Product Name

  • Name

    pamaquine

  • EINECS
  • CAS No. 491-92-9
  • Density 1.0600 (rough estimate)
  • Solubility
  • Melting Point 25°C
  • Formula C19H29N3O
  • Boiling Point bp0.3 175-180°; bp1 182-194°
  • Molecular Weight 315.459
  • Flash Point
  • Transport Information
  • Appearance
  • Safety Human poison by an unspecified route. Experimental poison by ingestion, subcutaneous, intravenous, and intramuscular routes. When heated to decomposition it emits toxic fumes of NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 491-92-9 (pamaquine)
  • Hazard Symbols
  • Synonyms PAMAQUINE;Plasmochin;Aminoquin;Prequine;Plasmoquine;Rhodoquine;Beprochine;Pamaquin;Praequine;Plasmocide;
  • PSA 37.39000
  • LogP 4.23880

Rhodoquine Chemical Properties

Product Name: 1-N,1-N-Diethyl-4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine 
Synonyms of Rhodoquine (CAS NO.491-92-9) : 1,4-Pentanediamine, N~1~,N~1~-diethyl-N~4~-(6-methoxy-8-quinolinyl)- ; 8-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methoxyquinoline ; N~1~,N~1~-Diethyl-N~4~-(6-methoxy-8-quinolinyl)-1,4-pentanediamine ; N1,N1-Diethyl-N5-(6-methoxy-8-quinolinyl)-1,4-pentanediamine ; Quinoline, 8-[[4- (diethylamino)-1-methylbutyl]amino]-6-methoxy-
CAS NO: 491-92-9  
Molecular Formula:C19H29N3O                                 
Molecular Weight :315.4531                                             
Molecular Structure :
Index of Refraction:1.575        
Surface Tension: 41.7 dyne/cm 
Density: 1.051 g/cm3 
Flash Point: 238.2 °C 
Enthalpy of Vaporization: 73.28 kJ/mol 
Boiling Point: 470.3 °C at 760 mmHg 
Vapour Pressure: 5.13E-09 mmHg at 25°C 

Rhodoquine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LDLo intramuscular 33mg/kg (33mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
bird - domestic LDLo oral 66mg/kg (66mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
cat LDLo intravenous 5mg/kg (5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
cat LDLo oral 7500ug/kg (7.5mg/kg) BEHAVIORAL: COMA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
cat LDLo subcutaneous 5mg/kg (5mg/kg) BEHAVIORAL: COMA

BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
chicken LDLo oral 57mg/kg (57mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 201, Pg. 402, 1943.
dog LDLo subcutaneous 20mg/kg (20mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
man LDLo unreported 7353ug/kg (7.353mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 oral 68mg/kg (68mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 6, Pg. 185, 1951.
mouse LDLo subcutaneous 12500ug/kg (12.5mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
rabbit LDLo intravenous 3500ug/kg (3.5mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.
rabbit LDLo oral 220mg/kg (220mg/kg)   Rivista di Malariologia. Vol. 11, Pg. 3, 1932.
rabbit LDLo subcutaneous 20mg/kg (20mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 144, Pg. 341, 1929.

Rhodoquine Safety Profile

Human poison by an unspecified route. Experimental poison by ingestion, subcutaneous, intravenous, and intramuscular routes. When Rhodoquine (CAS NO.491-92-9) is heated to decomposition, it emits toxic fumes of NOx.

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