-
Name
Pheniodol
- EINECS
- CAS No. 577-91-3
- Density 2.081g/cm3
- Solubility
- Melting Point 164°C
- Formula C15H12I2O3
- Boiling Point 439°C at 760 mmHg
- Molecular Weight 494.067
- Flash Point 219.3°C
- Transport Information
- Appearance
- Safety Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of I−.
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Biliselectan;2-Phenyl-3-(3,5-dijod-4-hydroxy-phenyl)-propionsaeure;Biliselktan;Jodobil;3-(4-Hydroxy-3,5-dijod-phenyl)-2-phenyl-propionsaeure;3-(4-Hydroxy-3,5-diiodo-phenyl)-2-phenyl-propanoic acid;Pheniodol;Biselectan;3-(4-hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic acid;Coletrast;Bilitrast;Biliognost;3-(3.5-Dijod-4-hydroxy-phenyl)-2-phenyl-propionsaeure;Benzenepropanoic acid, 4-hydroxy-3,5-diiodo-α-phenyl-;Iodoalphionic acid;Iodobil;
- PSA 57.53000
- LogP 4.01230
Pheniodol Chemical Properties
IUPAC Name: 3-(4-Hydroxy-3,5-diiodophenyl)-2-phenylpropanoic acid
Synonyms of Pheniodol (CAS NO.577-91-3) : 3-(4-Hydroxy-3,5-diiodophenyl)-2-phenylpropanoic acid ; 3,5-Diiodo-a-phenylphloretic Acid ; 4-Hydroxy-3,5-diiodo-a-phenylbenzenepropanoic Acid ; b-(4-Hydroxy-3,5-diiodophenyl)-a-phenylpropionic Acid ; Benzenepropanoic acid, 4-hydroxy-3,5-diiodo-alpha-phenyl-
CAS NO: 577-91-3
Molecular Formula:C15H12I2O3
Molecular Weight :494.0629
Molecular Structure :.png)
Index of Refraction: 1.724
Surface Tension: 68.2 dyne/cm
Density: 2.081 g/cm3
Flash Point: 219.3 °C
Enthalpy of Vaporization: 73.34 kJ/mol
Boiling Point: 439 °C at 760 mmHg
Vapour Pressure: 1.76E-08 mmHg at 25°C
Appearance: Pheniodol (CAS NO.577-91-3) is white or milky white crystalline powder with slightly smelly, and irritating odor.
Solubility: Insoluble in water, soluble in ethanol or ether, slightly soluble in chloroform, soluble in alkaline aqueous solution.
Pheniodol Uses
Pheniodol (CAS NO.577-91-3) is used as oral cholecystography agents.
Pheniodol Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intravenous | 100mg/kg (100mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Laboratory and Clinical Medicine. Vol. 27, Pg. 1376, 1942. |
| cat | LDLo | oral | 500mg/kg (500mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: NAUSEA OR VOMITING | Journal of Laboratory and Clinical Medicine. Vol. 27, Pg. 1376, 1942. |
| guinea pig | LD50 | intraperitoneal | 930mg/kg (930mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ANTIPSYCHOTIC LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953. |
| mouse | LD50 | intraperitoneal | 640mg/kg (640mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ANTIPSYCHOTIC LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953. |
| mouse | LD50 | intravenous | 400mg/kg (400mg/kg) | Journal of Medicinal Chemistry. Vol. 13, Pg. 997, 1970. | |
| mouse | LD50 | oral | 2950mg/kg (2950mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ANTIPSYCHOTIC LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953. |
| rat | LD50 | intraperitoneal | 510mg/kg (510mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ANTIPSYCHOTIC LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953. |
| rat | LD50 | intravenous | 390mg/kg (390mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Klinische Wochenscrift. Vol. 20, Pg. 125, 1941. |
| rat | LD50 | oral | 1100mg/kg (1100mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Klinische Wochenscrift. Vol. 20, Pg. 125, 1941. |
| rat | LD50 | subcutaneous | 540mg/kg (540mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Klinische Wochenscrift. Vol. 20, Pg. 125, 1941. |
Pheniodol Safety Profile
Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When Pheniodol (CAS NO.577-91-3) is heated to decomposition, it emits very toxic fumes of I−.
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