Toxicity data
(The meaning of any toxicological abb
IUPAC Name: 2-Amino-N-[(2S,3R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
The molecular formula of Puromycin dihydrochloride (CAS NO.58-58-2) is C22H31Cl2N7O5.
The molecular weight of Puromycin dihydrochloride (CAS NO.58-58-2) is 544.43.
Synonyms of Puromycin dihydrochloride (CAS NO.58-58-2): L-3'-(A-Amino-P-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine dihydrochloride ; Stylomycin dihydrochloride
Stability: Stable. Heat sensitive. Incompatible with strong oxidizing agents
Product Categories: Antibiotics
Appearance: white powder
Storage temp: -20 °C
Flash Point: 460.6 °C
Boiling Point: 838 °C
EINECS: 200-387-8
Puromycin dihydrochloride (CAS NO.58-58-2) is used as chemical reagent, organic intermediates, fine chemicals, pharmaceutical research and development.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intramuscular | 202mg/kg (202mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
guinea pig | LD50 | intramuscular | 202mg/kg (202mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
guinea pig | LD50 | intraperitoneal | 287mg/kg (287mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
guinea pig | LD50 | intraperitoneal | 287mg/kg (287mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
guinea pig | LD50 | oral | 600mg/kg (600mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
guinea pig | LD50 | oral | 600mg/kg (600mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
mouse | LD50 | intraperitoneal | 580mg/kg (580mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
mouse | LD50 | intraperitoneal | 580mg/kg (580mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
mouse | LD50 | intravenous | 335mg/kg (335mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
mouse | LD50 | intravenous | 335mg/kg (335mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
mouse | LD50 | oral | 720mg/kg (720mg/kg) | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. | |
mouse | LD50 | oral | 720mg/kg (720mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Antibiotics Annual. Vol. 2, Pg. 757, 1954/1955. |
Mutation data reported. When heated to decomposition it emits toxic fumes of NOx and HCl.Safety information of Puromycin dihydrochloride (CAS NO.58-58-2):
Hazard Codes Xn
Risk Statements
22 Harmful if swallowed
40 Limited evidence of a carcinogenic effect
RIDADR 3249
WGK Germany 3
RTECS AU7355000
F 3-8-10
HazardClass 6.1(b)
PackingGroup III
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