IUPAC Name: Nitrosourea
Synonyms of Nitrosourea (CAS NO.13010-20-3) :1-Nitrosoharnstoff ; 1-Nitrosourea ; Urea, N-nitroso- ; N-Nitrosourea
InChI:InChI=1/CH3N3O2/c2-1(5)3-4-6/h(H3,2,3,5,6)
CAS NO:13010-20-3
Molecular Formula:C5H9N3O4
Molecular Weight :175.1427
Molecular Structure :
Index of Refraction:1.608
Surface Tension: 91.7 dyne/cm
Density: 1.82 g/cm3
1. | cyt-mus-ipr 3200 µg/kg | MUREAV Mutation Research. 38 (1976),106. | ||
2. | spm-mus-ipr 3200 µg/kg | MUREAV Mutation Research. 38 (1976),106. |
Mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Nitrosourea (CAS NO.13010-20-3) compounds are DNA alkylating agents and are often used in chemotherapy. Nitrosourea (CAS NO.13010-20-3) compounds are lipophilic and thus can cross the blood-brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme
Some Nitrosoureas (e.g. Lomustine) have been associated with the development of interstitial lung disease.
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