Neoarsphenamine supplier | CasNO.457-60-3

Name
Neoarsphenamine
EINECS 207-273-7
CAS No. 457-60-3
Density g/cm³
Solubility
Melting Point
Formula C13H14 As2 N2 O4 S . Na
Boiling Point °Cat760mmHg
Molecular Weight 466.17
Flash Point °C
Transport Information
Appearance
Safety Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NO_x, Na₂O, and SO_x. See also ARSENIC COMPOUNDS.
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Methanol,[5-[(3-amino-4-hydroxyphenyl)arseno]-2-hydroxyanilino]-, 1-(hydrogensulfoxylate) (ester), monosodium salt (8CI); Sulfoxylic acid,mono[[[5-[(3-amino-4-hydroxyphenyl)diarsenyl]-2-hydroxyphenyl]amino]methyl]ester, monosodium salt (9CI); Neo-I.C.I.; Neoarsphenamine; Neosalvarsan;Novarsenobenzol; Novarsenobillon; Novarsenol; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-methylene-sulfoxylate; Sodiump,p'-dihydroxy-m,m'-diaminoarsenobenzene-N-monomethanol sulfoxylate
PSA 137.85000
LogP 0.94760

Neoarsphenamine Chemical Properties

IUPAC Name: Sodium [5-(3-amino-4-hydroxyphenyl)arsanylidenearsanyl-2-hydroxyanilino]methanesulfinate
Synonyms of Neosalvarsan (CAS NO.457-60-3): ((5-(3-Amino-4-hydroxyphenyl)arseno)-2-hydroxyanilino)methanol sulfoxylate sodium ; 3,3'-Diamino-4,4'-dihydroxyarsenobenzenemethylenesulfoxylate sodium ; Arsevan ; Arsphenamine methylenesulfoxylic acid sodium salt ; Neo-gargarol liquidum ; Sodium 3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate ; Sulfoxylic acid, mono(((5-((3-amino-4-hydroxyphenyl)diarsenyl)-2-hydroxyphenyl)amino)methyl) ester, monosodium salt
CAS NO: 457-60-3
Molecular Formula: C₁₃H₁₃As₂N₂NaO₄S
Molecular Weight : 466.15
Molecular Structure:
EINECS: 207-273-7
Appearance: Yellow powder or granules.
Water solubility: Soluble in water, insoluble in alcohol, chloroform and ether.

Neoarsphenamine History

Neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. They were replaced for this indication by penicillin in the 1940s, because both of these arsenicals carried considerable risk of side-effects. It became available in 1912 and superseded the more toxic and less water-soluble salvarsan as an effective treatment for syphilis.

Neoarsphenamine Uses

Neosalvarsan (CAS NO.457-60-3) is used as an effective treatment for syphilis.

Neoarsphenamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intraperitoneal	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
guinea pig	LDLo	subcutaneous	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
mouse	LD50	intravenous	370mg/kg (370mg/kg)		Therapie. Vol. 2, Pg. 28, 1947.
mouse	LDLo	intraperitoneal	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
mouse	LDLo	subcutaneous	100mg/kg (100mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rabbit	LDLo	intravenous	150mg/kg (150mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rat	LD50	intravenous	318mg/kg (318mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 73, Pg. 12, 1941.
rat	LDLo	intraperitoneal	50mg/kg (50mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rat	LDLo	subcutaneous	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.

Neoarsphenamine Consensus Reports

Arsenic and its compounds are on the Community Right-To-Know List.

Neoarsphenamine Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 22
R22: Neosalvarsan (CAS NO.457-60-3) is harmful if swallowed.
Safety Statements: 24/25-36
S24/25: Avoid contact with skin and eyes.
S36: Wear suitable protective clothing.

Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NO_x, Na₂O, and SO_x. See also ARSENIC COMPOUNDS.

Neoarsphenamine Standards and Recommendations

OSHA PEL: TWA 0.5 mg(As)m³
ACGIH TLV: BEI: 35 µ (As)/L inorganic arsenic and methylated metabolites in urine

Neoarsphenamine Specification

Neosalvarsan (CAS NO.457-60-3) is easily oxidized in the air,and accelerate oxidation when the temperature is high .

Product Name

Neoarsphenamine