• Name

  Promestriene

• EINECS 254-361-6
• CAS No. 39219-28-8
• Article Data2
• CAS DataBase
• Density 1.06 g/cm³
• Solubility
• Melting Point 64-66 °C
• Formula C₂₂H₃₂O₂
• Boiling Point 436.8 °C at 760 mmHg
• Molecular Weight 328.495
• Flash Point 153.3 °C
• Transport Information
• Appearance white solid
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 3-Propoxy-17b-methoxyestra-1,3,5(10)-triene;Promestrienum;
• PSA 18.46000
• LogP 5.34650

Synthetic route

100017-39-8, 4954-12-5

17β-methoxyestra-1,3,5(10)-trien-3-ol

106-94-5

propyl bromide

39219-28-8

3-propoxy-17β-methoxyestra-1,3,5(10)-triene

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In methanol at 64℃; for 24h; Williamson Ether Synthesis;	92%

13-methyl-3-propoxy-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

74-88-4

methyl iodide

39219-28-8

3-propoxy-17β-methoxyestra-1,3,5(10)-triene

Conditions

Conditions	Yield
Stage #1: 13-methyl-3-propoxy-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol With sodium hydroxide In tetrahydrofuran for 1h; Stage #2: methyl iodide In tetrahydrofuran for 5h;	90.7%

50-28-2

estradiol

39219-28-8

3-propoxy-17β-methoxyestra-1,3,5(10)-triene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen bromide / acetone / 24 h / 55 °C / Inert atmosphere 2: methanol / 12 h / 64 °C / Inert atmosphere 3: potassium iodide; potassium carbonate / methanol / 24 h / 64 °C View Scheme

39219-28-8

3-propoxy-17β-methoxyestra-1,3,5(10)-triene

18039-42-4

5-phenyl-2H-1,2,3,4-tetrazole

C29H34N4O2

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 13h; Electrochemical reaction; Green chemistry;	46%

Promestriene Chemical Properties

Promestriene Uses

Promestriene Specification