Product Name

  • Name

    Potassium bis(trimethylsilyl)amide

  • EINECS 424-100-2
  • CAS No. 40949-94-8
  • Article Data9
  • CAS DataBase
  • Density 0.877 g/cm3
  • Solubility Reacts with water.
  • Melting Point 194-195°C
  • Formula C6H19KNSi2
  • Boiling Point 126 °C at 760 mmHg
  • Molecular Weight 199.485
  • Flash Point 30 °C
  • Transport Information UN 3263 8/PG 3
  • Appearance Colorless to amber solution
  • Safety 26-36/37/39-45-62-43-46-16
  • Risk Codes 14-34-67-65-63-48/20-11
  • Molecular Structure Molecular Structure of 40949-94-8 (Potassium bis(trimethylsilyl)amide)
  • Hazard Symbols CorrosiveC, FlammableF
  • Synonyms Potassium,[bis(trimethylsilyl)amino]- (7CI);Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-,potassium salt (9CI);Hexamethyldisilazane potassium salt;KHMDS;N,N-Bis(trimethylsilyl)amine potassium salt;Potassiumbis(trimethylsilyl)amide;Potassium hexamethyldisilazamide;Potassiumhexamethyldisilazane;Potassium hexamethyldisilazide;Potassiumhexamethyldisilyl azide;
  • PSA 3.24000
  • LogP 2.42250

Synthetic route

lithium bis(trimethylsilyl)amide diethyl etherate

lithium bis(trimethylsilyl)amide diethyl etherate

Conditions
ConditionsYield
With potassium tert-butylate In benzene at 20℃;79%
tetrakis(trimethylsilyl)tetrazene

tetrakis(trimethylsilyl)tetrazene

potassium hexamethylsilazane
40949-94-8

potassium hexamethylsilazane

Conditions
ConditionsYield
With potassium In diethyl ether at 25℃; for 1h;100 % Spectr.
1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

potassium hexamethylsilazane
40949-94-8

potassium hexamethylsilazane

Conditions
ConditionsYield
With potassium hydride In tetrahydrofuran for 3.25h; Irradiation;
With n-Butyl chloride In tetrahydrofuran for 0.833333h; Yield given;
With potassium hydride In diethyl ether at 20℃; for 0.5h; Inert atmosphere;
hexamethyldisilazan
72525-60-1

hexamethyldisilazan

potassium hexamethylsilazane
40949-94-8

potassium hexamethylsilazane

Conditions
ConditionsYield
With potassium hydride In tetrahydrofuran; hexane at 20℃; Inert atmosphere;
CH3C9H6NCH(CH3)2(1+)*Cl(1-)=CH3C9H6NCH(CH3)2Cl

CH3C9H6NCH(CH3)2(1+)*Cl(1-)=CH3C9H6NCH(CH3)2Cl

potassium hexamethylsilazane
40949-94-8

potassium hexamethylsilazane

C19H34N2Si2

C19H34N2Si2

Conditions
ConditionsYield
In toluene at -78 - 20℃;100%
C14H25B9N2

C14H25B9N2

potassium hexamethylsilazane
40949-94-8

potassium hexamethylsilazane

C14H24B9N2(1-)*K(1+)

C14H24B9N2(1-)*K(1+)

Conditions
ConditionsYield
In tetrahydrofuran for 0.25h;100%

Potassium bis(trimethylsilyl)amide Specification

The systematic name of Potassium bis(trimethylsilyl)amide is potassium 1,1,1,3,3,3-hexamethyldisilazan-2-ide. With the CAS registry number 40949-94-8, it is also named as potassium hexamethyldisilazanide. The product's categories are Aliphatics; Analytical Chemistry; Si (Classes of Silicon Compounds); Silazanes; Silylation (GC Derivatizing Reagents); Si-N Compounds; Trimethylsilylation (GC Derivatizing Reagents); Classes of Metal Compounds; Silicon Compounds (for Synthesis); Synthetic Organic Chemistry; Typical Metal Compounds. It is colorless to amber solution which is sensitive to moisture. And it is a strong, non-nucleophilic base with an approximate pKa of 26 (compare to lithium diisopropylamide, at 36). Additionally, this chemical should be sealed in the container and stored at the temperature of 0 °C.

The other characteristics of Potassium bis(trimethylsilyl)amide can be summarized as: (1)ACD/LogP: 2.32; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.78; (4)ACD/LogD (pH 7.4): -0.78; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 12.03 Å2; (13)Flash Point: 30 °C; (14)Enthalpy of Vaporization: 36.38 kJ/mol; (15)Boiling Point: 126 °C at 760 mmHg; (16)Vapour Pressure: 11.9 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and can cause burns, so people should keep it away from sources of ignition. And it can react violently with water. It also has possible risk of harm to the unborn child. What's more, this chemical may cause lung damage if swallowed and vapours may cause drowsiness and dizziness. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.

People can use the following data to convert to the molecule structure. 
1. SMILES:[K+].[N-]([Si](C)(C)C)[Si](C)(C)C
2. InChI:InChI=1/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1 
3. InChIKey:IUBQJLUDMLPAGT-UHFFFAOYAI

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