Product Name

  • Name

    Propranolol hydrochloride

  • EINECS 206-268-7
  • CAS No. 318-98-9
  • Article Data16
  • CAS DataBase
  • Density
  • Solubility soluble in water
  • Melting Point 163-165 ºC (lit.)
  • Formula C16H21NO2.HCl
  • Boiling Point 434.9 ºC at 760 mmHg
  • Molecular Weight 295.809
  • Flash Point 216.8 ºC
  • Transport Information
  • Appearance off-white to light-yellow cyrstalline solid
  • Safety 22
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 318-98-9 (Propranolol hydrochloride)
  • Hazard Symbols HarmfulXn,IrritantXi
  • Synonyms 1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol hydrochloride;DL-Propranolol hydrochloride;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride;2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, hydrochloride;1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol hydrochloride;(2-Hydroxy-3-(naphthyloxy)propyl)isopropylammonium chloride;
  • PSA 41.49000
  • LogP 3.77040

Synthetic route

α-naphthol
90-15-3

α-naphthol

isopropylamine
75-31-0

isopropylamine

1,2-Epoxy-3-bromopropane
3132-64-7

1,2-Epoxy-3-bromopropane

Inderal
318-98-9

Inderal

Conditions
ConditionsYield
Stage #1: α-naphthol; isopropylamine; 1,2-Epoxy-3-bromopropane With potassium carbonate In N,N-dimethyl-formamide; acetone at 20 - 60℃; for 8h;
Stage #2: With hydrogenchloride In water at 0 - 50℃; for 2h; Temperature;		85.8%
...Expand
propranolol
525-66-6

propranolol

Inderal
318-98-9

Inderal

Conditions
ConditionsYield
Stage #1: propranolol With pyrographite In ethanol for 0.5h; Reflux;
Stage #2: With hydrogenchloride at 4℃; pH=2;		85.1%
With hydrogenchloride In ethanol; water79.7%
3-(1-naphthyloxy)-1,2-epoxypropane
2461-42-9

3-(1-naphthyloxy)-1,2-epoxypropane

isopropylamine
75-31-0

isopropylamine

Inderal
318-98-9

Inderal

Conditions
ConditionsYield
With hydrogenchloride for 16h; Heating;77%
N-(1-methylethyl)-3-(1-naphthalenyloxy)-2-nitroxypropylamine hydrochloride

N-(1-methylethyl)-3-(1-naphthalenyloxy)-2-nitroxypropylamine hydrochloride

Inderal
318-98-9

Inderal

Conditions
ConditionsYield
With phosphate buffer; L-cysteine ethyl ester hydrochloride at 37℃; for 0.25h; pH=7.7; Product distribution; Further Variations:; pH-values; reaction time;
C44H36N4O12P2(2-)*C16H21NO2*H(1+)

C44H36N4O12P2(2-)*C16H21NO2*H(1+)

A

Inderal
318-98-9

Inderal

B

C44H36N4O12P2(2-)

C44H36N4O12P2(2-)

Conditions
ConditionsYield
In d(4)-methanol; water-d2 Equilibrium constant;
α-naphthol
90-15-3

α-naphthol

Inderal
318-98-9

Inderal

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / 8 h / 35 °C
2.1: sodium tetrahydroborate / methanol / 2 h / 20 °C
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 40 °C
4.1: pyrographite / ethanol / 0.5 h / Reflux
4.2: 4 °C / pH 2
View Scheme
1-bromo-3-(1-naphthalenyloxy)-2-propanone
2007-18-3

1-bromo-3-(1-naphthalenyloxy)-2-propanone

Inderal
318-98-9

Inderal

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / methanol / 2 h / 20 °C
2.1: 5,5-dimethyl-1,3-cyclohexadiene / 4 h / 40 °C
3.1: pyrographite / ethanol / 0.5 h / Reflux
3.2: 4 °C / pH 2
View Scheme
Inderal
318-98-9

Inderal

cyclohexanylcarbonyl chloride
2719-27-9

cyclohexanylcarbonyl chloride

O-cyclohexanoylpropranolol hydrochloride

O-cyclohexanoylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;97%
Inderal
318-98-9

