Product Name

  • Name

    piperocaine

  • EINECS
  • CAS No. 32248-37-6
  • Density g/cm3
  • Solubility
  • Melting Point
  • Formula C16H23NO2
  • Boiling Point 372.3°Cat760mmHg
  • Molecular Weight 261.40
  • Flash Point 127.6°C
  • Transport Information
  • Appearance
  • Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 32248-37-6 (piperocaine)
  • Hazard Symbols 3
  • Synonyms Benzoic acid 3-(2-methylpiperidino)propyl ester;1-Piperidinepropanol, 2-methyl-, benzoate (ester);Einecs 205-262-1;Isocaine base;Metycaine;Neothesin;Piperocaina;Piperocaina [dcit]
  • PSA
  • LogP

Piperocaine Chemical Properties

Product Name: Piperocaine (CAS NO.32248-37-6)


Molecular Formula: C16H23NO2
Molecular Weight: 261.40g/mol
Mol File: 32248-37-6.mol
Boiling point: 372.3 °C at 760 mmHg
Flash Point: 127.6 °C
Density: 1.029 g/cm3
Surface Tension: 36.6 dyne/cm
Enthalpy of Vaporization: 61.94 kJ/mol
Vapour Pressure: 9.71E-06 mmHg at 25°C
XLogP3-AA: 3.4
H-Bond Donor: 0
H-Bond Acceptor: 3
Structure Descriptors of Piperocaine (CAS NO.32248-37-6):
  IUPAC Name: 3-(2-methylpiperidin-1-yl)propyl benzoate
  Canonical SMILES: CC1CCCCN1CCCOC(=O)C2=CC=CC=C2
  InChI: InChI=1S/C16H23NO2/c1-14-8-5-6-11-17(14)12-7-13-19-16(18)15-9-3-2-4-10-15/h2-4,9-10,14H,5-8,11-13H2,1H3 
  InChIKey: YQKAVWCGQQXBGW-UHFFFAOYSA-N

Piperocaine Uses

Piperocaine is a local anesthetic drug used as its hydrochloride salt for infiltration and nerve blocks.

Piperocaine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo intraspinal 50mg/kg (50mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 45, Pg. 291, 1932.
guinea pig LDLo subcutaneous 268mg/kg (268mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC Anesthesiology. Vol. 1, Pg. 305, 1940.
mouse LD50 intraperitoneal 600mg/kg (600mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 13, Pg. 27, 1956.
mouse LDLo intravenous 26400ug/kg (26.4mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 4, 1950.
mouse LDLo subcutaneous 590mg/kg (590mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 4, 1950.
rabbit LD50 intravenous 18mg/kg (18mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 106, Pg. 37, 1952.
rabbit LDLo intraspinal 9500ug/kg (9.5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 137, 1935.
rat LDLo intravenous 17500ug/kg (17.5mg/kg)   Physiological Reviews. Vol. 12, Pg. 190, 1932.

Piperocaine Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.

Piperocaine Specification

 Piperocaine ,its CAS NO. is 32248-37-6,the synonyms is (2-Methylpiperidino)propyl benzoate ; 2-Methyl-1-piperidinopropanol, benzoate ; 3-Benzoxy-1-(2-methylpiperidino)propane ; 5-20-04-00079 (Beilstein Handbook Reference) ; BRN 0012274 ; Benzoyl-gamma-(2-methylpiperidino)propanol ; Isocaine (iso-sol. Co.) base ; Metycaine ; Neothesin ; gamma-(2-Methylpiperidyl)propyl benzoate ; 1-Piperidinepropanol, 2-methyl-, benzoate(ester) .

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