Product Name

  • Name

    PROXYPHYLLINE

  • EINECS 210-028-7
  • CAS No. 603-00-9
  • Article Data12
  • CAS DataBase
  • Density 1.46 g/cm3
  • Solubility 285.7g/L(temperature not stated)
  • Melting Point 134-136°C
  • Formula C10H14 N4 O3
  • Boiling Point 487.2ºC
  • Molecular Weight 238.246
  • Flash Point 248.5ºC
  • Transport Information
  • Appearance
  • Safety Moderately toxic by ingestion, intraperitoneal, subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See also THEOPHYLLINE.
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 603-00-9 (PROXYPHYLLINE)
  • Hazard Symbols Xn
  • Synonyms Theophylline,7-(2-hydroxypropyl)- (6CI,7CI,8CI); (?à)-Proxyphyllin; 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine;2,6-Dioxo-3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethylpurine;2-Hydroxypropyl-7-theophylline; 7-(2-Hydroxypropyl)theophylline; 7-(b-Hydroxypropyl)-1,3-dimethylxanthine;7-(b-Hydroxypropyl)theophylline;Brontyl; Hydroxypropyltheophylline; Monophylline; NSC 163343;Oxypropyltheophylline; Proxiphylline; Proxy-Retardoral; Proxyphylline;Purophyllin; Sanwaphyllin; Sigophyl; Spantin; Spasmolysin; Thean; Theoden;Theon; b-Hydroxypropyltheophylline
  • PSA 82.05000
  • LogP -1.18550

Proxyphylline Chemical Properties

Chemical Name: Proxyphylline
IUPAC NAME: 7-(2-Hydroxypropyl)-1,3-dimethylpurine-2,6-dione
CAS No.: 603-00-9
EINECS: 210-028-7
RTECS: XH5907500
Molecular Formula: C10H14N4O3
Molecular Weight: 238.24 g/mol
Melting Point: 134-136°C
Density: 1.46 g/cm3 
Flash Point: 248.5 °C
Boiling Point: 487.2 °C at 760 mmHg
Following is the structure of β-Hydroxypropyltheophylline (603-00-9):


The chemical synonymous of β-Hydroxypropyltheophylline (603-00-9) are 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine ; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)- ; 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl- ; 2-Hydroxypropyl-7-theophylline ; 3,7-Dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-1h-purine-6-dione ; 3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione ; 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1h-purine-6-dione ; 7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione 

Proxyphylline Toxicity Data With Reference

1.    

orl-rat LD50:460 mg/kg

     OYYAA2    Oyo Yakuri. Pharmacometrics. 19 (1980),845.
2.    

ipr-rat LD50:445 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),720.
3.    

ivn-rat LD50:430 mg/kg

     OYYAA2    Oyo Yakuri. Pharmacometrics. 19 (1980),845.
4.    

orl-mus LD50:730 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),720.
5.    

ipr-mus LD50:505 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 27 (1977),14.
6.    

scu-mus LD50:410 mg/kg

     ARZNAD    Arzneimittel-Forschung. Drug Research. 4 (1954),649.
7.    

ivn-mus LD50:475 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),720.

Proxyphylline Safety Profile

Moderately toxic by ingestion, intraperitoneal, subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See also THEOPHYLLINE.
Hazard Codes:
Xn: Harmful
Risk Statements about β-Hydroxypropyltheophylline (603-00-9):
R22 Harmful if swallowed.
Safety Statements about β-Hydroxypropyltheophylline (603-00-9):
S36 Wear suitable protective clothing.

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