Inderal

acetyl chloride
75-36-5

acetyl chloride

O-acetylpropranolol hydrochloride
4290-58-8

O-acetylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;93%
pivaloyl chloride
3282-30-2

pivaloyl chloride

Inderal
318-98-9

Inderal

O-pivaloyl-1-(1-naphthyloxy)-3-isopropylaminopropan-2-ol hydrochloride
94769-42-3

O-pivaloyl-1-(1-naphthyloxy)-3-isopropylaminopropan-2-ol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;91%
In chloroform for 15h; Heating;60%
Inderal
318-98-9

Inderal

butyryl chloride
141-75-3

butyryl chloride

(+/-)-propranolol butyrate

(+/-)-propranolol butyrate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;91%
Inderal
318-98-9

Inderal

succinic acid monomethylester chloride
1490-25-1

succinic acid monomethylester chloride

Succinic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

Succinic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;88%
methyl 4-(chlorocarbonyl)butyrate
1501-26-4

methyl 4-(chlorocarbonyl)butyrate

Inderal
318-98-9

Inderal

Pentanedioic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

Pentanedioic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;87%
acetic anhydride
108-24-7

acetic anhydride

Inderal
318-98-9

Inderal

N-[2-acetyloxy-3-(1-naphthalenyloxy)propyl]-N-(1-methylethyl)acetamide
70153-33-2

N-[2-acetyloxy-3-(1-naphthalenyloxy)propyl]-N-(1-methylethyl)acetamide

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃; for 20h;87%
Inderal
318-98-9

Inderal

isopentanoyl chloride
108-12-3

isopentanoyl chloride

O-isovalerylpropranolol hydrochloride

O-isovalerylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;85%
Inderal
318-98-9

Inderal

Cyclobutanecarbonyl chloride
5006-22-4

Cyclobutanecarbonyl chloride

Cyclobutanecarboxylic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

Cyclobutanecarboxylic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;85%
Inderal
318-98-9

Inderal

isobutyryl chloride
79-30-1

isobutyryl chloride

O-isobutyrylpropranolol hydrochloride

O-isobutyrylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;84%
Inderal
318-98-9

Inderal

butyryl chloride
141-75-3

butyryl chloride

O-Butyryl propranolol hydrochloride

O-Butyryl propranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;84%
Inderal
318-98-9

Inderal

cyclopropanecarboxylic acid chloride
4023-34-1

cyclopropanecarboxylic acid chloride

O-cyclopropanoylpropranolol hydrochloride

O-cyclopropanoylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;83%
Inderal
318-98-9

Inderal

N-nitrosopropranolol
84418-35-9

N-nitrosopropranolol

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite at 50℃; for 2h;82%
With acetate buffer; sodium nitrite In water at 95℃; for 3h;77%
1-bromo-2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethane
854601-80-2

1-bromo-2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethane

Inderal
318-98-9

Inderal

C27H43NO7

C27H43NO7

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 45℃; for 20h;81%
Inderal
318-98-9

Inderal

chloropropranolol
47054-95-5

chloropropranolol

Conditions
ConditionsYield
With N-chloro-succinimide; dimethyl sulfoxide In chloroform at 25℃; for 12h; Reagent/catalyst; Schlenk technique;79%
copper(II) acetate monohydrate
6046-93-1

copper(II) acetate monohydrate

Inderal
318-98-9

Inderal

[Cu2(1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol(-1H))2(OAc)2]
796073-45-5

[Cu2(1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol(-1H))2(OAc)2]

Conditions
ConditionsYield
With NaOH In methanol; water to soln. of ligand in MeOH equimolar amt. of aq. NaOH soln. added dropwise; to resulting soln. (pH 5-7) soln. of metal salt in MeOH added until the final metal ion:ligand:NaOH molar ratio was 1:2:2; mixt. stirred forfor 120 min at 40°C; ppt. filtered; washed (MeOH/H2O, 1:1 v/v); dried (vac., P4O10) for several ds; elem. anal.;70%
propionyl chloride
79-03-8

propionyl chloride

Inderal
318-98-9

Inderal

O-propionylpropranolol hydrochloride

O-propionylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;69%
Inderal
318-98-9

Inderal

22-bromo-2,5,8,11,14,17,20-heptaoxadocosane
104518-25-4

22-bromo-2,5,8,11,14,17,20-heptaoxadocosane

C31H51NO9

C31H51NO9

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 45℃; for 22h;69%
2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)acetic acid
101791-31-5

