Product Name

  • Name

    Pilsicainide hydrochloride

  • EINECS
  • CAS No. 88069-49-2
  • Article Data2
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 212-214°
  • Formula C17H24N2O.HCl
  • Boiling Point 416.9 °C at 760 mmHg
  • Molecular Weight 308.851
  • Flash Point 205.9 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 88069-49-2 (Pilsicainide hydrochloride)
  • Hazard Symbols
  • Synonyms 1H-Pyrrolizine-7a(5H)-acetamide,N-(2,6-dimethylphenyl)tetrahydro-, monohydrochloride (9CI);Pilsicainidehydrochloride;Alisrythm;Sunrythm;Pilsicainide Hydrochloride and intermediates;Pilsicainidehydrochloride(forresearchonly);pilsicaininide;n-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide hydrochloride;
  • PSA 32.34000
  • LogP 3.27130

Pilsicainide hydrochloride Chemical Properties

Product Name: Pilsicainide hydrochloride (88069-49-2)
IUPAC Name: N-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide hydrochloride
Following is the molecular structure of Pilsicainide hydrochloride (88069-49-2):

Molecular Formula: C17H24N2O.HCl
Molecular Weight: 308.85
ACD/LogP: 3.05
of Rule of 5 Violations: 0
ACD/LogD (pH 5.5): 0
ACD/LogD (pH 7.4): 1
ACD/BCF (pH 5.5): 1
ACD/BCF (pH 7.4): 1
ACD/KOC (pH 5.5): 1
ACD/KOC (pH 7.4): 3
H bond acceptors: 3
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 23.55 Å2
Flash Point: 205.9 °C
Enthalpy of Vaporization: 67.02 kJ/mol
Boiling Point: 416.9 °C at 760 mmHg
Vapour Pressure: 3.7E-07 mmHg at 25°C 
 InChI
InChI=1/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
Smiles
C1CN2CCCC2(C1)CC(Nc1c(cccc1C)C)=O.Cl
Classification Code: Anti-Arrhythmia Agents; Cardiovascular Agents; Drug / Therapeutic Agent; Membrane Transport Modulators; Sodium Channel Blockers

Pilsicainide hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 18mg/kg (18mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 461, 1991.
dog LD50 oral 50mg/kg (50mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
mouse LD50 intraperitoneal 85mg/kg (85mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse LD50 oral 175mg/kg (175mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
mouse LD50 subcutaneous 410mg/kg (410mg/kg)   Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit LD50 oral 87mg/kg (87mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1398, 1988.
rat LD50 intraperitoneal 105mg/kg (105mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
rat LD50 intravenous 18mg/kg (18mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.
rat LD50 oral 255mg/kg (255mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 457, 1991.

Pilsicainide hydrochloride Safety Profile

Safety of Pilsicainide hydrochloride (CAS NO.88069-49-2): A poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx, HCl, and Cl−.

Pilsicainide hydrochloride Specification

  Pilsicainide hydrochloride , with CAS number of 88069-49-2, can be called n-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide hydrochloride ; Pilsicainide hydrochloride ; pilsicainide hydrochloride hemihydrate ; pilsicaininide ; Pilsicainide hydrochoride ; Pilsicainidehydrochloride(forresearchonly) ; Pilsicainide Hydrochloride and intermediates ; Alisrythm .

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