Product Name

  • Name

    N,N-Diethylchloroacetamide

  • EINECS 219-019-2
  • CAS No. 2315-36-8
  • Article Data53
  • CAS DataBase
  • Density 1.043 g/cm3
  • Solubility soluble in water
  • Melting Point 58 °C
  • Formula C6H12ClNO
  • Boiling Point 236.8 °C at 760 mmHg
  • Molecular Weight 149.62
  • Flash Point 77 °C
  • Transport Information UN 2810
  • Appearance clear brown liquid
  • Safety 45-38-36/37/39-28A-26-28-36
  • Risk Codes 36/37/38-26-21/22-20/21/22
  • Molecular Structure Molecular Structure of 2315-36-8 (N,N-Diethylchloroacetamide)
  • Hazard Symbols VeryT+, HarmfulXn
  • Synonyms 2-(Diethylamino)-2-oxoethylchloride;2-Chloro-N,N-diethylacetamide;CDEA;Chloro-N,N-diethylacetamide;N,N-Diethyl-2-chloroacetamide;N-(2-Chloroacetyl)diethylamine;N-(Chloroacetyl)diethylamine;NSC 1726;a-Chloro-N,N-diethylacetamide;
  • PSA 20.31000
  • LogP 1.09360

Synthetic route

diethylamine
109-89-7

diethylamine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Conditions
ConditionsYield
In dichloromethane; water at 5℃; Temperature; Solvent;100%
With triethylamine In dichloromethane at 0℃;99%
With triethylamine In 1,2-dichloro-ethane at 10 - 20℃; for 3h; Cooling with ice;95%
dichlorodiacetamide
4960-82-1

dichlorodiacetamide

diethylamine
109-89-7

diethylamine

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Conditions
ConditionsYield
With benzene
N,N-diethyl-1,2,2-trichlorovinylamine
686-10-2

N,N-diethyl-1,2,2-trichlorovinylamine

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Conditions
ConditionsYield
(i) nBuLi, (ii) H2O; Multistep reaction;
2-diethylamino-4,5-dimethyl-2,2-dipropoxy-2λ5-[1,3,2]dioxaphosphole
13348-14-6

2-diethylamino-4,5-dimethyl-2,2-dipropoxy-2λ5-[1,3,2]dioxaphosphole

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

diethyl-(1,2-dichloro-vinyl)-amine
109538-22-9

diethyl-(1,2-dichloro-vinyl)-amine

NaHCO3

NaHCO3

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

diethylamine
109-89-7

diethylamine

chloroacetic acid
79-11-8

chloroacetic acid

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Conditions
ConditionsYield
Stage #1: chloroacetic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h;
Stage #2: diethylamine With dmap In dichloromethane at 20℃;
diethylamine
109-89-7

diethylamine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

A

chloroamide

chloroamide

B

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine
...Expand
2-bromoacetyl chloride
22118-09-8

2-bromoacetyl chloride

diethylamine
109-89-7

diethylamine

A

2-bromo-N,N-diethylacetamide
2430-01-5

2-bromo-N,N-diethylacetamide

B

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Conditions
ConditionsYield
In dichloromethane at -25 - 20℃; for 3.5h;
...Expand
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

N,N-diethyl-2-iodoacetamide
78258-15-8

N,N-diethyl-2-iodoacetamide

Conditions
ConditionsYield
With sodium iodide In acetone for 48h;100%
With sodium iodide In acetone for 0.25h; Heating;
With sodium iodide In tetrahydrofuran; N,N-dimethyl-formamide for 1h; Substitution; Heating;
Multi-step reaction with 2 steps
1: 4 h / 0 - 20 °C
2: iodine
View Scheme
ethyl 2-methylene-6-(tert-butyldimethylsilyl)-5,6-epoxy-(Z)-3-hexenoate

ethyl 2-methylene-6-(tert-butyldimethylsilyl)-5,6-epoxy-(Z)-3-hexenoate

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

(1S,2S)-1-[(1Z,3E)-4-(tert-Butyl-dimethyl-silanyloxy)-buta-1,3-dienyl]-2-diethylcarbamoyl-cyclopropanecarboxylic acid ethyl ester

