Phorbol myristate acetate supplier

Name
PHORBOL 12-MYRISTATE 13-ACETATE
EINECS 16561-29-8
CAS No. 16561-29-8
Article Data1
CAS DataBase
Density 1.17 g/cm³
Solubility Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.
Melting Point
Formula C36H56 O8
Boiling Point 698.1 °C at 760 mmHg
Molecular Weight 616.836
Flash Point 208.1 °C
Transport Information
Appearance White to off-white solid.
Safety 36/37
Risk Codes 38
Molecular Structure
Hazard Symbols Xi
Synonyms Myristicacid, 9-ester with 1,1aa,1bb,4,4a,7aa,7b,8,9,9a-decahydro-4ab,7ba,9b,9aa-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8a-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one9a-acetate, (+)- (8CI); Tetradecanoic acid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester, [1aR-(1aa,1bb,4ab,7aa,7ba,8a,9b,9aa)]-;1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.;12-O-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-acetate;12-Tetradecanoylphorbol 13-monoacetate; 13-O-Acetylphorbol 12-myristate; 4b-Phorbol 12-myristate 13-acetate;Factor A1; Factor A1 (croton oil); NSC 262244; PMA; PMA (tumor promoter);Phorbol 12-myristate 13-acetate; Phorbol 12-tetradecanoate 13-acetate; Phorbolmyristate acetate; TPA; TPA (phorbol derivative); b-Phorbol 12-myristate 13-acetate
PSA 130.36000
LogP 5.75290

Phorbol myristate acetate Chemical Properties

Systematic Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate
Molecular Formula: C₃₆H₅₆O₈
Molecular Weight: 616.83 g/mol
Classification Code: Carcinogens; Mutation data; Noxae; Reproductive Effect; Skin / Eye Irritant; Tumor data
storage temperature: -20 °C
Index of Refraction: 1.553
Molar Refractivity: 168.29 cm³
Molar Volume: 525.6 cm³
Surface Tension: 50.9 dyne/cm
Density: 1.17 g/cm³
Flash Point: 208.1 °C
Enthalpy of Vaporization: 116.86 kJ/mol
Boiling Point: 698.1 °C at 760 mmHg
solubility: DMSO: DMSO solutions can be stored dark at −20?#x00b0;C for at least six months.soluble
Vapour Pressure of Phorbol myristate acetate (CAS NO.16561-29-8): 1.55E-22 mmHg at 25 °C

Phorbol myristate acetate Uses

Phorbol myristate acetate (CAS NO.16561-29-8) has a specific use in cancer diagnostics as a B-cell specific mitogen in cytogenetic testing. To view the chromosomes, a cytogenetic test requires dividing cells. It is used to stimulate division of B-cells during cytogenetic diagnosis of B-cell cancers such as chronic lymphocytic leukemia.

Phorbol myristate acetate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
domestic animals - goat/sheep	LDLo	intravenous	40ug/kg (0.04mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT BLOOD: CHANGES IN PLATELET COUNT	Journal of Applied Physiology. Vol. 54, Pg. 267, 1983.
mouse	LD	intraperitoneal	> 1mg/kg (1mg/kg)		Toxicon. Vol. 38, Pg. 123, 2000.
mouse	LD50	intravenous	309ug/kg (0.309mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Agents and Actions, A Swiss Journal of Pharmacology. Vol. 16, Pg. 535, 1985.

Phorbol myristate acetate Consensus Reports

EPA Genetic Toxicology Program.

Phorbol myristate acetate Safety Profile

Deadly poison by intravenous route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A skin irritant. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: Xi
Risk Statements: 38
R38:Irritating to skin.
Safety Statements: 36/37
S36/37:Wear suitable protective clothing and gloves.
RIDADR: 2928
WGK Germany: 3
RTECS: QH4377000
HazardClass: 6.1(a)
PackingGroup of Phorbol myristate acetate (CAS NO.16561-29-8): II

Phorbol myristate acetate Analytical Methods

Tested for stimulation of interleukin production in Jurkat cells.

Phorbol myristate acetate Specification

Phorbol myristate acetate (CAS NO.16561-29-8), its Synonyms are Tetradecanoylphorbol acetate ; 12-O-Tetradecanoyl phorbol acetate ; 12-O-Tetradecanoylphorbol 13-acetate ; 12-O-Tetradecanoylphorbol-13-acetate ; 13-O-Acetylphorbol 12-myristate ; 13-Tetradecanoylphorbol acetate ; 4beta-Phorbol 12-myristate 13-acetate . It is white to off-white solid.

Product Name

PHORBOL 12-MYRISTATE 13-ACETATE