-
Name
CHOLINE THIEOPHYLLINATE
- EINECS 224-798-7
- CAS No. 4499-40-5
- Density
- Solubility
- Melting Point 176-178 °C
- Formula C7H7N4O2•C5H14NO
- Boiling Point
- Molecular Weight 283.38
- Flash Point
- Transport Information
- Appearance
- Safety
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Theocolin (TN);Cholecystokinin receptorsCholedyl SA;Choline Theophyllinate B.P. / U.S.P.;Sabidal;Teovent;Choline theophylline;Oxtriphylline (USP);1,3-dimethyl-2-oxo-purin-6-olate; 2-hydroxyethyl-trimethyl-azanium;Choline theophylline (JAN);Ethanaminium,2-hydroxy-N,N,N-trimethyl-,salt with 3,7-dihydro-1,3-dimethyl-1Hpurine- 2,6-dione (1:1);Theocolin;Choline theophyllinate;
- PSA 90.01000
- LogP -1.72570
Oxtriphylline Chemical Properties
Chemistry informtion about Choline, With Theophylline (1:1) (CAS NO.4499-40-5) is:
IUPAC Name: 1,3-Dimethyl-2-Oxopurin-6-Olate ; 2-Hydroxyethyl(Trimethyl)Azanium
Synonyms: Oxtriphylline ; (2-Hydroxyethyl)Trimethylammoniumcompoundwiththeophylline ; Choledyl;Choledylsa400 ; Cholegyl ; Choline,Compd.Withtheophylline(1:1) ; Cholinetheophyllinesalt ; Cholinophylline
MF: C12H21N5O3
MW: 283.33
EINECS: 224-798-7
Boiling Point: 454.1°Cat760mmHg
Flash Point: 228.4°C
Following is the molecular structure of Choline, With Theophylline (1:1) (CAS NO.4499-40-5) is:
Oxtriphylline Production
Raw materials: Choline hydroxide --> Theophylline
Oxtriphylline Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intramuscular | 185mg/kg (185mg/kg) | Compilation of LD50 Values of New Drugs. | |
| guinea pig | LD50 | intravenous | 118mg/kg (118mg/kg) | Compilation of LD50 Values of New Drugs. | |
| guinea pig | LD50 | oral | 210mg/kg (210mg/kg) | Compilation of LD50 Values of New Drugs. | |
| infant | TDLo | oral | 113mg/kg/31D (113mg/kg) | endocrine: hyperglycemia kidney, ureter, and bladder: other changes in urine composition | Archives of Disease in Childhood. Vol. 53, Pg. 757, 1978. |
| man | TDLo | oral | 429mg/kg (429mg/kg) | endocrine: hyperglycemia | American Journal of Emergency Medicine. Vol. 3, Pg. 408, 1985. |
| mouse | LD50 | intramuscular | 360mg/kg (360mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | intravenous | 112mg/kg (112mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | oral | 770mg/kg (770mg/kg) | Compilation of LD50 Values of New Drugs. | |
| rat | LD50 | intramuscular | 240mg/kg (240mg/kg) | Drugs in Japan Vol. 6, Pg. 278, 1982. | |
| rat | LD50 | intraperitoneal | 185mg/kg (185mg/kg) | Drugs in Japan Vol. 6, Pg. 278, 1982. | |
| rat | LD50 | oral | 600mg/kg (600mg/kg) | Drugs in Japan Vol. 6, Pg. 278, 1982. | |
| women | TDLo | oral | 420mg/kg (420mg/kg) | behavioral: tremor behavioral: excitement gastrointestinal: nausea or vomiting | Southern Medical Journal. Vol. 71, Pg. 965, 1978. |
Oxtriphylline Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: changes in potassium, changes in urine composition, hyperglycemia, metabolic acidosis, nausea or vomiting, tremors, and excitement. When heated to decomposition it emits toxic fumes of NOx and NH3. See also THEOPHYLLINE and CHOLINE.
Oxtriphylline Specification
Properties about Choline, With Theophylline (1:1) (CAS NO.4499-40-5) are Granules.
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