Product Name

  • Name

    Propantheline bromide

  • EINECS 200-030-6
  • CAS No. 50-34-0
  • Density 1.2916 (rough estimate)
  • Solubility water: >=10 g/100 mL at 21 °C
  • Melting Point 159-161 °C
  • Formula C23H30NO3.Br
  • Boiling Point
  • Molecular Weight 448.4
  • Flash Point
  • Transport Information
  • Appearance white crystalline powder
  • Safety 36
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 50-34-0 (Propantheline bromide)
  • Hazard Symbols HarmfulXn
  • Synonyms Lubricant Additives T2007B Polyisobutylene Succinic Anhydride;(2-Hydroxyethyl)diisopropylmethylammoniumbromide xanthene-9-carboxylate (6CI);Ammonium, (2-hydroxyethyl)diisopropylmethyl-, bromide,xanthene-9-carboxylate (8CI);Corrigast;Ercorax;Ercotina;Kivatin;Neo-Metantyl;Neopepulsan;Pantas;Pervagal;Pro-Banthine;Pro-Gastron;Prodixamon;Propantel;SC 3171;b-Diisopropylaminoethyl xanthene-9-carboxylatemethobromide;
  • PSA 35.53000
  • LogP 1.73480

Synthetic route

methyl bromide
74-83-9

methyl bromide

xanthene-9-carboxylic acid <2-diisopropylamino-ethyl ester

xanthene-9-carboxylic acid <2-diisopropylamino-ethyl ester

propantheline bromide
50-34-0

propantheline bromide

Conditions
ConditionsYield
With chloroform
propantheline bromide
50-34-0

propantheline bromide

xanthene-9-carboxylic acid
82-07-5

xanthene-9-carboxylic acid

Conditions
ConditionsYield
With water at 100℃; for 1.16667h; pH=7.0; Kinetics; Further Variations:; pH-values;
silver(I) 4-methylbenzenesulfonate
16836-95-6

silver(I) 4-methylbenzenesulfonate

propantheline bromide
50-34-0

propantheline bromide

propantheline p-toluenesulfonate
1107608-70-7

propantheline p-toluenesulfonate

Conditions
ConditionsYield
In acetonitrile at 20℃; Darkness;

Propantheline bromide Chemical Properties

 Propantheline bromide ,its CAS register number is 50-34-0,it's called for Ammonium,diisopropyl(2-hydroxyethyl)methyl-,bromide,xanthene-9-carboxylate ; Diisopropyl(2-hydroxyethyl)methylammoniumbromidexanthene-9-carboxylate ; Ercorax ; Ercotina ; Iumbromide ; Ketaman ; Kivatin ; Nci-c56257 ; Pantheline ; Probantine ; Prodixamon ; Corrigast ,and so on. Propantheline bromide (CAS No.50-34-0) is usually white crystals or white powder.

IUPAC Name: Methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium bromide
CAS: 50-34-0
Molecular Formula: C23H30BrNO3
Molecular Weight: 448.39
Molecular structure:
EINECS: 200-030-6
Melting point:  159-161°C
Water solubility:  >=10 g/100 mL at 21 ºC
ACD/LogD (pH 5.5): -1.77 
ACD/LogD (pH 7.4): -1.77 
ACD/BCF (pH 5.5): 1 
ACD/BCF (pH 7.4): 1 
ACD/KOC (pH 5.5): 2.61 
ACD/KOC (pH 7.4): 2.61 
H bond acceptors: 4 
H bond donors: 0 

Propantheline bromide Uses

1. Propantheline bromide (CAS No.50-34-0) is mainly used as an antimuscarinic agent for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, involuntary urination (enuresis), etc.
2. Propantheline bromide (CAS No.50-34-0) is also used to control the symptoms of irritable bowel syndrome and similar conditions.

Propantheline bromide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 51mg/kg (51mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 151, Pg. 614, 1957.
mouse LD50 intraperitoneal 60mg/kg (60mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
mouse LD50 intravenous 6400ug/kg (6.4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
mouse LD50 oral 445mg/kg (445mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 319, 1970.
mouse LD50 subcutaneous 128mg/kg (128mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 326, 1969.
rabbit LD50 oral 750mg/kg (750mg/kg)   Guide to the Chemicals Used in Crop Protection. Vol. 6, Pg. 36, 1973.
rat LD50 intraduodenal 125mg/kg (125mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LD50 intraperitoneal 25mg/kg (25mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intravenous 4mg/kg (4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Toxicology and Applied Pharmacology. Vol. 1, Pg. 391, 1959.
rat LD50 oral 370mg/kg (370mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LD50 subcutaneous 298mg/kg (298mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.

RTECS:  BP8249200

Propantheline bromide Safety Profile

Hazard Codes:  Xn
Risk Statements:  22 (R22:Harmful if swallowed.)
Safety Statements:  36 (S36:Wear suitable protective clothing.)

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