Chemistry informtion about Prajmalium bitartrate(CAS NO.2589-47-1) is:
Synonyms: Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21alpha)-, salt ;with (2R,3R)-2,3-dihydroxybutanedioic acid (1:1) ;Ajmalanium, 17R,21-alpha-dihydroxy-4-propyl-, hydrogen ;tartrate ;N-Propylajmalinium tartrate ;Prajmalium bitartrate
Molecular Weight: 513.64564 [g/mol]
Molecular Formula: C29H41N2O6-
H-Bond Donor: 2
H-Bond Acceptor: 7
Canonical SMILES: CCC[N+]12C3CC(C(C1O)CC)C4C2CC5(C3N(C6=CC=CC=C65)C)C4O.CC(C(C)C(=O)[O-])C(=O)[O-]
Isomeric SMILES: CCC[N+]12[C@H]3CC([C@@H]([C@H]1O)CC)C4[C@@H]2C[C@@]5([C@H]3N(C6=CC=CC=
C65)C)[C@@H]4O.C[C@H]([C@@H](C)C(=O)[O-])C(=O)[O-]
InChI: InChI=1S/C23H33N2O2.C6H10O4/c1-4-10-25-17-11-14(13(5-2)22(25)27)19-18(25)12-23(21(19)26)15-8-6-7-9-16(15)24(3)20(17)23;1-3(5(7)8)4(2)6(9)10/h6-9,13-14,17-22,26-27H,4-5,10-12H2,1-3H3;3-4H,1-2H3,(H,7,8)(H,9,10)/q+1;/p-2/t13-,14?,17-,18-,19?,20-,21+,22+,23+,25?;3-,4-/m01/s1
InChIKey: NMPJQFYJKIKRKT-GSMKOHTGSA-L
Following is the molecular structure of Prajmalium bitartrate(CAS NO.2589-47-1) is:
Prajmalium bitartrate(CAS NO.2589-47-1) was used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LDLo | intravenous | 330ug/kg (0.33mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 2085, 1972. | |
man | TDLo | oral | 1400ug/kg (1.4mg/kg) | behavioral: "hallucinations, distorted perceptions" | British Medical Journal. Vol. 2, Pg. 675, 1977. |
man | TDLo | oral | 22857ug/kg/20 (22.857mg/kg) | liver: "jaundice, cholestatic" blood: eosinophilia skin and appendages (skin): "dermatitis, other: after systemic exposure" | Postgraduate Medical Journal. Vol. 56, Pg. 738, 1980. |
mouse | LD50 | intraperitoneal | 21265ug/kg (21.265mg/kg) | United States Patent Document. Vol. #4552877, | |
mouse | LD50 | intravenous | 1700ug/kg (1.7mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 2085, 1972. | |
mouse | LD50 | oral | 33714ug/kg (33.714mg/kg) | United States Patent Document. Vol. #4552877, | |
rat | LD50 | intravenous | 3400ug/kg (3.4mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 2085, 1972. | |
rat | LD50 | oral | 54mg/kg (54mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 2085, 1972. | |
women | LDLo | oral | 22mg/kg (22mg/kg) | Archives of Toxicology. Vol. 37, Pg. 135, 1977. |
Poison by ingestion and intravenous routes. An experimental teratogen. Human systemic effects by ingestion: hallucinations and distorted perceptions. Experimental reproductive effects. An antiarrhythmic agent. When heated to decomposition it emits toxic fumes of NOx.
Prajmalium bitartrate(CAS NO.2589-47-1) is a derivative of the rauwolfia alkaloid AJMALINE. It is an anti-arrhythmia agent, but may cause liver damage.
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