(1S,2S)-1-[(1Z,3E)-4-(tert-Butyl-dimethyl-silanyloxy)-buta-1,3-dienyl]-2-diethylcarbamoyl-cyclopropanecarboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 2-Chloro-N,N-diethylacetamide With lithium diisopropyl amide In tetrahydrofuran at -80℃; for 0.333333h;
Stage #2: ethyl 2-methylene-6-(tert-butyldimethylsilyl)-5,6-epoxy-(Z)-3-hexenoate In tetrahydrofuran at -80℃; for 0.25h;		100%
ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)propanoate
888740-63-4

ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-hydroxyphenyl)propanoate

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(diethylamino)-2-oxoethoxy]phenyl)propanoate

ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-[2-(diethylamino)-2-oxoethoxy]phenyl)propanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 80℃; for 4h;100%
With potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 4h;
6-chloroindole
17422-33-2

6-chloroindole

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

2-(6-chloro-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)-N,N-diethylacetamide

2-(6-chloro-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)-N,N-diethylacetamide

Conditions
ConditionsYield
Stage #1: 6-chloroindole In N,N-dimethyl-formamide at 0 - 20℃; for 0.25h;
Stage #2: 2-Chloro-N,N-diethylacetamide In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #3: trifluoroacetic anhydride In N,N-dimethyl-formamide at 0℃; for 3h;		100%
...Expand
6-hydroxy-benzothiazole-2-carboxylic acid ethyl
59587-30-3

6-hydroxy-benzothiazole-2-carboxylic acid ethyl

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

ethyl 6-[2-(diethylamino)-2-oxoethoxy]benzo[d]thiazole-2-carboxylate

ethyl 6-[2-(diethylamino)-2-oxoethoxy]benzo[d]thiazole-2-carboxylate

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone for 16h; Reflux;98.8%
With potassium carbonate; potassium iodide In acetone for 6h; Reflux;93.6%
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

6,15,24-tri-tert-butyl-9,18,27-trihydroxy<3.3.3>metacyclophane
170159-37-2

6,15,24-tri-tert-butyl-9,18,27-trihydroxy<3.3.3>metacyclophane

partial-cone-6,15,24-Tri-tert-butyl-9,18,27-tris<(N,N-diethylaminocarbonyl)methoxy><3.3.3>metacyclophane

partial-cone-6,15,24-Tri-tert-butyl-9,18,27-tris<(N,N-diethylaminocarbonyl)methoxy><3.3.3>metacyclophane

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 1h; Heating;98%
3,4,5-tris(octadecyloxy)benzyl acrylate
1019639-01-0

3,4,5-tris(octadecyloxy)benzyl acrylate

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

3,4,5-tris(octadecyloxy)benzyl 2-(diethylcarbamoyl)cyclopropanecarboxylate

3,4,5-tris(octadecyloxy)benzyl 2-(diethylcarbamoyl)cyclopropanecarboxylate

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; caesium carbonate In cyclohexane; propiononitrile at 80℃; for 18h;98%
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

5,17-dibromo-25,26,27,28-tetrahydroxy-calix[4]arene
195323-68-3

5,17-dibromo-25,26,27,28-tetrahydroxy-calix[4]arene

5,17-dibromo-25,26,27,28-tetrakis-(N,N-diethylamino-carbonylmethoxy)-calix[4]arene
415941-95-6

5,17-dibromo-25,26,27,28-tetrakis-(N,N-diethylamino-carbonylmethoxy)-calix[4]arene

Conditions
ConditionsYield
With sodium hydride; sodium iodide In N,N-dimethyl-formamide for 72h;97%
(6-methoxy-1,1,2-trimethyl-1,2-dihydronaphthalen-2-yl)methanol

