Prazosin supplier | CasNO.19216-56-9

Name
Prazosin
EINECS 242-885-8
CAS No. 19216-56-9
Article Data19
CAS DataBase
Density 1.353 g/cm³
Solubility 3.2mg/L(22.5 oC)
Melting Point 278-280°C
Formula C₁₉H₂₁N₅O₄
Boiling Point 638.366 °C at 760 mmHg
Molecular Weight 383.407
Flash Point 339.871 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI);Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI);4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone;Furazosin;Lentopres;
PSA 106.95000
LogP 3.17070

Prazosin Chemical Properties

IUPAC Name: [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
The MF of Prazosin (CAS NO.19216-56-9) is C₁₉H₂₁N₅O₄.

The MW of Prazosin (CAS NO.19216-56-9) is 383.4.
Synonyms of Prazosin (CAS NO.19216-56-9): [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone ; 1-(4-Amino-6, 7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine monohydrochloride
Apperance: Crystallization
Index of Refraction: 1.651
EINECS: 242-885-8
Density: 1.352 g/ml
Flash Point: 339.9 °C
Boiling Point: 638.4 °C
Melting Point: 278-280 °C

Prazosin Uses

Prazosin (CAS NO.19216-56-9) is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity.it is a second-line choice for the treatment of high blood pressure.Prazosin is also useful in treating urinary hesitancy associated with prostatic hyperplasia by blocking alpha-1 receptors, which control constriction of both the prostate and ureters.This medication has shown to be effective in treating severe nightmares in children, associated with PTSD symptoms.

Prazosin Production

3,4-Dimethoxy--6-amino-benzonitrile generated 3,4-dimethoxy-6-Thiocyanate acyl benzonitrile in water and dichloromethane and sulfur anal phosgene (yield is 94% ).It would get thiourea derivative by reacted with 1-(2-furan-carbonyl)-piperazine in ethyl acetate(yield is 90%). Then derived free S-methyl-isothiourea derivatives by methylated with methyl iodide to the reaction with the alkali treatment(yield is 95%). Finally,formamide prazosin was gotten by the reaction of S-methyl isothiourea biological, ammonia, ammonium chloride and urea.

Prazosin Toxicity Data With Reference

1.	orl-wmn TDLo:20 µg/kg:BPR,GIT	AIMEAS Annals of Internal Medicine. 97 (1982),455.
2.	orl-man TDLo:1143 µg/kg:BPR	AMSVAZ Acta Medica Scandinavica. 213 (1983),157.
3.	orl-hmn TDLo:280 µg/kg:CNS,CVS	BMJOAE British Medical Journal. 2 (1976),508.
4.	orl-hmn TDLo:1260 µg/kg:CNS,KID	BMJOAE British Medical Journal. 1 (1978),622.

Prazosin Safety Profile

Human systemic effects by ingestion of very small amounts: somnolence, hallucinations, distorted perceptions, changes in motor activity, decreased blood pressure, nausea or vomiting, and kidney effects. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Prazosin Specification

Prazosin is a sympatholytic drug used to treat high blood pressure (hypertension). It belongs to the class of alpha-adrenergic blockers, which lower blood pressure by relaxing blood vessels. Specifically, prazosin is selective for the alpha-1 receptors on vascular smooth muscle. These receptors are responsible for the vasoconstrictive action of norepinephrine, which would normally raise blood pressure. By blocking these receptors, prazosin reduces blood pressure.

Product Name

Prazosin