Product Name

  • Name

    Prolinomethyltetracycline

  • EINECS
  • CAS No. 37106-99-3
  • Density 1.62g/cm3
  • Solubility
  • Melting Point
  • Formula C28H33 N3 O10
  • Boiling Point 814.4°Cat760mmHg
  • Molecular Weight 571.64
  • Flash Point 446.3°C
  • Transport Information
  • Appearance
  • Safety Poison by intramuscular, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 37106-99-3 (Prolinomethyltetracycline)
  • Hazard Symbols
  • Synonyms L-Proline,1-[[[[4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl]carbonyl]amino]methyl]-,[4S-(4a,4aa,5aa,6b,12aa)]-; Prolinomethyltetracycline
  • PSA 208.17000
  • LogP 0.25180

Prolinomethyltetracycline Chemical Properties

IUPAC Name: (2S)-1-[[[(E)-[(4R,4aR,5aR,6S,12aR)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-4,4a,5,5a-tetrahydrotetracen-2-ylidene]-hydroxymethyl]amino]methyl]pyrrolidine-2-carboxylic acid
Empirical Formula: C28H33N3O10
Molecular Weight: 571.5757g/mol
Index of Refraction: 1.726
Molar Refractivity: 140.37 cm3
Molar Volume: 352.8 cm3
Polarizability: 55.64×10-24cm3
Surface Tension: 98.6 dyne/cm
Density: 1.62 g/cm3
Flash Point: 446.3 °C
Enthalpy of Vaporization: 124.12 kJ/mol
Boiling Point: 814.4 °C at 760 mmHg
Vapour Pressure: 4.84E-28 mmHg at 25°C
Canonical SMILES: CC1(C2CC3C(C(=O)C(=C(NCN4CCCC4C(=O)O)O)C(=O)C3(C(=O)C2=C(C5=C1C=CC=C5O)O)O)N(C)C)O
Isomeric SMILES: C[C@@]1([C@@H]2C[C@@H]3[C@H](C(=O)/C(=C(/NCN4CCC[C@H]4C(=O)O)\O)/C(=O)
[C@@]3(C(=O)C2=C(C5=C1C=CC=C5O)O)O)N(C)C)O
InChI: InChI=1S/C28H33N3O10/c1-27(40)12-6-4-8-16(32)17(12)21(33)18-13(27)10-14-20(30(2)3)22(34)19(24(36)28(14,41)23(18)35)25(37)29-11-31-9-5-7-15(31)26(38)39/h4,6,8,13-15,20,29,32-33,37,40-41H,5,7,9-11H2,1-3H3,(H,38,39)/b25-19+/t13-,14-,15+,20-,27-,28-/m1/s1
InChIKey: SDVPUCSIJKFEHB-JHVVBUMPSA-N
Structure of Prolinomethyltetracycline (CAS NO.37106-99-3):

Prolinomethyltetracycline Toxicity Data With Reference

1.    

ipr-rat LD50:115 mg/kg

     JJANAX    Japanese Journal of Antibiotics. 25 (1972),95.
2.    

scu-rat LD50:1733 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 6 (1972),51.
3.    

ivn-rat LD50:144 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 6 (1972),51.
4.    

ims-rat LD50:788 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 6 (1972),51.
5.    

ipr-mus LD50:353 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 6 (1972),51.
6.    

scu-mus LD50:1465 mg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 6 (1972),51.
7.    

ivn-mus LD50:85,100 µg/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 6 (1972),51.
8.    

ims-mus LD50:283 mg/kg

     JJANAX    Japanese Journal of Antibiotics. 24 (1971),156.

Prolinomethyltetracycline Safety Profile

Poison by intramuscular, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

Prolinomethyltetracycline Specification

  Prolinomethyltetracycline its cas register number is 37106-99-3. It also can be called  PM-TC ; L-Proline, 1-((((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl)carbonyl)amino)methyl)-, (4S-(4-alpha,4a-alpha,5a-alpha,6-beta,12a-alpha))- . When heated to decomposition it emits toxic fumes of NOx. Wear suitable protective clothing and gloves when contact with Prolinomethyltetracycline (CAS NO.37106-99-3).

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