(6-methoxy-1,1,2-trimethyl-1,2-dihydronaphthalen-2-yl)methanol

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

N,N-diethyl-2-((6-methoxy-1,1,2-trimethyl-1,2-dihydronaphthalen-2-yl)methoxy)acetamide

N,N-diethyl-2-((6-methoxy-1,1,2-trimethyl-1,2-dihydronaphthalen-2-yl)methoxy)acetamide

Conditions
ConditionsYield
Stage #1: (6-methoxy-1,1,2-trimethyl-1,2-dihydronaphthalen-2-yl)methanol With sodium hydride In 1,2-dimethoxyethane; mineral oil at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: 2-Chloro-N,N-diethylacetamide In 1,2-dimethoxyethane; mineral oil at 0 - 23℃; for 17h; Inert atmosphere;		97%
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

potassium thioacetate
10387-40-3

potassium thioacetate

thioacetic acid S-diethylcarbamoylmethyl ester

thioacetic acid S-diethylcarbamoylmethyl ester

Conditions
ConditionsYield
In dichloromethane at 0℃;96%
In acetone at 20℃;
In acetone at 20℃; for 1h; Inert atmosphere;
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

2-acetoxy-N,N-diethylacetamide
59875-48-8

2-acetoxy-N,N-diethylacetamide

Conditions
ConditionsYield
With silver(I) acetate; triphenylphosphine In acetonitrile at 50℃; for 48h; Inert atmosphere; Darkness;96%
6-methyl-1-(thiethan-3-yl)pyrimidine-2,4(1H,3H)-dione
1443443-01-3

6-methyl-1-(thiethan-3-yl)pyrimidine-2,4(1H,3H)-dione

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

N,N-diethyl-2-(4-methyl-2,6-dioxo-3-(thietan-3-yl)-2,3-dihydropyrimidin-1(6H)-yl)acetamide

N,N-diethyl-2-(4-methyl-2,6-dioxo-3-(thietan-3-yl)-2,3-dihydropyrimidin-1(6H)-yl)acetamide

Conditions
ConditionsYield
Stage #1: 6-methyl-1-(thiethan-3-yl)pyrimidine-2,4(1H,3H)-dione With potassium carbonate In acetonitrile at 0 - 25℃; for 0.5h; Reflux;
Stage #2: 2-Chloro-N,N-diethylacetamide In acetonitrile for 7h; Reflux;		96%
trimetazidine dihydrochloride
13171-25-0, 127881-54-3

trimetazidine dihydrochloride

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

N,N-Diethyl-2-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-acetamide
119963-52-9

N,N-Diethyl-2-[4-(2,3,4-trimethoxy-benzyl)-piperazin-1-yl]-acetamide

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 70℃;95%
5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene
157432-87-6, 288302-11-4, 288302-12-5

5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetrakis(diethylcarbamoylmethoxy)-calix<4>arene
114155-16-7, 136599-03-6

5,11,17,23-Tetra-tert-butyl-25,26,27,28-tetrakis(diethylcarbamoylmethoxy)-calix<4>arene

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide95%
With potassium carbonate; potassium iodide 1.) acetone, 2 h, 2.) reflux, 5 d; Yield given. Multistep reaction;
Stage #1: 5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene With 18-crown-6 ether; potassium carbonate In acetonitrile for 1h; Inert atmosphere;
Stage #2: 2-Chloro-N,N-diethylacetamide In acetonitrile at 80℃; for 10h; Inert atmosphere;
Stage #1: 5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 2-Chloro-N,N-diethylacetamide With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide; paraffin oil at 70℃; for 3h; Inert atmosphere;
picoline
108-89-4

picoline

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

1-[2-(diethylamino)-2-oxoethyl]-4-methylpyridinium chloride
1422532-43-1

1-[2-(diethylamino)-2-oxoethyl]-4-methylpyridinium chloride

Conditions
ConditionsYield
In ethyl acetate for 24h; Reflux;95%
5-phenyl-1,3,4-oxadiazole-2(3H)-thione
3004-42-0