2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)acetic acid

Inderal
318-98-9

Inderal

C33H53NO11
1058180-03-2

C33H53NO11

Conditions
ConditionsYield
With dmap; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 20h;68%
3-chloro-3-oxopropanoic acid methyl ester
37517-81-0

3-chloro-3-oxopropanoic acid methyl ester

Inderal
318-98-9

Inderal

Malonic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

Malonic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester methyl ester; hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;67%
3,6,9-trioxadecyl bromide
72593-77-2

3,6,9-trioxadecyl bromide

Inderal
318-98-9

Inderal

C23H35NO5

C23H35NO5

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 45℃; for 22h;66%
Inderal
318-98-9

Inderal

n-valeryl chloride
638-29-9

n-valeryl chloride

O-valerylpropranolol hydrochloride

O-valerylpropranolol hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;65%
cobalt(II) chloride dihydrate

cobalt(II) chloride dihydrate

Inderal
318-98-9

Inderal

[Co(1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol(-1H))2(H2O)2]
796073-46-6

[Co(1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol(-1H))2(H2O)2]

Conditions
ConditionsYield
With NaOH In water; acetonitrile to soln. of ligand in H2O/MeCN (1/5 v/v) soln. of NaOH added dropwise; soln. of metal salt in MeCN/H2O (5/1, v/v) added; mixt. stirred for 60 min at room temp.; ppt. filtered; washed (MeCN/H2O, 1:1 v/v); dried (vac., P4O10) for several ds; elem. anal.;65%
1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane
423-39-2

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane

methyl 4-(1-((triisopropylsilyl)oxy)vinyl)benzoate
1356459-76-1

methyl 4-(1-((triisopropylsilyl)oxy)vinyl)benzoate

Inderal
318-98-9

Inderal

methyl 4-(2-(3-isopropyl-5-((naphthalen-1-yloxy)methyl)-2-(perfluoropropyl)oxazolidin-2-yl)acetyl)benzoate

methyl 4-(2-(3-isopropyl-5-((naphthalen-1-yloxy)methyl)-2-(perfluoropropyl)oxazolidin-2-yl)acetyl)benzoate

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; acriflavine In acetonitrile for 28h; Inert atmosphere;64%
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 20℃; for 28h; Inert atmosphere; Irradiation;64%
...Expand
Inderal
318-98-9

Inderal

1-{[(4-nitrophenoxy)carbonyl]oxy}ethyl acetate
101623-68-1

1-{[(4-nitrophenoxy)carbonyl]oxy}ethyl acetate

1--N-isopropylamino>-3-(1-naphthyloxy)-2-propanol
99106-37-3

1--N-isopropylamino>-3-(1-naphthyloxy)-2-propanol

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide Ambient temperature;61%
61%
Cyclopentanecarboxylic acid chloride
4524-93-0

Cyclopentanecarboxylic acid chloride

Inderal
318-98-9

Inderal

Cyclopentanecarboxylic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

Cyclopentanecarboxylic acid 1-(isopropylamino-methyl)-2-(naphthalen-1-yloxy)-ethyl ester; hydrochloride

Conditions
ConditionsYield
In chloroform for 2h; Heating;58%

Propranolol hydrochloride Specification

The Propranolol hydrochloride, with the CAS registry number 318-98-9, is also known as DL-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride. It belongs to the product categories of Aromatic Alcohols and Diols; Intermediates & Fine Chemicals; Pharmaceuticals; API's; APIs; Amines; Aromatics. Its EINECS registry number is 206-268-7. This chemical's molecular formula is C16H22ClNO2 and molecular weight is 295.8. What's more, both its IUPAC name and systematic name are the same which is called 1-Naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol hydrochloride. It is used for various functional arrhythmia, supraventricular and ventricular ectopic extrasystoles, atrial fibrillation and other arrhythmias caused by anesthesia.

