1,3-propanediamine supplier

Name
N,N-DIBUTYL-1,3-PROPANEDIAMINE
EINECS 203-059-2
CAS No. 102-83-0
Article Data14
CAS DataBase
Density 0.843 g/cm³
Solubility 10 G/L (20 ºC)
Melting Point -50 °C
Formula C₁₁H₂₆N₂
Boiling Point 204.999 °C at 760 mmHg
Molecular Weight 186.341
Flash Point 103.889 °C
Transport Information UN 2922 8/PG 3
Appearance Clear colourless liquid
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms 1,3-Propanediamine,N,N-dibutyl- (6CI,7CI,8CI,9CI);3-(Dibutylamino)-1-propylamine;3-(Dibutylamino)propylamine;3-(N,N-Di-n-butylamino)-1-aminopropane;N,N-Dibutyl-1,3-diaminopropane;N,N-Dibutyl-1,3-propanediamine;N,N-Dibutylaminopropylamine;N,N-Dibutyltrimethylenediamine;N-Aminopropyl-N,N-dibutylamine;NSC 6333;NSC 7777;
PSA 29.26000
LogP 2.93770

Synthetic route

: 5460-29-7
2-(3-bromopropyl)isoindole-1,3-dione

: 111-92-2
dibutylamine

: 102-83-0
3-dibutylaminopropylamine

Conditions

Conditions	Yield
With xylene at 140 - 150℃; Kochen des erhaltenen N-<3-Dibutylamino-propyl>-phthalimids mit konz.HCl.;
(i) xylene, (ii) aq. HCl; Multistep reaction;

: 25726-99-2
3-(dibutylamino)propanenitrile

: 102-83-0
3-dibutylaminopropylamine

Conditions

Conditions	Yield
With ethanol; sodium
With nickel at 95℃; under 2206.5 Torr; Hydrogenation;
With ethanol; nickel at 70℃; under 2942.03 Torr; Hydrogenation;
With lithium aluminium tetrahydride; diethyl ether

: 408353-88-8
N-(3-dibutylamino-propyl)-phthalimide

: 102-83-0
3-dibutylaminopropylamine

Conditions

Conditions	Yield
With hydrazine

: 111-92-2
dibutylamine

nickel: nickel

: 102-83-0
3-dibutylaminopropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: N2H4 View Scheme

: 111-92-2
dibutylamine

: 102-83-0
3-dibutylaminopropylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: Raney nickel; ethanol / 70 °C / 2942.03 Torr / Hydrogenation View Scheme
Multi-step reaction with 2 steps 2: Raney nickel / 95 °C / 2206.5 Torr / Hydrogenation View Scheme

: 50-99-7
D-glucose

: 102-83-0
3-dibutylaminopropylamine

: C17H36N2O5

Conditions

Conditions	Yield
In methanol; water at 65℃; for 0.166667h; Schiff Reaction; Inert atmosphere;	100%
In neat (no solvent) at 25℃; for 24h; Kinetics; Solvent;

: 911693-62-4
3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide

: 102-83-0
3-dibutylaminopropylamine

: 3-[2-{[3-(dibutylamino)propyl]amino}-8-(2,6-difluorophenyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-(1-methylethyl)benzamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	96%
In tetrahydrofuran at 20℃;	96%

: 10328-92-4
N-Methylisatoic anhydride

: 102-83-0
3-dibutylaminopropylamine

: 158091-49-7
N-Methyl-N'-(3-dibutylaminopropyl)anthranilic amide

Conditions

Conditions	Yield
In 1,4-dioxane at 70℃; for 8h;	94.5%

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 102-83-0
3-dibutylaminopropylamine

: 122-80-5
N-acetyl-p-phenylenediamine

: 4-(4,6-di(3-(dibutylamino)propylamino)-1,3,5-triazin-2-ylamino)phenylamine

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; N-acetyl-p-phenylenediamine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 45℃; for 1h; Stage #2: 3-dibutylaminopropylamine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 3h; Reflux; Stage #3: With hydrogenchloride; methanol; water for 2.5h; Reflux;	90%

