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-
Name
Narcotine
- EINECS 204-899-2
- CAS No. 128-62-1
- Article Data26
- CAS DataBase
- Density 1.333 g/cm3
- Solubility 302.9mg/L(25 oC)
- Melting Point 174-176 °C(lit.)
- Formula C22H23NO7
- Boiling Point 565.316 °C at 760 mmHg
- Molecular Weight 413.427
- Flash Point 295.692 °C
- Transport Information UN 1544
- Appearance Crystalline solid
- Safety 24/25
- Risk Codes 22
-
Molecular Structure
-
Hazard Symbols
Xn
- Synonyms 1(3H)-Isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[S-(R*,S*)]-;Narcotine (7CI,8CI);(-)-Narcotine;(-)-a-Narcotine;Capval;Coscopin;L-a-Noscapine;Longactin;Longatin;Methoxyhydrastine;NSC 5366;Narcompren;Narcosine;Narcotin;Narcotussin;Nectadon;Nicolane;Nipaxon;Noscapin;Noscapine;Opian;Opianin;Opianine;Tusscapine;Vadebex;a-Narcotine;
- PSA 84.48000
- LogP 2.86840
Narcotine Chemical Properties
Product Name: Narcotine (128-62-1)
Molecular Formula: C22H23NO7
Molecular Weight: 413.42g/mol
Mol File: 128-62-1.mol
Einecs: 204-899-2
Melting Point: 174-176 °C(lit.)
Alpha: -200 ° (c=1 in chloroform)
Boiling point: 565.3°C at 760mmHg
Density: 1.332g/cm3
Product Categories: Intermediates and Fine Chemicals; Pharmaceuticals; Asymmetric Synthesis; Chiral Building Blocks; Complex Molecules
Synonyms of Narcotine (128-62-1): 2,3,4-tetrahydroisoquinaline ; [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone ; 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]- ; 1-alpha-Narcotine ; 5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4;5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4;6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one ; 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1(3h)-isobenzofuranon .
Narcotine Uses
Bronchial spasm of antitussives.
Narcotine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | intravenous | 73200ug/kg (73.2mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 323, 1968. |
| mouse | LD50 | intraperitoneal | 960mg/kg (960mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982. | |
| mouse | LD50 | intravenous | 83mg/kg (83mg/kg) | Toxicology and Applied Pharmacology. Vol. 3, Pg. 96, 1961. | |
| mouse | LD50 | oral | 853mg/kg (853mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982. | |
| mouse | LD50 | subcutaneous | 725mg/kg (725mg/kg) | Russian Pharmacology and Toxicology Vol. 31, Pg. 338, 1968. | |
| rat | LD50 | oral | 1520mg/kg (1520mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982. |
Narcotine Safety Profile
Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. An antitussive. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Narcotine (128-62-1):
Hazard Codes: Xn.gif){kind=small}
Risk Statements: 22
22: Harmful if swallowed
Narcotine Specification
Narcotine (128-62-1) is a colorless crystalline powder or glossy prism-like or flaky crystal; odorless, tasteless. Is almost insoluble in water, slightly soluble in alcohol and ether, soluble in chloroform.
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