• Name

  Rifamycin sodium salt

• EINECS 238-965-7
• CAS No. 14897-39-3
• Density 1.35 g/cm³
• Solubility Soluble in water, alcohol and dimethyl sulfoxide.
• Melting Point >215°C (dec.)
• Formula C₃₇H₄₆NNaO₁₂
• Boiling Point 862.1oC at 760mmHg
• Molecular Weight 719.762
• Flash Point 475.2oC
• Transport Information
• Appearance COA
• Safety 22-24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Rifamycin, monosodium salt (9CI);CB 01-11;Monosodium rifamycin SV;NSC 146718;Rifamycin SV sodium;Tuborin;Rifamycin, sodium salt(1:1);
• PSA 204.14000
• LogP 5.18780

Synthetic route

14897-39-3

monosodium rifamycin SV

4,11-dideoxy-4,11-dihydroxyiminorifamycin S

Conditions

Conditions	Yield
With pyridine; hydroxylamine hydrochloride In methanol at 20℃;	83%

14897-39-3

monosodium rifamycin SV

55686-22-1

N,N-dihydroxymethyltert-butylamine

N-tert-1,3-oxazine(5,6-c)rifamycin

Conditions

Conditions	Yield
Stage #1: monosodium rifamycin SV With sulfuric acid In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N,N-dihydroxymethyltert-butylamine In N,N-dimethyl-formamide at 45℃; for 2h; Time; Concentration;
Stage #1: monosodium rifamycin SV With sulfuric acid In N,N-dimethyl-formamide at 20℃; for 0.75h; Stage #2: N,N-dihydroxymethyltert-butylamine In N,N-dimethyl-formamide at 45℃; for 2h; Temperature; Concentration;
Stage #1: monosodium rifamycin SV With sulfuric acid In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: N,N-dihydroxymethyltert-butylamine In N,N-dimethyl-formamide at 35 - 50℃; for 2h;	1.03 g

14897-39-3

monosodium rifamycin SV

62623-68-1, 76188-88-0, 81203-58-9, 101978-28-3, 13553-79-2

rifamycin S

Conditions

Conditions	Yield
With p-benzoquinone In Isopropyl acetate at 20℃; for 0.0833333h; Reagent/catalyst;

14897-39-3

monosodium rifamycin SV

fluorobenzoxazino rifamycin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: p-benzoquinone / Isopropyl acetate / 0.08 h / 20 °C 2.1: Isopropyl acetate / 25 °C 2.2: -5 - 25 °C / Flow reactor 2.3: 25 °C / Flow reactor View Scheme

14897-39-3

monosodium rifamycin SV

845625-44-7

dimethylpiperidyl benzoxazino rifamycin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: p-benzoquinone / Isopropyl acetate / 0.08 h / 20 °C 2.1: Isopropyl acetate / 25 °C 2.2: -5 - 25 °C / Flow reactor 2.3: 25 °C / Flow reactor 3.1: tetrahydrofuran / 2 h / 0 - 25 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: p-benzoquinone / Isopropyl acetate / 0.08 h / 20 °C 2: manganese(IV) oxide / toluene / 20 °C 3: manganese(IV) oxide / dimethyl sulfoxide / 20 °C View Scheme

14897-39-3

monosodium rifamycin SV

143526-61-8

3'-tert-butyldimethylsilyloxybenzoxazinorifamycin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: p-benzoquinone / Isopropyl acetate / 0.08 h / 20 °C 2: manganese(IV) oxide / toluene / 20 °C View Scheme

Rifamycin sodium salt Chemical Properties

Rifamycin sodium salt Uses

Rifamycin sodium salt Safety Profile