...Expand

: 108-77-0
1,3,5-trichloro-2,4,6-triazine

: 102-83-0
3-dibutylaminopropylamine

: 122-80-5
N-acetyl-p-phenylenediamine

: 4-(4-hydroxy-6-(3-(dibutylamino)propylamino)-1,3,5-triazin-2-ylamino)phenylamine

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichloro-2,4,6-triazine; N-acetyl-p-phenylenediamine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 45℃; for 1h; Stage #2: 3-dibutylaminopropylamine With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 3h; Reflux; Stage #3: With hydrogenchloride; methanol; water for 2.5h; Reflux;	90%

...Expand

: 50-00-0
formaldehyd

: 102-83-0
3-dibutylaminopropylamine

: 60-24-2
2-hydroxyethanethiol

: N,N-dibuthyl-3-(1,5,3-oxathiazepan-3-yl)propan-1-amine

Conditions

Conditions	Yield
With samarium(III) nitrate hexahydrate In chloroform at 20℃; for 20h;	85%

...Expand

: 81-25-4
cholic acid

: 102-83-0
3-dibutylaminopropylamine

: N-[3-(dibutylamino)propyl]cholanamide

Conditions

Conditions	Yield
Stage #1: cholic acid With triethylamine In tetrahydrofuran for 0.166667h; Cooling; Stage #2: With chloroformic acid ethyl ester In tetrahydrofuran at 20℃; for 2.16667h; Cooling; Stage #3: 3-dibutylaminopropylamine In tetrahydrofuran for 3h;	84%

: 911693-58-8
3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahvdropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-propylbenzamide

: 102-83-0
3-dibutylaminopropylamine

: 3-[2-{[3-(dibutylamino)propyl]amino}-8-(2,6-difluorophenyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-4-methyl-N-propylbenzamide

Conditions

Conditions	Yield
In dichloromethane at 20℃;	83%
In dichloromethane at 20℃;	83%

: 116373-43-4
ethyl (3-ethyl-4-methyl-2-oxo-2H-1-benzopyran-7-yloxy)acetate

: 102-83-0
3-dibutylaminopropylamine

: N-(3-(dibutylamino)propyl)-2-((3-ethyl-4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetamide

Conditions

Conditions	Yield
In butan-1-ol at 20℃; for 48h;	83%

: 72875-83-3
6-iodo-2-phenyl-4Hbenzo[d][1,3]oxazin-4-one

: 102-83-0
3-dibutylaminopropylamine

: 3-(3-dibutylamino-propyl)-6-iodo-2-phenyl-3H-quinazolin-4-one

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	82%

: 78676-35-4
benzo[b]thiophene-3-carbonyl azide

: 102-83-0
3-dibutylaminopropylamine

: 1-Benzo[b]thiophen-3-yl-3-(3-dibutylamino-propyl)-urea; hydrochloride

Conditions

Conditions	Yield
In benzene Heating;	80%

: 81-30-1
1,4,5,8-naphthalenetetracarboxylic dianhydride

: 102-83-0
3-dibutylaminopropylamine

: 3436-57-5
N,N'-bis(3-N,N-dibutylaminopropyl)naphthalene-1,8:4,5-bis(dicarboxamide)

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 0.166667h; Microwave irradiation;	80%
In toluene for 3h; Substitution; Heating;	76%

: 102-83-0
3-dibutylaminopropylamine

: 163421-03-2
4-butylamino-3-ethoxycyclobut-3-ene-1,2-dione

: 1541171-05-4
3-(butylamino)-4-((3-(dibutylamino)propyl)amino)cyclobut-3-ene-1,2-dione

Conditions

Conditions	Yield
In ethanol at 20℃; for 12h; Inert atmosphere;	80%

: 128-69-8
perylene-3,4,9,10-tetracarboxylic acid 3,4:9,10-dianhydride

: 102-83-0
3-dibutylaminopropylamine

: C46H56N4O4

Conditions

Conditions	Yield
With 1H-imidazole; zinc diacetate at 160℃; for 4h; Inert atmosphere;	80%

