Product Name

  • Name

    3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

  • EINECS 237-148-2
  • CAS No. 13669-70-0
  • Article Data8
  • CAS DataBase
  • Density 1.064 g/cm3
  • Solubility
  • Melting Point
  • Formula C17H19NO
  • Boiling Point 369.526 °C at 760 mmHg
  • Molecular Weight 253.344
  • Flash Point 109 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 13669-70-0 (3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene)
  • Hazard Symbols
  • Synonyms 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine;Fenazoxine;Nefopam;
  • PSA 12.47000
  • LogP 3.17590

Nefopam Chemical Properties

IUPAC Name: 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine
The MF of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is C17H19NO.

                                       
The MW of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is 253.34.
Synonyms of 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0): 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl- ; 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine ; Sinalgico 
Product Categories: active pharmaceutical ingredients
Apperance: white crystalline powder of its hydrochloride salt
Index of Refraction: 1.563 
EINECS: 237-148-2
Density: 1.064 g/ml 
Flash Point: 109 °C
Boiling Point: 369.5 °C

Nefopam Uses

  5-Methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine (CAS NO.13669-70-0) is non-narcotic analgesic drugs, both the role of muscle relaxants. Applicable to a variety of post-operative pain, cancer pain, visceral smooth muscle cramps and so on.

Nefopam Production

Raw materials: Thionyl chloride-->p-Toluenesulfonic acid-->Hydrogen bromide-->Activated carbon-->Potassium borohydride-->Benzoic acid-->Benzophenone-->PARA TOLUENE-->Benzhydrol

Nefopam Toxicity Data With Reference

1.    

orl-wmn TDLo:15 mg/kg:CNS,CVS

     BMJOAE    British Medical Journal. 283 (1981),1508.
2.    

orl-man TDLo:17 mg/kg:CNS,CVS

     BMJOAE    British Medical Journal. 283 (1981),1508.
3.    

orl-rat LD50:178 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
4.    

ivn-rat LD50:28 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
5.    

ims-rat LD50:57 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
6.    

orl-mus LD50:119 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
7.    

ipr-mus LD50:50 mg/kg

     DDEVD6    Drug Development and Evaluation. 3 (1979),10.
8.    

ivn-mus LD50:45 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
9.    

ims-mus LD50:53 mg/kg

     DRUGAY    Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. 19 (1980),249.
10.      

Nefopam Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, excitement, motor activity changes, increased pulse rate without blood pressure fall and heart rate changes. When heated to decomposition it emits toxic fumes of NOx.

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View