5-phenyl-1,3,4-oxadiazole-2(3H)-thione

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

N,N-diethyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetamide

N,N-diethyl-2-(5-phenyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone for 8h; Heating;94%
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

5,17-dibromo-26,28-bis(phenylmethoxy)-25,27-dihydroxycalix[4]arene
275797-04-1

5,17-dibromo-26,28-bis(phenylmethoxy)-25,27-dihydroxycalix[4]arene

5,17-dibromo-25,27-dibenzyloxy-26,28-bis(diethylcarbamoylmethoxy)calix[4]arene
415941-97-8

5,17-dibromo-25,27-dibenzyloxy-26,28-bis(diethylcarbamoylmethoxy)calix[4]arene

Conditions
ConditionsYield
With sodium hydride; sodium iodide In N,N-dimethyl-formamide for 19h;94%
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

Diphenylphosphine oxide
4559-70-0

Diphenylphosphine oxide

oxide of diphenylphosphite
80413-42-9

oxide of diphenylphosphite

Conditions
ConditionsYield
With potassium hydroxide; potassium carbonate In benzene for 1h; Ambient temperature;93%
With sodium hydroxide In dichloromethane; water for 12h; Michaelis-Becker-Nylen Synthesis; Reflux;91%
With Aliquat 336; sodium hydroxide In dichloromethane at 70℃;
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

5-(2,4-dichlorophenyl)-1,3,4-oxadiazoline-2(3H)-thione
23288-92-8

5-(2,4-dichlorophenyl)-1,3,4-oxadiazoline-2(3H)-thione

2-[5-(2,4-dichloro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-N,N-diethyl-acetamide

2-[5-(2,4-dichloro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-N,N-diethyl-acetamide

Conditions
ConditionsYield
With potassium carbonate In acetone for 8h; Heating;93%
(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilylprop-2-en-1-ol
102357-25-5

(1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilylprop-2-en-1-ol

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

2-[1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-trimethylsilanyl-allyloxy]-N,N-diethyl-acetamide
799265-67-1

2-[1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2-trimethylsilanyl-allyloxy]-N,N-diethyl-acetamide

Conditions
ConditionsYield
Stage #1: (1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilylprop-2-en-1-ol With sodium hydride
Stage #2: 2-Chloro-N,N-diethylacetamide In 1,2-dimethoxyethane at -10 - 20℃; Further stages.;		93%
2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

(E)-N,N-diethyl-3-(2-nitrophenyl)acrylamide
440640-37-9

(E)-N,N-diethyl-3-(2-nitrophenyl)acrylamide

Conditions
ConditionsYield
With indium; triphenylphosphine at 150℃; for 0.0833333h; Microwave irradiation;93%
2-{[6-benzyl-3-cyano-4-(trifluoromethyl)pyridin-2-yl]thio}acetamide

2-{[6-benzyl-3-cyano-4-(trifluoromethyl)pyridin-2-yl]thio}acetamide

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

3-amino-6-benzyl-N,N-diethyl-4-trifluoromethylthieno[2,3-b]pyridine-2-carboxamide

3-amino-6-benzyl-N,N-diethyl-4-trifluoromethylthieno[2,3-b]pyridine-2-carboxamide

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 0.25h; Reflux;93%
C36H42N4O

C36H42N4O

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

C54H75N7O4

C54H75N7O4

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile for 48h; Reflux;93%
2-Iodophenol
533-58-4

2-Iodophenol

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

(2-iodophenoxy)-N,N-diethylacetamide

(2-iodophenoxy)-N,N-diethylacetamide

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 16h;92%
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
22204-53-1

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

N,N-diethylaminocarbonylmethyl 2-(6-methoxy-2-naphthyl)propionate

N,N-diethylaminocarbonylmethyl 2-(6-methoxy-2-naphthyl)propionate

Conditions
ConditionsYield
With triethylamine; sodium iodide In N,N-dimethyl-formamide at 90℃; for 2h;92%
N-[2-chloro-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide
952194-81-9

