ACETYLNEURAMINYL HYDROLASE

Molecule structure of Neuraminidase (CAS NO.9001-67-6) :


Density:1.00 g/mL at 20 °C
Appreance:  white lyophilized powder
Storage temp.: 2-8 °C
EINECS: 232-624-6

 

 Neuraminidase (CAS NO.9001-67-6) enzymes are glycoside hydrolase enzymes (EC 3.2.1.18) which cleave the glycosidic linkages of neuraminic acids. Neuraminidase enzymes are a large family, found in a range of organisms. The most commonly known neuraminidase is the viral neuraminidase, a drug target for the prevention of influenza infection. The viral neuraminidases are frequently used as an antigenic determinants found on the surface of the Influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologs are found in mammalian cells which have a range of functions. At least four mammalian sialidase homologs have been described in the human genome (see NEU1, NEU2, NEU3, NEU4).
Neuraminidases catalyze the hydrolysis of terminal sialic acid residues from the newly formed virions and from the host cell receptors. Sialidase activities include assistance in the mobility of virus particles through the respiratory tract mucus and in the elution of virion progeny from the infected cell.

Reported in EPA TSCA Inventory.

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
Safety Statements: 22-24/25
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
WGK Germany: 3
RTECS: QQ3450000
F: 3-10

 Neuraminidase (CAS NO.9001-67-6) is also called E.C. 3.2.1.18 ; Sialidase ; Vibrio cholerae neuraminidase ; alpha-Neuraminidase. There are two major classes of Neuraminidase (CAS NO.9001-67-6) that cleave exo or endo poly-sialic acids:Exo hydrolysis of α-(2→3)-, α-(2→6)-, α-(2→8)-glycosidic linkages of terminal sialic acid residues; Endo hydrolysis of (2→8)-α-sialosyl linkages in oligo- or poly(sialic) acids.