Physical properties about Propranolol hydrochloride are: (1)ACD/LogP: 3.10; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.09; (4)ACD/LogD (pH 7.4): 1.27; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 1.13; (8)ACD/KOC (pH 7.4): 17.36; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 7; (12)Polar Surface Area: 21.7 Å2; (13)Flash Point: 216.8 °C; (14)Enthalpy of Vaporization: 72.84 kJ/mol; (15)Boiling Point: 434.9 °C at 760 mmHg; (16)Vapour Pressure: 2.48E-08 mmHg at 25 °C.

Preparation of Propranolol hydrochloride: this chemical can be prepared by Isopropylamine with (R)-(-)-1-Chloro-2-acetoxy-3-(1-naphthyloxy)propane. This reaction needs reagents water, NaOH at ambient temperature. The reaction time is 16 hours. The yield is 100 %.

Propranolol hydrochloride can be prepared by Isopropylamine with (R)-(-)-1-Chloro-2-acetoxy-3-(1-naphthyloxy)propane.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health and it may cause inflammation to the skin or other mucous membranes. It is harmful if swallowed. The gas can not be breathed.

You can still convert the following datas into molecular structure:
(1) SMILES: Cl.OC(CNC(C)C)COc2cccc1ccccc12
(2) InChI: InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
(3) InChIKey: ZMRUPTIKESYGQW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD oral > 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: FOOD INTAKE (ANIMAL)		 Acta Pharmacologica et Toxicologica. Vol. 26, Pg. 343, 1968.
Link to PubMed
dog LDLo intravenous 22811ug/kg (22.811mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 488, 1969.
Link to PubMed
guinea pig LDLo intravenous 28100ug/kg (28.1mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
Link to PubMed
man LDLo oral 34mg/kg (34mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Drug Intelligence and Clinical Pharmacy. Vol. 22, Pg. 781, 1988.
Link to PubMed
man TDLo intravenous 29ug/kg/5M-I (0.029mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION		 Annals of Emergency Medicine. Vol. 14, Pg. 1112, 1985.
Link to PubMed
man TDLo oral 857ug/kg/3D-I (0.857mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 121, Pg. 1326, 1985.
Link to PubMed
man TDLo oral 4mg/kg/1W-I (4mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: COUGH		 Drug Intelligence and Clinical Pharmacy. Vol. 16, Pg. 776, 1982.
Link to PubMed
man TDLo oral 43mg/kg (43mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 South African Medical Journal. Vol. 67, Pg. 1062, 1985.
man TDLo oral 417mg/kg/1Y-I (417mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION Practitioner. Vol. 229, Pg. 663, 1985.
Link to PubMed
mouse LD50 intraperitoneal 80mg/kg (80mg/kg)   Journal of Drug Research. Vol. 16, Pg. 171, 1985.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
Link to PubMed
mouse LD50 oral 320mg/kg (320mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
mouse LD50 subcutaneous 208mg/kg (208mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rabbit LD50 intravenous 12500ug/kg (12.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
Link to PubMed
rabbit LD50 oral 600mg/kg (600mg/kg)   Drugs in Japan Vol. 6, Pg. 733, 1982.
rat LD50 intraperitoneal 76mg/kg (76mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: IRRITABILITY		 Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 506, 1976.
Link to PubMed
rat LD50 intravenous 21mg/kg (21mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
rat LD50 oral 466mg/kg (466mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1236, 1985.
Link to PubMed
rat LD50 subcutaneous 115mg/kg (115mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12(Suppl,
women LDLo intravenous 40ug/kg (0.04mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA		 Archives of Internal Medicine. Vol. 144, Pg. 173, 1984.
Link to PubMed
women LDLo oral 64mg/kg (64mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: COMA

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE		 Acta Medica Scandinavica. Vol. 210, Pg. 137, 1981.
Link to PubMed
women TDLo oral 8400ug/kg/7D- (8.4mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: TOXIC PSYCHOSIS		 Clinical Toxicology. Vol. 4, Pg. 357, 1971.
Link to PubMed
women TDLo oral 22mg/kg/4W-I (22mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Journal of Clinical Gastroenterology. Vol. 8, Pg. 74, 1986.
women TDLo oral 77mg/kg (77mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Annals of Emergency Medicine. Vol. 14, Pg. 161, 1985.
Link to PubMed
women TDLo oral 160mg/kg (160mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

CARDIAC: OTHER CHANGES		 Annals of Emergency Medicine. Vol. 16, Pg. 1381, 1987.
Link to PubMed

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