• Name

  Oxethazaine

• EINECS 204-780-5
• CAS No. 126-27-2
• Density 1.094 g/cm³
• Solubility <0.1 g/100 mL at 23 °C in water
• Melting Point 104-105°C
• Formula C₂₈H₄₁N₃O₃
• Boiling Point 630.412 °C at 760 mmHg
• Molecular Weight 467.652
• Flash Point 335.062 °C
• Transport Information
• Appearance White powder
• Safety 36
• Risk Codes 22
• Molecular Structure
• Hazard Symbols Xn
• Synonyms Acetamide,2,2'-[(2-hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methyl-(6CI,7CI,8CI);2,2'-[(2-Hydroxyethyl)imino]bis[N-(a,a-dimethylphenethyl)-N-methylacetamide];2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol;Betalgil;FH099;Mucoxin;Oxaine;Oxetacaine;Storocain;Storocaine;Topicain;
• PSA 64.09000
• LogP 3.24010

Synthetic route

26187-18-8

2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide

141-43-5

ethanolamine

126-27-2

oxethazaine

Conditions

Conditions	Yield
With potassium carbonate; butan-1-ol

2293-55-2

chloro-acetic acid-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

141-43-5

ethanolamine

126-27-2

oxethazaine

Conditions

Conditions	Yield
With potassium carbonate In butan-1-ol

100-92-5

mephentermine

126-27-2

oxethazaine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene 2: K2CO3 / butan-1-ol View Scheme

126-27-2

oxethazaine

108-24-7

acetic anhydride

103170-15-6

(2-acetoxy-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Conditions

Conditions	Yield
In benzene Heating;
With potassium carbonate; toluene

902-47-6

p-nitrobenzoic anhydride

126-27-2

oxethazaine

97615-58-2

[2-(4-nitro-benzoyloxy)-ethylimino]-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Conditions

Conditions	Yield
In benzene Heating;

645-66-9

lauric anhydride

126-27-2

oxethazaine

Ester aus Dodecansaeure u. 2-Hydroxy-aethylimino-bis-

Conditions

Conditions	Yield
In benzene Heating;

13222-85-0

p-methylbenzoic anhydride

126-27-2

oxethazaine

Ester aus 4-Methyl-benzoesaeure u. 2-Hydroxy-aethylimino-bis-

Conditions

Conditions	Yield
In benzene Heating;

126-27-2

oxethazaine

4-aminobenzoic anhydride

4-Amino-benzoic acid 2-(bis-{[(1,1-dimethyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-amino)-ethyl ester

Conditions

Conditions	Yield
In benzene Heating;

126-27-2

oxethazaine

N.N-Bis-

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether

126-27-2

oxethazaine

115916-47-7

(2-chloro-ethylimino)-di-acetic acid bis-[(1,1-dimethyl-2-phenyl-ethyl)-methyl-amide]

Conditions

Conditions	Yield
With thionyl chloride In chloroform

126-27-2

oxethazaine

794-94-5

p-Methoxybenzoic anhydride

Ester aus 4-Methoxy-benzoesaeure u. 2-Hydroxy-aethylimino-bis-

Conditions

Conditions	Yield
In benzene Heating;

126-27-2

oxethazaine

790-41-0

4-chlorobenzoic anhydride

Ester aus 4-Chlor-benzoesaeure u. 2-Hydroxy-aethylimino-bis-

Conditions

Conditions	Yield
In benzene Heating;

126-27-2

oxethazaine

A

100-92-5

mephentermine

B

119483-39-5

<2-Hydroxy-aethyl>-

C

N-(1,1-Dimethyl-2-phenyl-ethyl)-N-methyl-2-(2-oxo-morpholin-4-yl)-acetamide

D

[{[(1,1-Dimethyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-(2-hydroxy-ethyl)-amino]-acetic acid

E

N-(1,1-Dimethyl-2-phenyl-ethyl)-2-[(2-hydroxy-ethyl)-methylcarbamoylmethyl-amino]-N-methyl-acetamide

Conditions

Conditions	Yield
at 90℃; for 2184h; Product distribution; other temperatures, other times, also in acidic solutions; stability under various conditions;

...Expand

126-27-2

oxethazaine

2-Amino-aethylimino-bis-

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / CHCl3 2: NH3 / methanol View Scheme

Oxethazaine Chemical Properties

Oxethazaine Toxicity Data With Reference

Oxethazaine Safety Profile

Oxethazaine Specification