• Name

  Pheniramine maleate

• EINECS 205-051-4
• CAS No. 132-20-7
• Article Data1
• CAS DataBase
• Density 1.2233 (rough estimate)
• Solubility >=1 g/100 mL at 24 °C in water
• Melting Point 104-108 °C
• Formula C₁₆H₂₀N₂^.C₄H₄O₄
• Boiling Point 348.3 °C at 760 mmHg
• Molecular Weight 356.422
• Flash Point 164.5 °C
• Transport Information
• Appearance white powder
• Safety 36
• Risk Codes 22
• Molecular Structure
• Hazard Symbols Xn
• Synonyms dimethyl-[3-phenyl-3-(1H-pyridin-6-yl)propyl]azanium; propanedioate;Prestwick_769;Naphcon A;2-Pyridinepropanamine,N,N-dimethyl-?- phenyl-,(2Z)-2-butenedioate (1:1);but-2-enedioic acid; N,N-dimethyl-3-phenyl-3-pyridin-2-yl-propan-1-amine;Pheniramine maleate (JAN/USP);
• PSA 90.73000
• LogP 2.87700

Synthetic route

86-21-5

pheniramine

110-16-7

maleic acid

132-20-7

pheniramine maleate

Conditions

Conditions	Yield
In ethanol at 20℃; Solvent;	5.1 g

4463-42-7

benzyl boronic acid

132-20-7

pheniramine maleate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; tetrahydrofuran; water / 3 h / 75 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C 3: ethanol / 20 °C View Scheme

109-04-6

2-bromo-pyridine

132-20-7

pheniramine maleate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; tetrahydrofuran; water / 3 h / 75 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C 3: ethanol / 20 °C View Scheme

potassium pentacyanonitrosylchromate(III) monohydrate

132-20-7

pheniramine maleate

{Cr(NO)(CN)2(pheniramine maleate)2(H2O)}

Conditions

Conditions	Yield
With CH3COOH In acetic acid byproducts: CH3COOK, H2O, HCN; aq. acetic acid; 20-30 min, 80°C; CO2 bubbled (few h) to remove HCN; ppt. washed (H2O repeatedly; ethanol); dried (vac., over silica gel, room temp., to const. wt.); elem.anal.;	59%

tetracyanodinitrosylmolybdate(0)

132-20-7

pheniramine maleate

Mo(NO)2(CN)2(C5H4NCH(CH2CH2N(CH3)2)C6H5)2*2(HCCOOH)2*2H2O=(Mo(NO)2(CN)2(C16H20N2)2)*((HCCOOH)2)2*2H2O

Conditions

Conditions	Yield
In water; acetic acid addn. of ligand in a mixt. of water/acetic acid to a filtered aq. soln. of molybdate with shaking, refluxing for 4-5 h over a hot plate at 80°C; filtn. by suction, washing several times with dilute acetic acid, finally with water, drying in vacuo at room temp. to a constant weight, elem. anal.;	53%

pentaisothiocyanatonitrosylchromate(I)

132-20-7

pheniramine maleate

Cr(NO)(NCS)2(C16H20N2)2(H2O)*2C4H4O4

Conditions

Conditions	Yield
In acetic acid aq. acetic acid; shaking, reflux (80°C, 1-2 h), ice cooling, pptn.; filtration, washing (CH3COOH(aq.), water), drying (vac., room temp.); elem. anal.;	45%

tetracyanonitrosylchromate(I) anion

7732-18-5

water

132-20-7

pheniramine maleate

[Cr(NO)(CN)2(C5H4N(C6H5)CHCH2CH2N(CH3)2)(H2O)]*HOOCCHCHCOOH

Conditions

Conditions	Yield
In water; acetic acid adding aq.-AcOH soln. of ligand to aq. soln. of Cr complex with shaking,refluxing for 30-45 min at 80°C; filtering ppt. by suction, washing with dild. AcOH and water, drying in vacuo; elem. anal.;	42%

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Pheniramine maleate Chemical Properties

Pheniramine maleate Uses

Pheniramine maleate Production

Pheniramine maleate Toxicity Data With Reference

Pheniramine maleate Consensus Reports

Pheniramine maleate Safety Profile