-
Name
PROTOVERATRINE A
- EINECS 205-602-9
- CAS No. 143-57-7
- Density 1.36 g/cm3
- Solubility
- Melting Point 267-269°C
- Formula C41H63 N O14
- Boiling Point 810.6 °C at 760 mmHg
- Molecular Weight 793.95
- Flash Point 444 °C
- Transport Information UN 1544 6
- Appearance
- Safety 22-36/37/39-45
- Risk Codes 26/27/28
-
Molecular Structure
-
Hazard Symbols
T+
- Synonyms Cevane-3,4,6,7,14,15,16,20-octol,4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate)15-(2-methylbutanoate), [3b(S),4a,6a,7a,15a(R),16b]-; Cevane-3b,4b,6a,7a,14,15a,16b,20-octol, 4,9-epoxy-,6,7-diacetate 3-((+)-2-hydroxy-2-methylbutyrate) 15-((-)-2-methylbutyrate)(8CI); Protoverine, 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate)15-(2-methylbutyrate) (6CI);2H-4,16a-Epoxybenzo[7,8]fluoreno[2,1-b]quinolizine,cevane-3,4,6,7,14,15,16,20-octol deriv.; NSC 23865; NSC 7526; Protalba;Protoveratrin; Protoveratrine; Protoveratrine A; Protoverine3-[(+)-(2S)-2-hydroxy-2-methylbutyrate] 6,7-diacetate15-[(-)-(2R)-2-methylbutyrate]
- PSA 218.82000
- LogP 1.54510
PROTOVERATRINE A Chemical Properties
MF: C41H63NO14
MW: 793.94
EINECS: 205-602-9
PROTOVERATRINE A,it's melting point is about 267-269°C.
Following is the molecular structure about it:
MW: 793.94
EINECS: 205-602-9
PROTOVERATRINE A,it's melting point is about 267-269°C.
Following is the molecular structure about it:
PROTOVERATRINE A Uses
about Protoveratrine: Mixtures of closely related hypotensive alkaloids from Veratrum album (Liliaceae). They have been used in the treatment of hypertension but have largely been replaced by drugs with fewer adverse effects.
PROTOVERATRINE A Toxicity Data With Reference
RTECS FL5750100
| 1. | orl-rat LD50:5 mg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 189 (1938),397. | ||
| 2. | scu-rat LD50:480 μg/kg | APFRAD Annales Pharmaceutiques Francaises. 14 (1956),783. | ||
| 3. | ipr-mus LD50:370 μg/kg | PSEBAA Proceedings of the Society for Experimental Biology and Medicine. 76 (1951),847. | ||
| 4. | scu-mus LD50:290 μg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 113 (1955),89. | ||
| 5. | ivn-mus LD50:31 μg/kg | CKFRAY Ceskoslovenska Farmacie. 10 (1961),413. | ||
| 6. | scu-dog LDLo:500 μg/kg | AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440. | ||
| 7. | scu-cat LDLo:500 μg/kg | AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440. | ||
| 8. | scu-rbt LDLo:250 μg/kg | APFRAD Annales Pharmaceutiques Francaises. 14 (1956),783. | ||
| 9. | ivn-rbt LDLo:50 μg/kg | AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. 29 (1892),440. | ||
| 10. | scu-frg LD50:4500 μg/kg | AEPPAE Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 189 |
PROTOVERATRINE A Safety Profile
Safety Information about PROTOVERATRINE A:
Hazard Codes : T+
Risk Statements 26/27/28
Safety Statements 22-36/37/39-45
RIDADR UN 1544 6.1/PG 1
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.
Hazard Codes : T+
Risk Statements 26/27/28
Safety Statements 22-36/37/39-45
RIDADR UN 1544 6.1/PG 1
Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Protoveratrine is found to produce a striking fall in blood pressure in both essential and renal hypertension after intravenous administration.
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