Product Name

  • Name

    4,4'-propylenebis(piperazine-2,6-dione)

  • EINECS 244-379-2
  • CAS No. 21416-67-1
  • Article Data1
  • CAS DataBase
  • Density 1.333g/cm3
  • Solubility 3g/L(25 oC)
  • Melting Point 193oC
  • Formula C11H16 N4 O4
  • Boiling Point 531.5°Cat760mmHg
  • Molecular Weight 268.272
  • Flash Point 275.3°C
  • Transport Information
  • Appearance
  • Safety Suspected human carcinogen producing leukemia and skin tumors. Moderately toxic by intraperitoneal route. Human effects: normocytic anemia and thrombocytopenia. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 21416-67-1 (4,4'-propylenebis(piperazine-2,6-dione))
  • Hazard Symbols
  • Synonyms 2,6-Piperazinedione,4,4'-propylenedi- (8CI);4,4'-Propylenebis(2,6-piperazinedione);4,4'-Propylenedi(2,6-piperazinedione);ICI 59118;ICRF 159;NSC 129943;Razoxane;Razoxin;Tepirone;Troxozone;83713-23-9;
  • PSA 98.82000
  • LogP -2.17490

Razoxane Chemical Properties

 Razoxane with cas register number of 21416-67-1 is also named as Razoxanum ; Troxozone ; CCRIS 344 ; ICRF 159 ; ICRF-161 ; CHEBI:50231 ; CID88893 ; 4,4'-Propylenebis(piperazine-2,6-dione) ; Razoxanum ; 4,4'-(1-Methylethylene)bis(2,6-piperazinedione) ,and so on.
IUPAC Name: 4-[3-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
CAS: 21416-67-1
Molecular Formula: C11H16N4O4
Molecular Weight: 268.26914
Molecular structure:
EINECS: 244-379-2
ACD/LogD (pH 5.5):  -0.38 
ACD/LogD (pH 7.4):  -0.37 
ACD/BCF (pH 5.5):  1 
ACD/BCF (pH 7.4):  1 
ACD/KOC (pH 5.5):  14.87 
ACD/KOC (pH 7.4):  14.91 
H bond acceptors:  8 
H bond donors:  2 
Freely Rotating Bonds:  3 
Index of Refraction:  1.539 
Molar Refractivity:  63.12 cm3 
Molar Volume:  201.2 cm3 
Polarizability:  25.02×10-24cm3 
Surface Tension:  51.6 dyne/cm 
Density:  1.333 g/cm3 
Flash Point:  275.3 °C 
Enthalpy of Vaporization:  80.71 kJ/mol 
Boiling Point:  531.5 °C at 760 mmHg 
Vapour Pressure:  2.22E-11 mmHg at 25°C 

Razoxane Uses

 Razoxane (CAS No.21416-67-1) may be used as pharmaceutical material.

Razoxane Toxicity Data With Reference

1.    

dni-hmn:lym 20 mg/L

     INNDDK    Investigational New Drugs. The Journal of New Anticancer Agents. 1 (1983),283.
2.    

oms-hmn:lym 20 mg/L

     INNDDK    Investigational New Drugs. The Journal of New Anticancer Agents. 1 (1983),283.
3.    

mnt-mus-ipr 200 mg/kg

     BJCAAI    British Journal of Cancer. 52 (1985),725.
4.    

cyt-ham-orl 100 mg/kg

     BJCAAI    British Journal of Cancer. 52 (1985),725.
5.    

orl-man TDLo:693 mg/kg/77W-I:CAR

     LANCAO    Lancet. 2 (1981),1343.
6.    

orl-wmn TD:4650 mg/kg/2Y-C:CAR

     LANCAO    Lancet. 2 (1981),1343.
7.    

orl-wmn TDLo:3650 mg/kg/2Y-I:BLD

     LANCAO    Lancet. 2 (1987),1085.
8.    

unr-wmn TDLo:600 mg/kg/34W-I:BLD

     BJDEAZ    British Journal of Dermatology. 113 (1985),131.
9.    

unr-man TDLo:6467 mg/kg/6Y-I:BLD

     BJDEAZ    British Journal of Dermatology. 113 (1985),131.
10.    

ipr-mus LD50:500 mg/kg

     CPBTAL    Chemical and Pharmaceutical Bulletin. 29 (1981),1594.

Razoxane Safety Profile

Suspected human carcinogen producing leukemia and skin tumors. Razoxane (CAS No.21416-67-1) is moderately toxic by intraperitoneal route. Human effects: normocytic anemia and thrombocytopenia. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

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