: 5614-82-4
ethyl 2-(4-methyl-2-oxo-2-coumarin-7-yloxy)acetate

: 102-83-0
3-dibutylaminopropylamine

: N-(3-(dibutylamino)propyl)-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)acetamide

Conditions

Conditions	Yield
In butan-1-ol at 20℃; for 48h;	79%

: 66387-70-0
6-bromo-2-phenyl-4H-benzo[2,3-d]-1,3-oxazin-4-one

: 102-83-0
3-dibutylaminopropylamine

: 6-bromo-3-(3-dibutylamino-propyl)-2-phenyl-3H-quinazolin-4-one

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	75%

: 4015-11-6
2-chloro-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazole

: 102-83-0
3-dibutylaminopropylamine

: 1447727-71-0
N-(3-(dibutylamino)propyl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-amine

Conditions

Conditions	Yield
In ethanol Reflux;	73%

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 102-83-0
3-dibutylaminopropylamine

: 2-chloro-3-(3-(dibutylamino)propylamino)-1,4-naphthoquinone

Conditions

Conditions	Yield
With triethylamine In diethyl ether at 20℃; for 24h;	72%

: 64506-49-6
sofalcone

: 102-83-0
3-dibutylaminopropylamine

: (E)-N-(3-(dibutylamino)propyl)-2-(5-((3-methylbut-2-en-1-yl)oxy)-2-(3-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)acryloyl)phenoxy)acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 24h;	71%

: 102-83-0
3-dibutylaminopropylamine

: 6287-38-3
3,4-dichlorobenzaldehyde

: N,N-dibutyl-N’-(3,4-dichlorobenzyl)propane-1,3-diamine

Conditions

Conditions	Yield
Stage #1: 3-dibutylaminopropylamine; 3,4-dichlorobenzaldehyde In methanol at 20℃; for 1h; Stage #2: With methanol; sodium tetrahydroborate for 1h;	70.4%

: 102-83-0
3-dibutylaminopropylamine

: 595-29-9
camphoric anhydride

: 116597-91-2
(1R,5S)-3-[3-(dibutylamino)propyl]-1,8,8-trimethyl-3-azabicyclo[3.2.1]octane-2,4-dione

Conditions

Conditions	Yield
In ethanol Reflux;	70%
at 180℃;

: 50-00-0
formaldehyd

: 102-83-0
3-dibutylaminopropylamine

: 62478-76-6
1-Di-n-butylamino-3-dimethylamino-propan

Conditions

Conditions	Yield
With formic acid In water at 80℃; for 24h;	66.1%

: 911693-45-3
3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-N-(4-fluorophenyl)-4-methylbenzamide

: 102-83-0
3-dibutylaminopropylamine

: 3-[2-{[3-(dibutylamino)propyl]amino}-8-(2,6-difluorophenyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl]-N-(4-fluorophenyl)-4-methylbenzamide

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	66%
In tetrahydrofuran at 20℃;	66%

: 69022-46-4
10-Chloro-6-methyl-5H-pyrido<3',4':4,5>pyrrolo<2,3-g>isoquinoline

: 102-83-0
3-dibutylaminopropylamine

: 83948-04-3
N,N-Dibutyl-N'-(6-methyl-5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinolin-10-yl)-propane-1,3-diamine

Conditions

Conditions	Yield
at 160℃; for 5h;	53%

: 102-83-0
3-dibutylaminopropylamine

: 5-imino-7-(methylthio)-1,3,6-triphenyl-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

: 7-{[3-(dibutylamino)propyl]amino}-5-imino-1,3,6-triphenyl-5,6-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20 - 60℃;	50%

: 50-00-0
formaldehyd

: 102-83-0
3-dibutylaminopropylamine

: C63H53Cl2N7O20

: C75H79Cl2N9O20

Conditions

Conditions	Yield
In water; acetonitrile at 20℃; for 18h; aminomethylation; Mannich reaction;	48%

