N-PHENYLPHTHALIMIDE

The IUPAC name of N-Phenylphthalimide is 2-phenylisoindole-1,3-dione. With the CAS registry number 520-03-6, it is also named as 1H-Isoindole-1,3(2H)-dione, 2-phenyl-. The product's categories are Heterocyclic Compounds; Derivatives of Phthalimide; Carbonyl Compounds; Cyclic Imides; Organic Building Blocks. Besides, it is white crystalline powder, which should be stored in a cool, dry, well ventilated warehouse. In addition, its molecular formula is C₁₄H₉NO₂ and molecular weight is 223.23.

The other characteristics of this product can be summarized as: (1)EINECS: 208-282-9; (2)ACD/LogP: 2.40; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 2.4; (5)ACD/LogD (pH 7.4): 2.4; (6)ACD/BCF (pH 5.5): 39.26; (7)ACD/BCF (pH 7.4): 39.26; (8)ACD/KOC (pH 5.5): 481.5; (9)ACD/KOC (pH 7.4): 481.5; (10)#H bond acceptors: 3; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 1; (13)Index of Refraction: 1.667; (14)Molar Refractivity: 62.08 cm³; (15)Molar Volume: 166.7 cm³; (16)Surface Tension: 59.3 dyne/cm; (17)Density: 1.338 g/cm³; (18)Flash Point: 182.6 °C; (19)Melting Point: 204-207 °C; (20)Water Solubility: 295 mg/L at 25 °C; (21)Enthalpy of Vaporization: 63.8 kJ/mol; (22)Boiling Point: 388.8 °C at 760 mmHg; (23)Vapour Pressure: 2.99E-06 mmHg at 25 °C.

Preparation of N-Phenylphthalimide: this chemical can be prepared by the reaction of Phthalic anhydride with Aniline.



This reaction will occur by microwave irradiation for 3 min. The yield is 93 %.

Uses of N-Phenylphthalimide: this chemical is the intermediate of Indoprofen. Additionally,  it can be used to get 3-Hydroxy-2-phenyl-2,3-dihydro-isoindol-1-one.



This reaction needs NaBH₄, Methanol, Tetrahydrofuran at temperature of 0-5 °C for 2 hours. The yield is 90 %.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C2c1ccccc1C(=O)N2c3ccccc3
(2)InChI: InChI=1/C14H9NO2/c16-13-11-8-4-5-9-12(11)14(17)15(13)10-6-2-1-3-7-10/h1-9H
(3)InChIKey: MFUPLJQNEXUUDW-UHFFFAOYAY

The toxicity data is as follows: