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Name
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one
- EINECS 200-835-2
- CAS No. 51753-57-2
- Article Data3
- CAS DataBase
- Density 1.61 g/cm3
- Solubility soluble in water and ether, micro-soluble in 95% ethanol, dissolved in chloroform. 0.1 grams of samples dissolved in 5 ml chloroform
- Melting Point 225-230oC
- Formula C15H10BrClN2O
- Boiling Point 493 °C at 760 mmHg
- Molecular Weight 349.614
- Flash Point 251.9 °C
- Transport Information
- Appearance White or off-white crystalline powder
- Safety 16-36/37
- Risk Codes 11-20/21/22-36
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Molecular Structure
- Hazard Symbols F,Xn
- Synonyms 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrobenzo[e]-1,4-diazepin-2-one;BD 98;Fenazepam;
- PSA
- LogP
Phenazepam Chemical Properties
IUPAC Name: 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
Synonyms of Phenazepam (CAS NO.51753-57-2): 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-chlorophenyl)- ; Fenazepam ; Phenazepam
CAS NO: 51753-57-2
Molecular Formula: C15H10BrClN2O
Molecular Weight: 349.609
Molecular Structure: 
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 1
Polar Surface Area: 32.67 Å2
Index of Refraction: 1.691
Molar Refractivity: 83.14 cm3
Molar Volume: 217.1 cm3
Surface Tension: 53.2 dyne/cm
Density: 1.61 g/cm3
Flash Point: 251.9 °C
Enthalpy of Vaporization: 76 kJ/mol
Boiling Point: 493 °C at 760 mmHg
Vapour Pressure: 7.32E-10 mmHg at 25°C
SMILES: Clc3ccccc3C/2=N/CC(=O)Nc1c\2cc(Br)cc1
InChI: InChI=1/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
InChIKey: CGMJQQJSWIRRRL-UHFFFAOYAF
Std. InChI: InChI=1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
Std. InChIKey: CGMJQQJSWIRRRL-UHFFFAOYSA-N
Product Categories of Phenazepam (CAS NO.51753-57-2): Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Phenazepam Uses
Phenazepam is a benzodiazepine drug, which is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal syndrome and insomnia. Besides, Phenazepam can be still used as a premedication before surgery as it enhance the effects of anesthetics and reduces anxiety.
Phenazepam Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 620mg/kg (620mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 13(10), Pg. 108, 1979. | |
| mouse | LD50 | oral | 2400mg/kg (2400mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 13(10), Pg. 108, 1979. | |
| rat | LD50 | intraperitoneal | 720mg/kg (720mg/kg) | Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 13(10), Pg. 108, 1979. |
Phenazepam Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl−, Br−, and NOx.
Phenazepam Specification
Side effects of Phenazepam (CAS NO.51753-57-2):
Phenazepam cause such side effects as follows: dizziness, loss of coordination and drowsiness, along with anterograde amnesia which can be quite pronounced at high doses. As with other benzodiazepines, in case of abrupt discontinuation following prolonged use, severe withdrawal symptoms may occur, such as restlessness, anxiety, insomnia and convulsions.
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