Product Name

  • Name

    Protopine

  • EINECS 204-999-6
  • CAS No. 130-86-9
  • Article Data8
  • CAS DataBase
  • Density 1.324 g/cm3
  • Solubility Insoluble in water
  • Melting Point 211oC
  • Formula C20H19NO5
  • Boiling Point 547.479 °C at 760 mmHg
  • Molecular Weight 353.375
  • Flash Point 284.905 °C
  • Transport Information UN 1544
  • Appearance Off-white solid
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 130-86-9 (Protopine)
  • Hazard Symbols
  • Synonyms 7,13a-Secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)- (8CI);Protopine (6CI);Biflorine;Corydinine;Fumarine;Macleyine;Protopin;
  • PSA 57.23000
  • LogP 2.49520

Protopine Chemical Properties

Chemical Name: Protopine
CAS No.: 130-86-9
EINECS: 204-999-6
RTECS Class: Agricultural Chemical and Pesticide
Molecular Formula: C20H19NO5
Molecular Weight: 353.37 g/mol
Density: 1.323 g/cm3 
Flash Point: 284.9 °C
Boiling Point: 547.5 °C at 760 mmHg
Following is the structure of Fumarine (130-86-9):


The chemical synonymous of Fumarine (130-86-9) are 7,13a-Secoberbin-13a-one, 7-Methyl-2,3:9,10-bis(methylenedioxy)- ; 7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-C:5,6-G]azecin-15(7h)-one ; Biflorine ; Bis[1,3]Benzodioxolo[4,5-C:5',6'-G]azecin-13(5H)-one, 4,6,7,14-Tetrahydro-5-methyl- ; Corydinine ; Hypercorine ; Protopin ; Biflorin

Protopine Toxicity Data With Reference

1.    

ipr-rat LDLo:100 mg/kg

     NCNSA6    National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. 5 (1953),24.
2.    

ipr-mus LD50:482 mg/kg

     YHTPAD    Yaoxue Tongbao. Bulletin of Pharmacology. 16 (6)(1981),7.
3.    

orl-gpg LD50:237 mg/kg

     THERAP    Therapie. 28 (1973),767.
4.    

ipr-gpg LD50:116 mg/kg

     THERAP    Therapie. 28 (1973),767.

Protopine Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Attention:
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

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