Product Name

  • Name

    rifamide

  • EINECS
  • CAS No. 2750-76-7
  • Density 1.3g/cm3
  • Solubility
  • Melting Point 170°C (rough estimate)
  • Formula C43H58 N2 O13
  • Boiling Point 927.4°Cat760mmHg
  • Molecular Weight 810.939
  • Flash Point 514.7°C
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Used as an antibacterial agent.
  • Risk Codes
  • Molecular Structure Molecular Structure of 2750-76-7 (rifamide)
  • Hazard Symbols
  • Synonyms Acetamide,2-[(1,2-dihydro-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-9-yl)oxy]-N,N-diethyl-,21-acetate (7CI,8CI);2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.; M14; M 14 (antibiotic); N,N-Diethylrifamycin B amide; NCI 143-418; NSC 133099;NSC 143418; Ribomycin B amide, N,N-diethyl-; Rifamide; Rifampicin M 14;Rifamycin B diethylamide; Rifamycin B, N,N-diethylamide; Rifamycin M14;Rifomide; Rifomycin B diethylamide; Rifomycin M14
  • PSA 210.62000
  • LogP 5.43370

Rifamide Chemical Properties

Product Name: Rifamide 
Synonyms of Rifamide (CAS NO.2750-76-7) : (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-27-[2-(Diethylamino)-2-oxoethoxy]-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo [23.3.1.1~4,7~.0~5,28~]triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate ; 2-[(1,2-Dihydro-5,6,17,19,21-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-9-yl)oxy]-N,N-diethylacetamide 21-Acetate ; 4-O-[2-(Diethylamino)-2-oxoethyl]rifamycin ; Acetamide, 2-[[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(acetyloxy)-1,2-dihydro-5,6,17,19-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-2,7-(epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-9-yl]oxy]-N,N-diethyl- ; N,N-Diethylrifomycin B Amide
CAS NO: 2750-76-7
Molecular Formula:C43H58N2O13                                
Molecular Weight :810.9262                                           
Molecular Structure :
EINECS: 220-390-8
Index of Refraction: 1.608       
Surface Tension: 62.1 dyne/cm 
Density: 1.3 g/cm3 
Flash Point: 544.6 °C 
Enthalpy of Vaporization: 149.12 kJ/mol 
Boiling Point: 976.8 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C 

Rifamide Uses

 Rifamide (CAS NO.2750-76-7) is used as an antibacterial agent.

Rifamide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 425mg/kg (425mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
mouse LD50 intraperitoneal 320mg/kg (320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
mouse LD50 intravenous 315mg/kg (315mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
mouse LD50 oral 2450mg/kg (2450mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
mouse LD50 subcutaneous 640mg/kg (640mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
rabbit LD50 intravenous 550mg/kg (550mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
rabbit LD50 subcutaneous 2500mg/kg (2500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
rat LD50 intraperitoneal 535mg/kg (535mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
rat LD50 intravenous 380mg/kg (380mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS		 Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966
rat LD50 oral > 4gm/kg (4000mg/kg)   Toxicology and Applied Pharmacology. Vol. 8, Pg. 126, 1966.
rat LD50 subcutaneous 2500mg/kg (2500mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Rifamide Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When Rifamide (CAS NO.2750-76-7) is heated to decomposition, it emits toxic fumes of NOx.

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