...Expand

: 913002-68-3
5'-[(cyclopropylamino)carbonyl]-4-{[(2,2-dimethylpropyl)amino]carbonyl}-3'-fluoro-2'-methyl-2-biphenylcarboxylic acid

: 102-83-0
3-dibutylaminopropylamine

: N3'-cyclopropyl-N2-[3-(dibutylamino)propyl]-N4-(2,2-dimethylpropyl)-5'-fluoro-6'-methyl-2,3',4-biphenyltricarboxamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;	48%

: 62053-05-8
7-chloro-6-(2-chloroethyl)-5-methyl-1,2,4-triazolo<1,5-a>pyrimidine

: 102-83-0
3-dibutylaminopropylamine

: 74258-31-4
Dibutyl-[3-(5-methyl-6,7-dihydro-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-8-yl)-propyl]-amine

Conditions

Conditions	Yield
With triethylamine In ethanol for 2h; Heating;	47%

: 571-60-8
1,4-Dihydroxynaphthalene

: 102-83-0
3-dibutylaminopropylamine

: 38528-41-5
2-{[3-(dibutylamino)propyl]amino}naphthalene-1,4-dione

Conditions

Conditions	Yield
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; for 6h;	38%
With cerium(III) chloride heptahydrate; triethylamine In ethanol at 20℃; for 4h;

: 102-83-0
3-dibutylaminopropylamine

: 130-15-4
[1,4]naphthoquinone

: 38528-41-5
2-{[3-(dibutylamino)propyl]amino}naphthalene-1,4-dione

Conditions

Conditions	Yield
In ethanol; dichloromethane at 20℃;	36.1%

N,N-Dibutyl-1,3-propanediamine Chemical Properties

IUPAC Name: N,N-dibutylpropane-1,3-diamine
The MF of N,N-dibutylpropane-1,3-diamine (102-83-0) is C₁₁H₂₆N₂.

The MW of N,N-dibutylpropane-1,3-diamine (102-83-0) is 186.34.
Synonyms of N,N-dibutylpropane-1,3-diamine (102-83-0): (3-Aminopropyl)dibutylamine ; 1,3-Propanediamine, N,N-dibutyl- ; 3-(Dibutylamino)propylamine
Product Categories: Pharmaceutical Raw Materials
Form: Clear colourless liquid
Index of Refraction: 1.457
EINECS: 203-059-2
Density: 0.843 g/ml
Flash Point: 103.9 °C
Boiling Point: 205 °C
Melting Point: -50 °C
Water Solubility: 10 G/L (20 ºC)
BRN: 635829

N,N-Dibutyl-1,3-propanediamine Uses

N,N-dibutylpropane-1,3-diamine (102-83-0) is used as organic synthesis intermediates.

N,N-Dibutyl-1,3-propanediamine Toxicity Data With Reference

1.	skn-rbt 100 µg/24H open	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
2.	orl-rat LD50:820 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.
3.	skn-rbt LD50:270 mg/kg	AIHAAP American Industrial Hygiene Association Journal. 23 (1962),95.

N,N-Dibutyl-1,3-propanediamine Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Dibutyl-1,3-propanediamine Safety Profile

Poison by skin contact. Moderately toxic by ingestion. A skin irritant. Ignites on contact with cellulose nitrate. When heated to decomposition it emits toxic fumes of NO_x.
Safety information of N,N-dibutylpropane-1,3-diamine (102-83-0):
Hazard Codes C,Xi
Risk Statements
34 Causes burns
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR UN 2922 8/PG 3
WGK Germany 3
RTECS TX7175000
HazardClass 8
PackingGroup II

Product Name

N,N-DIBUTYL-1,3-PROPANEDIAMINE

Synthetic route

N,N-Dibutyl-1,3-propanediamine Chemical Properties

N,N-Dibutyl-1,3-propanediamine Uses

N,N-Dibutyl-1,3-propanediamine Toxicity Data With Reference

N,N-Dibutyl-1,3-propanediamine Consensus Reports

N,N-Dibutyl-1,3-propanediamine Safety Profile

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