Product Name

  • Name

    Tiazofurine

  • EINECS
  • CAS No. 60084-10-8
  • Article Data12
  • CAS DataBase
  • Density 1.648g/cm3
  • Solubility
  • Melting Point 145-146°
  • Formula C9H12 N2 O5 S
  • Boiling Point 641.3°C at 760 mmHg
  • Molecular Weight 260.271
  • Flash Point 341.6°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by intravenous and intraperitoneal routes. Human systemic effects by intravenous route: headache, convulsions, and musculo-skeletal changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Risk Codes
  • Molecular Structure Molecular Structure of 60084-10-8 (Tiazofurine)
  • Hazard Symbols
  • Synonyms 2-b-D-Ribofuranosylthiazole-4-carboxamide;CI 909; NSC 286-193; NSC 286193; Riboxamide; TCAR; Tiazofurin; Tiazofurine
  • PSA 154.14000
  • LogP -0.90370

Riboxamide Chemical Properties

IUPAC Name: 2-[3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]thiazole-4-carboxamide
Synonyms: 1,4-Anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)pentitol ; 2-((2R,4R,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-thiazole-4-carboxylic acid amide ; 2-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-thiazole-4-carboxylic acid amide ; 2-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-thiazole-4-carboxylic acid amide(tiazofurin) ; 2-[3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
CAS NO: 60084-10-8
Molecular Formula of Riboxamide (CAS NO.60084-10-8) : C9H12N2O5S
Molecular Weight of Riboxamide (CAS NO.60084-10-8)  : 260.267
Molecular Structure of Riboxamide (CAS NO.60084-10-8) :
Index of Refraction: 1.674
Surface Tension: 88.5 dyne/cm
Density: 1.648 g/cm3
Flash Point: 341.6 °C
Enthalpy of Vaporization: 99.49 kJ/mol
Boiling Point: 641.3 °C at 760 mmHg
Vapour Pressure: 2.53E-17 mmHg at 25°C

Riboxamide Toxicity Data With Reference

1.    

dni-mus:lym 10 µmol/L

     CNREA8    Cancer Research. 45 (1985),5512.
2.    

dni-mus:leu 10 µmol/L

     BCPCA6    Biochemical Pharmacology. 34 (1985),1109.
3.    

ivn-hmn TDLo:1135 mg/kg/15D-I:CNS,MSK

     CNREA8    Cancer Research. 45 (1985),5169.
4.    

ivn-hmn TDLo:892 mg/kg/10D-I:CNS

     CNREA8    Cancer Research. 45 (1985),5169.
5.    

ipr-mus LD50:1684 mg/kg

     NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
6.    

ivn-mus LD50:3400 mg/kg

     NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB83-156901 .
7.    

ivn-dog LDLo:1090 mg/kg

     NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB83-156901 .

Riboxamide Safety Profile

Moderately toxic by intravenous and intraperitoneal routes. Human systemic effects by intravenous route: headache, convulsions, and musculo-skeletal changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

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