Product Name

  • Name

    Phenformin

  • EINECS 204-057-4
  • CAS No. 114-86-3
  • Article Data10
  • CAS DataBase
  • Density 1.24 g/cm3
  • Solubility
  • Melting Point 280-282°C
  • Formula C10H15N5
  • Boiling Point 413.7 °C at 760 mmHg
  • Molecular Weight 205.263
  • Flash Point 204 °C
  • Transport Information
  • Appearance white powder
  • Safety 36
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 114-86-3 (Phenformin)
  • Hazard Symbols HarmfulXn
  • Synonyms Biguanide,1-phenethyl- (6CI,8CI);(Phenylethyl)biguanide;1-Phenethylbiguanide;Cronoformin;Debeone;Diabis;Dibiraf;Dibotin;Fenfoduron;Fenformin;Fenormin;Glukopostin;Glyphen;Phenethylbiguanide;
  • PSA 97.78000
  • LogP 2.72010

Phenformin Chemical Properties

Molecular Structure of Phenformin (CAS NO.114-86-3):

IUPAC Name: 1-(diaminomethylidene)-2-phenethylguanidine
Empirical Formula: C10H15N5
Molecular Weight: 205.2596
EINECS: 204-057-4
H bond acceptors: 5
H bond donors: 6
Freely Rotating Bonds: 4
Polar Surface Area: 34.44 Å2
Index of Refraction: 1.62
Molar Refractivity: 57.93 cm3
Molar Volume: 164.8 cm3
Surface Tension: 53.8 dyne/cm
Density: 1.24 g/cm3
Flash Point: 204 °C
Enthalpy of Vaporization: 66.65 kJ/mol
Boiling Point: 413.7 °C at 760 mmHg
Vapour Pressure: 4.71E-07 mmHg at 25°C
Classification Code: Drug / Therapeutic Agent; Hypoglycemic agents; Tumor data
InChI
InChI=1/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
Smiles
c1(CCNC(NC(N)=N)=N)ccccc1

Phenformin Production

 It derived from phenylethylamine hydrochloride and dicyandiamide by heating at 142 °C, responsed by post-processing.

Phenformin Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 subcutaneous 16mg/kg (16mg/kg)   Medicina Experimentalis. Vol. 8, Pg. 237, 1963.
guinea pig LDLo intravenous 30mg/kg (30mg/kg)   "Hemoperfusion: Kidney and Liver Support and Detoxification, Proceedings of the International Symposium, Haifa, 1979," Sideman, S., and T.M.S. Chang, eds., Multiple parts, New York, Hemisphere Pub. Corp., 1980-Vol. 1, Pg. 337, 1980.
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   Bollettino Chimico Farmaceutico. Vol. 97, Pg. 396, 1958.
mouse LD50 oral 450mg/kg (450mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 236, 1985.
rat LD50 oral 650mg/kg (650mg/kg)   Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 236, 1985.

Phenformin Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.Safety information of Phenformin (CAS NO.114-86-3):
Hazard Codes: HarmfulXn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DU2200000

Phenformin Specification

 Phenformin , with CAS number of 114-86-3, can be called Phenethvdiguanide ; N′-β-Phenethylformamidin-ylliminourea ; N′-β-Fenetilformamidiniliminourea (italian) ; β-Phenethylbiguanide ; Phenformin Hydrochloride ; Phenformine [INN-French] ; Phenforminum [INN-Latin] ; Fenformina . Phenformin (CAS NO.114-86-3) is hypoglycemic agents, applicable to all types of diabetes. Can be made into a variety of products such as glass cloth laminated board, mold plastic film, adhesives, insulating paint, foam and fiber.

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