Nefazodone

Molecular Formula: C₂₅H₃₂ClN₅O₂
Molecular Weight: 470.01
Index of Refraction: 1.616 
Density: 1.23 g/cm³ 
Flash Point: 316.4 °C 
Melting Point: 180-182°C
Appearance: white solid
Solubility: DMSO: ~11 mg/mL at 60 °C
Enthalpy of Vaporization: 89.26 kJ/mol 
Boiling Point: 599.6 °C at 760 mmHg 
Vapour Pressure: 2.46E-14 mmHg at 25°C 
IUPAC Name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
Synonyms: 3H-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy;l)-5-ethyl-4-(2-phenoxyethyl)- ; BMY-13754 ; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride ; Serzone ; MJ-13754-1 ; Nefazodone ; Nefazodone base
Following is the molecular structure of Nefazodone hydrochloride (83366-66-9):

 

The toxicity of Nefazodone hydrochloride (83366-66-9):

Safety Information of Nefazodone hydrochloride (83366-66-9):
Safety Statements: 22-24/25
22: Do not breathe dust 
24/25: Avoid contact with skin and eyes 
WGK Germany: 3
 
 

Side effects of Nefazodone hydrochloride (83366-66-9): Unlike most serotonin reuptake inhibitors, Nefazodone usually has no negative effects on libido or sexual functioning, and is actually sometimes used as an antidote to SSRI or SNRI induced impotence and anorgasmia in men. More serious side effects include an allergic reaction, fainting, or painful/prolonged erection. Less serious reactions of nefazodone include dizziness, lightheadedness, fatigue, upset stomach, insomnia; dry mouth; constipation; or blurred/abnormal vision.
Advantages of Nefazodone hydrochloride (83366-66-9): Nefazodone, though an antidepressant, may also be beneficial in the prophylaxis of migraines due to its antagonistic effects on the 5-HT2A and 5-HT2C receptors It has a more favorable side effect profile than amitriptyline, a tricyclic antidepressant commonly used for migraine prophylaxis.