Product Name

  • Name

    QUAZEPAM CIV (200 MG)

  • EINECS 253-179-4
  • CAS No. 36735-22-5
  • Density 1.42 g/cm3
  • Solubility
  • Melting Point 22°C
  • Formula C17H11 Cl F4 N2 S
  • Boiling Point 429.9 °C at 760 mmHg
  • Molecular Weight 386.8
  • Flash Point 213.8 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 36735-22-5 (QUAZEPAM CIV (200 MG))
  • Hazard Symbols
  • Synonyms 7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione;7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione;Doral; Dormalin; NSC 309702; Oniria; Prosedar; Quazepam; Quazium; Sch 16134;Selepam
  • PSA 47.69000
  • LogP 4.52680

Synthetic route

quazepam
36735-22-5

quazepam

[3H]-2-Oxoquazepam
49606-44-2

[3H]-2-Oxoquazepam

Conditions
ConditionsYield
With Hg(CH3COO)2 at 20℃; for 0.25h; pH 11.2 (Britton-Robinson buffer); 40percent DMF as solubilisator;100%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 10℃;50%
mercaptoacetic acid
68-11-1

mercaptoacetic acid

quazepam
36735-22-5

quazepam

10-chloro-7,11b-dihydro-11b-(2-fluorophenyl)-7-(2,2,2-trifluoro-ethyl)-thiazolo<3,2-d><1,4>benzodiazepin-3(2H)one-6(5H)thione

10-chloro-7,11b-dihydro-11b-(2-fluorophenyl)-7-(2,2,2-trifluoro-ethyl)-thiazolo<3,2-d><1,4>benzodiazepin-3(2H)one-6(5H)thione

Conditions
ConditionsYield
In benzene for 45h; Heating;42%

Quazepam Chemical Properties

IUPAC Name: 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
The MF of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is C9H6N2S.

                                           
The MW of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is 174.22234.
Synonyms of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5): 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- ; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(2,2, 2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
Apperance: dichloromethane - hexane crystallization
Index of Refraction: 1.595 
EINECS: 253-179-4
Density: 1.42 g/ml 
Flash Point: 213.8 °C
Boiling Point: 429.9 °C
Melting Point: 137.5-139 °C

Quazepam Uses

   2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is benzodiazepine class with a typical anti-anxiety, anti-seizure and muscle relaxant effect and low toxicity. Used for a variety of insomnia.

Quazepam Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD oral > 1gm/kg (1000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ANALGESIA		 Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982.
dog LD oral > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
mouse LD50 intraperitoneal 845mg/kg (845mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
mouse LDLo oral 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982.
rat LD50 intraperitoneal 2749mg/kg (2749mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.
rat LD50 oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987.

Quazepam Safety Profile

Safety information of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5):
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III

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