Product Name

  • Name

    Oxatomide

  • EINECS 262-320-9
  • CAS No. 60607-34-3
  • Article Data2
  • CAS DataBase
  • Density 1.175 g/cm3
  • Solubility DMSO: soluble
  • Melting Point 153.60C
  • Formula C27H30N4O
  • Boiling Point 621.1 °C at 760 mmHg
  • Molecular Weight 426.561
  • Flash Point 329.4 °C
  • Transport Information
  • Appearance White powder
  • Safety 26-36
  • Risk Codes 22-36/37/38
  • Molecular Structure Molecular Structure of 60607-34-3 (Oxatomide)
  • Hazard Symbols IrritantXi; HarmfulXn
  • Synonyms Celtect;Cobiona;Dasten;KW 4354;NSC 309710;Oxatomide;R 35443;Tinset;
  • PSA
  • LogP

Oxatomide Chemical Properties

Molecular Formula: C27H30N4O
Molecular Weight: 426.55 
EINECS: 262-320-9
Density: 1.175 g/cm3
Flash Point: 329.4 °C
Melting Point: 153.6 °C
Appearance: White powder.
Enthalpy of Vaporization: 95.4 kJ/mol 
Boiling Point: 621.1 °C at 760 mmHg 
Vapour Pressure: 5.1E-16 mmHg at 25°C
Solubility: DMSO: soluble Insoluble in water
Stability of Oxatomide (60607-34-3): Stable at normal temperatures and pressures.
Synonyms: Oxatomide ; 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2h-benzimidazol-2 ; 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone ; 1,3-Dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2h-benzimidazol-2-on ; 2H-benzimidazol-2-one,1,3-Dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propy ; KW-4354 ; Oxatimide
Product Categories: Intermediates & Fine Chemicals ; Pharmaceuticals
Following is the molecular structure of Oxatomide (60607-34-3):

 

Oxatomide Uses

Usage of Oxatomide (60607-34-3): Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action
Safety Information of Oxatomide (60607-34-3):
Hazard Codes: Xn,Xi
Xi: Irritant Xn: Harmful
Risk Statements: 22-36/37/38
22: Harmful if swallowed 
36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36: Wear suitable protective clothing 
WGK Germany: 3
RTECS: DE2276000

Oxatomide Toxicity Data With Reference

1.    

orl-rat LD50:1410 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),2769.
2.    

ipr-rat LD50:63 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),2769.
3.    

ivn-rat LD50:29 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),2769.
4.    

orl-mus LD50:9596 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),2769.
5.    

ipr-mus LD50:7926 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),2769.
6.    

ivn-mus LD50:25 mg/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (1984),2769.
7.    

orl-gpg LD50:320 mg/kg

    DRFUD4    Drugs of the Future. 3 (1978),465.
8.    

ivn-gpg LD50:23 mg/kg

    DRFUD4    Drugs of the Future. 3 (1978),465.

Oxatomide Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx.

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