nylidrin hydrochloride
Conditions | Yield |
---|---|
With 3% Pd/C; hydrogen In methanol at 20℃; | 95% |
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone
(RS)-1-methyl-3-phenylpropylamine
nylidrin hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / ethyl acetate / 5 h / Reflux 2: 3% Pd/C; hydrogen / methanol / 20 °C View Scheme |
Product Name: Dilatol hydrochloride (CAS NO.849-55-8)
Molecular Formula: C19H26ClNO2
Molecular Weight: 335.87g/mol
Mol File: 849-55-8.mol
Einecs: 212-701-0
Boiling point: 476 °C at 760 mmHg
Flash Point: 127.3 °C
Enthalpy of Vaporization: 77.91 kJ/mol
Vapour Pressure: 7.23E-10 mmHg at 25°C
H-Bond Donor: 4
H-Bond Acceptor: 3
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 136mg/kg (136mg/kg) | Yakkyoku. Pharmacy. Vol. 24, Pg. 431, 1973. | |
mouse | LD50 | intravenous | 40mg/kg (40mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972. | |
mouse | LD50 | oral | 250mg/kg (250mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972. | |
rat | LD50 | intraperitoneal | 380mg/kg (380mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 351, 1972. | |
rat | LD50 | intravenous | 37400ug/kg (37.4mg/kg) | United States Patent Document. Vol. #3542870, | |
rat | LD50 | oral | > 4800mg/kg (4800mg/kg) | Drugs in Japan Vol. 6, Pg. 538, 1982. |
Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Safety Information of Dilatol hydrochloride (CAS NO.849-55-8):
Hazard Codes: Xn
Risk Statements: 20/21/22
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing
Dilatol hydrochloride ,its CAS NO. is 849-55-8,the synonyms is 1-p-Hydroxyphenyl-2-(1'-methyl-3'-phenylpropylamino)-1-propanolhydrochloride ; Arlidinhydrochloride ; Bupheninehydrochloride ; Dilatolhydrochloride ; Dilatyl ; p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-benzylalcohohyd ; p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzylalcoholhydro ; Suprifenpsbhydrochloride .
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