Product Name

  • Name

    PYRIDOSTIGMINE

  • EINECS
  • CAS No. 155-97-5
  • Density g/cm3
  • Solubility
  • Melting Point
  • Formula C9H13 N2 O2
  • Boiling Point °Cat760mmHg
  • Molecular Weight 181.24
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, intramuscular, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. See also CARBAMATES and ESTERS.
  • Risk Codes
  • Molecular Structure Molecular Structure of 155-97-5 (PYRIDOSTIGMINE)
  • Hazard Symbols
  • Synonyms Pyridinium,3-hydroxy-1-methyl-, dimethylcarbamate (6CI); Pyridinium, 3-hydroxy-1-methyl-,dimethylcarbamate (ester) (8CI); Pyridostigmine
  • PSA 33.42000
  • LogP 0.57150

Pyridostigmine Chemical Properties

IUPAC Name: 1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate
Synonyms of Pyridostigmine (CAS NO.155-97-5): 3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium ; Pyridostigminum ; Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl- (9CI) ; Pyridinium, 3-hydroxy-1-methyl-, dimethylcarbamate (ester)
CAS NO: 155-97-5
Molecular Formula: C9H13N2O2
Molecular Weight :181.2112
Molecular Structure:  
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 2
Polar Surface Area: 33.42 Å2

Pyridostigmine Uses

 Pyridostigmine (CAS NO.155-97-5) is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity.

Pyridostigmine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1867ug/kg (1.867mg/kg)   Journal of Medicinal Chemistry. Vol. 33, Pg. 577, 1990.
mouse LD50 intraperitoneal 2700ug/kg (2.7mg/kg)   Fundamental and Applied Toxicology. Vol. 1, Pg. 217, 1981.
mouse LD50 subcutaneous 3300ug/kg (3.3mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 45, Pg. 9, 1979.
rabbit LD50 intramuscular 2800ug/kg (2.8mg/kg)   Drug and Chemical Toxicology. Vol. 3, Pg. 319, 1980.
rabbit LD50 oral 53900ug/kg (53.9mg/kg)   Drug and Chemical Toxicology. Vol. 3, Pg. 319, 1980.
rat LD50 intramuscular 2790ug/kg (2.79mg/kg)   Drug and Chemical Toxicology. Vol. 1, Pg. 355, 1978.

Pyridostigmine Safety Profile

Poison by ingestion, intramuscular, and intraperitoneal routes. When Pyridostigmine (CAS NO.155-97-5) is heated to decomposition, it emits toxic fumes of NOx. See also CARBAMATES and ESTERS.

Pyridostigmine Specification

 Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood-brain barrier, except possibly in stressful conditions.

Contraindications: Pyrostigmine bromide is contraindicated in cases of mechanical intestinal or urinary obstruction and should be used with caution in patients with bronchial asthma .

Side effects: Common side effects include: Nausea ;Vomiting ;Diarrhea ;Abdominal cramps ;Increased salivation ;Tearing ;Increased bronchial secretions ;Constricted pupils.

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