-
Name
10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine
- EINECS
- CAS No. 84-97-9
- Article Data15
- CAS DataBase
- Density 1.149g/cm3
- Solubility
- Melting Point 51-53oC
- Formula C20H25 N3 S
- Boiling Point 493.6°C at 760 mmHg
- Molecular Weight 339.505
- Flash Point 252.3°C
- Transport Information
- Appearance
- Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human toxic effects by unspecified route. When heated to decomposition it emits very toxic fumes of NOx and SOx.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]- (6CI,7CI,8CI);10-(3-Methylpiperazinopropyl)phenothiazine; 10-(g-Methylpiperazinopropyl)phenothiazine;10-[3-(1-Methylpiperazin-4-yl)propyl]phenothiazine;10-[3-(4-Methyl-1-piperazinyl)propyl]phenothiazine;10-[3-(4-Methylpiperazinyl)propyl]phenothiazine; NSC 638694; P 725; Perazine;Pernazine; Psytomin; Taxilan
- PSA 35.02000
- LogP 3.86760
Pernazine Chemical Properties
Chemistry informtion about Pernazine (CAS NO.84-97-9) is:
IUPAC Name: 10-[3-(4-Methylpiperazin-1-Yl)Propyl]Phenothiazine
Synonyms: 10-[3-(4-Methyl-1-Piperazinyl)Propyl]-10h-Phenothiazine ; Perazine ; 10-[3-[4-Methyl-1-Piperazinyl] Propyl] Phenothiazine ; 10h-Phenothiazine, 10-(3-(4-Methyl-1-Piperazinyl)Propyl)-, (Z)-2-Buten Edioate (1:2) ; 10-[3-(4-Methylpiperazinyl)Propyl]Phenothiazine ; Nsc 638694 ; P 725 ; Pernazine
Product Categories: Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds
MF: C20H25N3S
MW: 339.4976
EINECS: 201-578-9
Density: 1.149 g/cm3
Melting Point: 51-53°C
Flash Point: 252.3 °C
Boiling Point: 493.6 °C at 760 mmHg
Vapour Pressure: 6.91E-10 mmHg at 25°C
Enthalpy of Vaporization: 76.08 kJ/mol
Following is the molecular structure of Pernazine (CAS NO.84-97-9) is:
Pernazine Uses
Pernazine (CAS NO.84-97-9) was used as Antipsychotic.
Pernazine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | unreported | 270mg/kg/28D (270mg/kg) | behavioral: somnolence (general depressed activity) behavioral: ataxia | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 911, 1982. |
| mouse | LD50 | intraperitoneal | 185mg/kg (185mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| mouse | LD50 | intravenous | 75mg/kg (75mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| mouse | LD50 | oral | 640mg/kg (640mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| mouse | LD50 | subcutaneous | 560mg/kg (560mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| rabbit | LD50 | intravenous | 25mg/kg (25mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| rat | LD50 | intraperitoneal | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| rat | LD50 | intravenous | 80mg/kg (80mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 199, 1958. | |
| rat | LD50 | oral | 500mg/kg (500mg/kg) | behavioral: convulsions or effect on seizure threshold | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 115, Pg. 1, 1958. |
Pernazine Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. Human toxic effects by unspecified route. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Pernazine Specification
Pernazine (CAS NO.84-97-9) is a crystalline solid.
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