N-[2-chloro-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide

2-Chloro-N,N-diethylacetamide
2315-36-8

2-Chloro-N,N-diethylacetamide

2-[[2-chloro-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-(3,4-dimethoxy-benzenesulfonyl)-amino]-N,N-diethyl-acetamide
952195-24-3

2-[[2-chloro-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-(3,4-dimethoxy-benzenesulfonyl)-amino]-N,N-diethyl-acetamide

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃;92%
With potassium carbonate In N,N-dimethyl-formamide at 80℃;92%

N,N-Diethylchloroacetamide Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Diethylchloroacetamide Specification

The IUPAC name of N,N-Diethylchloroacetamide is 2-chloro-N,N-diethylacetamide. With the CAS registry number 2315-36-8, it is also named as Diethylamid kyseliny chloroctove. The product's categories are Industrial / Fine Chemicals; Amide; Amide Organic Building Blocks; Carbonyl Compounds; Herbicides; Pesticides & Metabolites. It is clear brown liquid which is highly toxic. When heated to decomposition it emits very toxic fumes of Cl− and NOx. So the storage environment should be well-ventilated, low-temperature and dry. Keep N,N-Diethylchloroacetamide separate from raw materials of food.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.55; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.55; (4)ACD/LogD (pH 7.4): 0.55; (5)ACD/BCF (pH 5.5): 1.54; (6)ACD/BCF (pH 7.4): 1.54; (7)ACD/KOC (pH 5.5): 47.37; (8)ACD/KOC (pH 7.4): 47.37; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.449; (13)Molar Refractivity: 38.44 cm3; (14)Molar Volume: 143.3 cm3; (15)Polarizability: 15.24×10-24 cm3; (16)Surface Tension: 31.6 dyne/cm; (17)Enthalpy of Vaporization: 47.36 kJ/mol; (18)Vapour Pressure: 0.0465 mmHg at 25°C; (19)Rotatable Bond Count: 3; (20)Exact Mass: 149.060742; (21)MonoIsotopic Mass: 149.060742; (22)Topological Polar Surface Area: 20.3; (23)Heavy Atom Count: 9; (24)Complexity: 91.1.

Preparation of N,N-Diethylchloroacetamide: It can be obtained by diethylamine and chloroacetyl chloride. This reaction needs reagents aq. NaOH, NH3 and solvent 1,2-dichloro-ethane at temperature of -15--10 °C. The reaction time is 45 min.

Uses of N,N-Diethylchloroacetamide: It is used as intermediate of pharmaceutical and as raw material of polyurethane additive. It is also used in organic synthesis. For example: it can react with phosphorous acid triethyl ester to get (diethylcarbamoyl-methyl)-phosphonic acid diethyl ester. This reaction must react at temperature of 180 °C for 8 hours. The yield is 84.2%.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After contact with skin, wash immediately with plenty of soap-suds. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of insufficient ventilation, wear suitable respiratory equipment. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure. 
1. SMILES:ClCC(=O)N(CC)CC
2. InChI:InChI=1/C6H12ClNO/c1-3-8(4-2)6(9)5-7/h3-5H2,1-2H3
3. InChIKey:CQQUWTMMFMJEFE-UHFFFAOYAF

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LC50 inhalation 175mg/m3/4H (175mg/m3) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 35(6), Pg. 36, 1991.
mouse LC50 inhalation 270mg/m3/2H (270mg/m3) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 35(6), Pg. 36, 1991.
mouse LD50 oral 226mg/kg (226mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 35(6), Pg. 36, 1991.
rat LC50 inhalation 315mg/m3/4H (315mg/m3) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 35(6), Pg. 36, 1991.
rat LD50 oral 500mg/kg (500mg/kg)   Residue Reviews. Vol. 10, Pg. 97, 1965.
rat LD50 skin 980mg/kg (980mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 33(2), Pg. 51, 1989.

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